Management of Oral Cavity Mucormycosis in a Ketoacidotic Patient with Targeted Debridement and a Palate Obturator

Mucormycosis is an opportunistic mycosis common in poorly-controlled insulin dependent diabetic patients particularly with ketoacidosis. It often begins as a nasal and paranasal sinus infection with inhalation of spores into the paranasal sinuses of a susceptible host. In this case report we review the clinical symptoms, relevant imaging, and management of a diabetic patient with mucormycosis threatening his better seeing eye. This case report offers the clinician a review of important clinical and diagnostic findings that can help direct the need for orbital exenteration. In addition, various reconstruction options are considered to help guide informed management

Extent of craniofacial fungal osteomyelitis in a ketoacidotic patient may predict optic nerve involvement: A case report

Introduction: Mucormycosis is an opportunistic mycosis common in poorly-controlled insulin dependent diabetic patients particularly with ketoacidosis. Fungal osteomyelitis is a life-threatening condition affectation of the nose and paranasal sinuses within the orofacial region. Presentation of case: We present a 63-year-old diabetic male patient with maxillary mucormycotic osteomyelitis threatening his better seeing eye and review the clinical symptoms, relevant imaging, and management. Discussion: We highlight a rare pattern of craniofacial fungal bone infection with maxillary and orbital involvement that ultimately spared the optic nerve. This case report offers the clinician a review of important clinical and diagnostic findings that can help direct the need for orbital exenteration. Conclusion: Maxillary mucormycotic osteomyelitis is an aggressive infection that needs to be addressed promptly to prevent fatal consequences

Microbicides as an HIV Prevention Tool: A Review of the Literature

Biomedical HIV prevention research findings are becoming increasingly prevalent in the literature, but in order to get an accurate picture of prevention possibility, adherence and environment must be carefully considered. This essay reviews the available literature, examining reported microbicide trials and participant adherence. Many microbicide trials fail to show efficacy, but participants’ adherence is not examined in detail. Even though there have been successes in trials testing microbicides as HIV prevention, the general trend is to dismiss them and explore other opportunities for prevention. Because behavioral interventions have not been entirely effective, microbicide research is significant to public health because it adds a biomedical dimension to the existing prevention effort. This essay aims to show that further studies of both microbicidal efficacy and means to increase participant adherence are needed to move the field of HIV prevention forward

LatCrit at Twenty-Five and beyond - Organized Academic Activism and the Long Haul: Designing Hybridized Advocacy Projects for an Age of Global Disruption, Systemic Injustice, and Bottom-up Progress

On the monumental occasion of the twenty-fifth anniversary celebration of LatCrit (Latina and Latino Critical Legal Theory, Inc.) as a still thriving and persevering community of critical scholars and activists, this Article offers some reflections on where we have been, where we are now, and where we might go next together as academics and organizers of long-term collective action. Against the current disruptions of a global pandemic, aggravated by planetary climate collapse, disinformation campaigns, and the organized top-down sabotage of U.S. democracy itself, our community responses going forward must be both more democratic and decentralized than ever, as well as more coordinated and coalitional, utilizing the innovations of critical hybridized praxis and of systemic advocacy projects of social and academic activism. If we act in the ways and values this Afterword outlines, now and for the long haul, we can achieve tactical, operational, and structural gains long imagined and sought by our community and allies

The Specific Globular Cluster Frequencies of Dwarf Elliptical Galaxies from the Hubble Space Telescope

The specific globular cluster frequencies (S_N) for 24 dwarf elliptical (dE) galaxies in the Virgo and Fornax Clusters and the Leo Group imaged with the Hubble Space Telescope are presented. Combining all available data, we find that for nucleated dEs --- which are spatially distributed like giant ellipticals in galaxy clusters --- S_N(dE,N)=6.5 +- 1.2 and S_N increases with M_V, while for non-nucleated dEs --- which are distributed like late-type galaxies --- S_N(dE,noN)=3.1 +- 0.5 and there is little or no trend with M_V. The S_N values for dE galaxies are thus on average significantly higher than those for late-type galaxies, which have S_N < 1. This suggests that dE galaxies are more akin to giant Es than to late-type galaxies. If there are dormant or stripped irregulars hiding among the dE population, they are likely to be among the non-nucleated dEs. Furthermore, the similarities in the properties of the globular clusters and in the spatial distributions of dE,Ns and giant Es suggest that neither galaxy mass or galaxy metallicity is responsible for high values of S_N. Instead, most metal-poor GCs may have formed in dwarf-sized fragments that merged into larger galaxies.Comment: 12 pages (uses aaspp4.sty), 2 figures, 1 table, to appear in the Astrophysical Journa

Engaging Students in the Basic Course By Asking Big Questions

This paper advocates for the inclusion of big questions into the basic course curriculum. It begins by exploring the nature of big questions as those that engage pressing and perennial civic and global issues, and details their effectiveness in encouraging students and faculty to think about interpersonal responsibility and social space as dynamically interfacing and mutually reflexive, thus challenging us to negotiate the civic call of engaging in democratic processes. The basic course, whether public speaking or hybrid, offers a crucial opportunity for big questions to emerge because it brings people together to critically question and produce messages about the social and civic contexts in which we all engage as students, faculty, employees, family, and citizens. Thus, the article includes examples from several basic course instructors and administrators of how big questions can be incorporated into the curriculum to enhance the learning outcomes of students, while at the same time situating the basic course as more deeply embedded into the stated mission and requirements of our departments, colleges, and general education programs

Analysis of Asymptomatic and Presymptomatic Transmission in SARS-CoV-2 Outbreak, Germany, 2020

We determined secondary attack rates (SAR) among close contacts of 59 asymptomatic and symptomatic coronavirus disease case-patients by presymptomatic and symptomatic exposure. We observed no transmission from asymptomatic case-patients and highest SAR through presymptomatic exposure. Rapid quarantine of close contacts with or without symptoms is needed to prevent presymptomatic transmission.Peer Reviewe

Validating a screening agar for linezolidresistant enterococci

Background: Linezolid is an alternative treatment option for infections with multidrug-resistant Gram-positive bacteria including vancomycin-resistant enterococci. Some countries report an increasing number of isolates with resistance to linezolid. The recent publication of the Commission for Hospital Hygiene in Germany on enterococci/VRE recommends screening for linezolid-resistant enterococci (LRE). However, a suitable selective medium or a genetic test is not available. Our aim was to establish a selective screening agar for LRE detection and validate its application with a comprehensive collection of clinical LRE and linezolid-susceptible enterococci. Methods: We decided to combine the selective power of an enterococcal screening agar with a supplementation of linezolid. Several rounds of analyses with reference, control and test strains and under varying linezolid concentrations of a wider and a smaller range were investigated and assessed. The collection of linezolid-resistant enterococcal control strains included isolates with different resistance mechanisms (23S rDNA mutations, cfr(B), optrA, poxtA). Finally, we validated our LRE screening agar with 400 samples sent to our National Reference Centre in 2019. Results: Several rounds of pre-tests and confirmatory analyses favored Enterococcosel® Agar supplemented with a concentration of 2 mg/L linezolid. A 48 h incubation period was essential for accurate identification of LRE strains. Performance of the LRE screening agar revealed a sensitivity of 96.6% and a specificity of 94.4%. Conclusions: Here we describe preparation of a suitable screening agar and a procedure to identify LRE isolates with high accuracyPeer Reviewe

Georgia Academy of Science, University of North Georgia, March 15th-16th, 2019

The annual meeting of the Georgia Academy of Science took place March 15–16, 2019, at the University of North Georgia in Oakwood. The keynote speaker was Dr. Marguerite Madden, Professor in the University of Georgia\u27s Department of Geography and Director of the Center for Geospatial Research. Her presentation was entitled Geospatial Technologies and Augmented Reality Spark Excitement in Science Education, Research and Outreach. Additional presentations were provided by members of the Academy who represented the following sections: I. Biological Sciences, II. Chemistry, III. Earth & Atmospheric Sciences, IV. Physics, Mathematics, Computer Science, Engineering, & Technology, V. Biomedical Sciences, VI. Philosophy & History of Science, VII. Science Education, and VIII. Anthropology