New insights into structural determinants of prion protein folding and stability

Prions are the etiological agent of fatal neurodegenerative diseases called prion diseases or transmissible spongiform encephalopathies. These maladies can be sporadic, genetic or infectious disorders. Prions are due to post-translational modifications of the cellular prion protein leading to the formation of a \u3b2-sheet enriched conformer with altered biochemical properties. The molecular events causing prion formation in sporadic prion diseases are still elusive. Recently, we published a research elucidating the contribution of major structural determinants and environmental factors in prion protein folding and stability. Our study highlighted the crucial role of octarepeats in stabilizing prion protein; the presence of a highly enthalpically stable intermediate state in prion-susceptible species; and the role of disulfide bridge in preserving native fold thus avoiding the misfolding to a \u3b2-sheet enriched isoform. Taking advantage from these findings, in this work we present new insights into structural determinants of prion protein folding and stability

Simultaneous XMM-Newton and ESO VLT observations of SN 1995N: probing the wind/ejecta interaction

We present the results of the first {\it XMM-Newton} observation of the interacting type IIn supernova 1995N, performed in July 2003. We find that the 0.2--10.0 keV unabsorbed flux dropped at a value of $\simeq 1.8 \times 10^{-13}$ erg cm$^{-2}$ s$^{-1}$, almost one order of magnitude lower than that of a previous {\it ASCA} observation of January 1998. From all the available X-ray measurements, an interesting scenario emerges where the X-ray light emission may be produced by a two-phase (clumpy/smooth) circumstellar medium. The X-ray spectral analysis shows statistically significant evidence for the presence of two distinct components, that can be modeled with emission from optically thin, thermal plasmas at different temperatures. The exponent of the ejecta density distribution inferred from these temperatures is $n\simeq 6.4$. From the fluxes of the two spectral components we derive an estimate of the mass loss rate of the supernova progenitor, ${\dot M} \sim 2 \times 10^{-4} M_\odot {\rm yr}^{-1}$, at the upper end of the interval exhibited by red super-giants. Coordinated optical and infrared observations allow us to reconstruct the simultaneous infrared to X-ray flux distribution of SN 1995N. We find that, at $\sim$ 9 years after explosion, the direct X-ray thermal emission due to the wind/ejecta interaction is $\sim 5$ times larger than the total reprocessed IR/optical flux.Comment: 11 pages, 7 figures, MNRAS, in pres

Long Gamma-Ray Bursts and Type Ic Core Collapse Supernovae Have Similar Locations in Hosts

When the afterglow fades at the site of a long-duration gamma-ray burst (LGRB), Type Ic supernovae (SN Ic) are the only type of core collapse supernova observed. Recent work found that a sample of LGRB in high-redshift galaxies had different environments from a collection of core-collapse environments, which were identified from their colors and light curves. LGRB were in the brightest regions of their hosts, but the core-collapse sample followed the overall distribution of the galaxy light. Here we examine 504 supernovae with types assigned based on their spectra that are located in nearby (z < 0.06) galaxies for which we have constructed surface photometry from the Sloan Digital Sky Survey (SDSS). The distributions of the thermonuclear supernovae (SN Ia) and some varieties of core-collapse supernovae (SN II and SN Ib) follow the galaxy light, but the SN Ic (like LGRB) are much more likely to erupt in the brightest regions of their hosts. The high-redshift hosts of LGRB are overwhelmingly irregulars, without bulges, while many low redshift SN Ic hosts are spirals with small bulges. When we remove the bulge light from our low-redshift sample, the SN Ic and LGRB distributions agree extremely well. If both LGRB and SN Ic stem from very massive stars, then it seems plausible that the conditions necessary for forming SN Ic are also required for LGRB. Additional factors, including metallicity, may determine whether the stellar evolution of a massive star leads to a LGRB with an underlying broad-lined SN Ic, or simply a SN Ic without a gamma-ray burst.Comment: Accepted by the Astrophysical Journal, 12 pages, 3 tables, 4 figures, SN sample size increases from 263 to 504 in v2, varying host magnitude and distance shown not to introduce systematic error in measurement

Explosion of a massive, He-rich star at z=0.16

We present spectroscopic and photometric data of the peculiar SN 2001gh, discovered by the 'Southern inTermediate Redshift ESO Supernova Search' (STRESS) at a redshift z=0.16. SN 2001gh has relatively high luminosity at maximum (M_B = -18.55 mag), while the light curve shows a broad peak. An early-time spectrum shows an almost featureless, blue continuum with a few weak and shallow P-Cygni lines that we attribute to HeI. HeI lines remain the only spectral features visible in a subsequent spectrum, obtained one month later. A remarkable property of SN 2001gh is the lack of significant spectral evolution over the temporal window of nearly one month separating the two spectra. In order to explain the properties of SN 2001gh, three powering mechanism are explored, including radioactive decays of a moderately large amount of 56Ni, magnetar spin-down, and interaction of SN ejecta with circumstellar medium. We favour the latter scenario, with a SN Ib wrapped in a dense, circumstellar shell. The fact that no models provide an excellent fit with observations, confirms the troublesome interpretation of the nature of SN 2001gh. A rate estimate for SN 2001gh-like event is also provided, confirming the intrinsic rarity of these objects.Comment: 11 pages, 8 figures, 3 tables. Accepted by MNRA

Moderately Luminous type II Supernovae

Core-collapse Supernovae (CC-SNe) descend from progenitors more massive than about 8 Msun. Because of the young age of the progenitors, the ejecta may eventually interact with the circumstellar medium (CSM) via highly energetic processes detectable in the radio, X-ray, ultraviolet (UV) and, sometimes, in the optical domains. In this paper we present ultraviolet, optical and near infrared observations of five type II SNe, namely SNe 2009dd, 2007pk, 2010aj, 1995ad, and 1996W. Together with few other SNe they form a group of moderately luminous type II events. We collected photometry and spectroscopy with several telescopes in order to construct well-sampled light curves and spectral evolutions from the photospheric to the nebular phases. Both photometry and spectroscopy indicate a degree of heterogeneity in this sample. The light curves have luminous peak magnitudes ($-16.95<M_{B}<-18.70$). The ejected masses of ^56\ni for three SNe span a wide range of values ($2.8\times10^{-2}$Msun$<$M(\ni)$<1.4\times10^{-1}$Msun), while for a fourth (SN2010aj) we could determine a stringent upper limit ($7\times10^{-3}$Msun). Clues of interaction, such as the presence of high velocity (HV) features of the Balmer lines, are visible in the photospheric spectra of SNe 2009dd and 1996W. For SN2007pk we observe a spectral transition from a type IIn to a standard type II SN. Modelling the observations of SNe 2009dd, 2010aj and 1995ad with radiation hydrodynamics codes, we infer kinetic plus thermal energies of about 0.2-0.5 foe, initial radii of 2-5$\times10^{13}$ cm and ejected masses of $\sim$5.0-9.5 Msun. These values suggest moderate-mass, super-asymptotic giant branch (SAGB) or red super-giants (RSG) stars as SN precursors, in analogy with other luminous type IIP SNe 2007od and 2009bw.Comment: 28 pages, 27 fig, accepted by A&A, 3 pages of online material, abstract abridged. revised significantly with respect to the previous versio