Complementary Sensory and Associative Microcircuitry in Primary Olfactory Cortex

The three-layered primary olfactory (piriform) cortex is the largest component of the olfactory cortex. Sensory and intracortical inputs converge on principal cells in the anterior piriform cortex (aPC).Wecharacterize organization principles of the sensory and intracortical microcircuitry of layer II and III principal cells in acute slices of rat aPC using laser-scanning photostimulation and fast two-photon population Ca²⁺ imaging. Layer II and III principal cells are set up on a superficial-to-deep vertical axis. We found that the position on this axis correlates with input resistance and bursting behavior. These parameters scale with distinct patterns of incorporation into sensory and associative microcircuits, resulting in a converse gradient of sensory and intracortical inputs. In layer II, sensory circuits dominate superficial cells, whereas incorporation in intracortical circuits increases with depth. Layer III pyramidal cells receive more intracortical inputs than layer II pyramidal cells, but with an asymmetric dorsal offset. This microcircuit organization results in a diverse hybrid feedforward/recurrent network of neurons integrating varying ratios of intracortical and sensory input depending on a cell’s position on the superficial-to-deep vertical axis. Since burstiness of spiking correlates with both the cell’s location on this axis and its incorporation in intracortical microcircuitry, the neuronal output mode may encode a given cell’s involvement in sensory versus associative processing

Gender disparities in pediatric research: a descriptive bibliometric study on scientific authorships

Background: The proportion of women in medicine, especially in pediatrics, is noticeably increasing. Yet, leadership positions are predominantly occupied by men. Methods: Academic authorships of 156,642 pediatric original research articles were analyzed with regard to gender disparities. The evaluation included the proportion of female authorships (FAP), distributions over first-, co- and last-authorships, gender-related citation rates, a productivity analysis and investigations on journals, countries and pediatric sub-disciplines. Results: In all, 46.6% of all authorships in pediatric research were held by female authors. Women held relatively more first-authorships (FAP = 52%) and had higher odds for first- (OR = 1.3) and co- (OR = 1.11) authorships, compared to men. The Prestige Index of −0.13 indicated an underrepresentation of female authors at prestigious first- and last-authorships. Citation rates were not affected by the gender of the key authors. At the country-level pronounced gender-related differences were detected. The time trend showed increasing female prospects forecasting a female-dominated Prestige Index of 0.05 in 2023. Conclusion: The integration of women in pediatric research has advanced. Opportunities for female authors differ at the country-level, but overall women are lacking in leadership positions. Improving career opportunities for women in pediatric research can be expected in the coming years. Impact: There is a measurable progress in the integration of female scientists. Gender-neutrality is partially achieved in pediatric research with yet a female underrepresentation in leading positions. Our descriptive study presents gender-related dynamics in pediatric research that forecast improving career opportunities for female scientists

Outpatient care in acute and prehospital emergency medicine by emergency medical and patient transport service over a 10-year period: a retrospective study based on dispatch data from a German emergency medical dispatch centre (OFF-RESCUE)

Background!#!The number of operations by the German emergency medical service almost doubled between 1994 and 2016. The associated expenses increased by 380% in a similar period. Operations with treatment on-site, which retrospectively proved to be misallocated (OFF-Missions), have a substantial proportion of the assignment of the emergency medical service (EMS). Besides OFF-Missions, operations with patient transport play a dominant role (named as ON-Missions). The aim of this study is to work out the medical and economic relevance of both operation types.!##!Methods!#!This analysis examined N = 819,780 missions of the EMS and patient transport service (PTS) in the catchment area of the emergency medical dispatch centre (EMDC) Bad Kreuznach over the period from 01/01/2007 to 12/31/2016 in terms of triage and disposition, urban-rural distribution, duration of operations and economic relevance (p < .01).!##!Results!#!53.4% of ON-Missions are triaged with the indication non-life-threatening patient transport; however, 63.7% are processed by the devices of the EMS. Within the OFF-Mission cohort, 78.2 and 85.8% are triaged or dispatched for the EMS. 74% of all ON-Missions are located in urban areas, 26% in rural areas; 81.3% of rural operations are performed by the EMS. 66% of OFF-Missions are in cities. 93.2% of the remaining 34% of operations in rural locations are also performed by the EMS. The odds for both ON- and OFF-Missions in rural areas are significantly higher than for PTS (OR!##!Conclusions!#!This study particularly highlights the increasing utilization of emergency devices; especially in OFF-Missions, the resources of the EMS have a higher number of operations than PTS. OFF-Missions cause immensely high costs due to misallocations from an economic point of view. Appropriate patient management appears necessary from both medical and economic perspective, which requires multiple solution approaches

Female authorships by journal category.

<p><b>(A)</b> The subject category <i>Earth & Environmental</i> has much favorable authorship odds for women than other categories. The number of considered male and female authorships is given in brackets. (B) In all categories, the FAP exhibits a positive annual growth with a relatively higher growth for first and last authorships and a relatively lower growth for co-authorships.</p

Female authorships by continents.

<p>The continents were descendingly ordered by the <i>Prestige Index</i>.</p

Classification of countries descendingly ordered by the Prestige Index.

<p>Classification of countries descendingly ordered by the Prestige Index.</p

Correlation of journal parameters.

<p>(A) There is no correlation between the 5-Year-Impact-Factor of a journal and its FAP. (B) A large negative correlation between the 5-Year-Impact-Factor of a journal and its <i>Prestige Index</i> was revealed. (C) The graph shows a small, but not significant negative correlation between the FAP and the <i>Prestige Index</i> of a journal.</p

Classification of <i>Multidisciplinary</i> journals.

<p>Classification of <i>Multidisciplinary</i> journals.</p

Female authorships by authors per article.

<p>The more authors contribute to an article, the higher is the FAP and the lower is the representation of women at prestigious authorships.</p

Linear projection of the development of female authorships on the global level.

<p>The prognosis for the next decades forecasts a slow harmonization of authorship odds between the two genders and the persistence of the unfavorable FAOR-pattern with a negative <i>Prestige Index</i>. A FAP of 33.1% is prognosticated for the year 2025.</p