City of Bend 2005-2006 action plan

24 pp. Bookmarks modified by UO. Table. Most recent activity 2005. Captured March 30, 2009.The City of Bend 2005-2006 Action Plan lists the specific activities the city will undertake during the 2005-2006 Program Year to meet the goals and objectives outlined in the Strategic Plan. The Plan details how the City will use CDBG funds, as well as other available resources, to address the City's outstanding housing and community development needs. [From the Plan

The Home Office and Public Disturbance, c. 1800-1832

This thesis examines the role of the Home Office in the machinery of order from c.1800-1832. It combines institutional enquiry with the study of popular protest by examining protest from the viewpoint of the Home Office. It looks at how the growth of the Home Office was stagnated due to efforts to economise, and how it transformed its systems to make them more efficient in response to peaks of administrative work caused by popular tumult. The different roles that each person performed in the Home Office is outlined, and by doing so the pivotal role of the permanent under-secretary of state, who remains underrepresented in histories of protest, is exposed. It also looks at what powers the home secretary had at his disposal, and how they were used to repress food riots, the Luddite disturbances, the movement for parliamentary reform, the Swing riots, political agitation leading to the Great Reform Act, and trade unions. It compares the different approaches of home secretaries and argues that although the use of powers was generally guided by established precedent, others such as domestic espionage were more divisive, and were influenced by the personality and experience of the home secretary. The thesis also examines the relationships between the Home Office hierarchy and government departments with authorities in the provinces. This thesis brings together all the available records which relate to the Home Office as an institution and those which relate to public disturbance. It demystifies the Home Office and its archives, presents a new analysis of Home Office powers and influence, and adds to our understanding of the way the machinery of order functioned, and the Home Office’s role within it. The thesis argues that the home secretary performed the role of overseer in the machinery of order; interjecting only when necessary when civil authorities failed to contain disturbances, or when the judiciary failed to provide a firm example. It contends that there were clear limits to state authority, contests claims of extraordinary state intervention, and argues that the state struggled to innovate to defeat the threats that the early nineteenth century presented

Hoynes Law School Award Latest at Notre Dame

Faculty and students resolve to celebrate Hoynes Night each year in perpetuity. William J. Hoynes, dean emeritus, establishes a $100 prize for the graduating student with the best deportment and highest academic performance. The award has been established by Col. Hoynes to perpetuate the high principles and the Notre Dame spirit of courage, perseverance, trustworthiness, self-reliance, manliness and steadfast moral character which he has always tried to instill in law students

Improved Limits on Spin-Dependent WIMP-Proton Interactions from a Two Liter CF3_3I Bubble Chamber

Data from the operation of a bubble chamber filled with 3.5 kg of CF$_{3}$I in a shallow underground site are reported. An analysis of ultrasound signals accompanying bubble nucleations confirms that alpha decays generate a significantly louder acoustic emission than single nuclear recoils, leading to an efficient background discrimination. Three dark matter candidate events were observed during an effective exposure of 28.1 kg-day, consistent with a neutron background. This observation provides the strongest direct detection constraint to date on WIMP-proton spin-dependent scattering for WIMP masses $>20$ GeV/c$^{2}$.Comment: 4 pages, 4 figures V2 submitted to match journal versio

Doctor of Philosophy

dissertationLipid membranes organize eukaryotic cells into functional compartments called organelles. Material is delivered to and from organelles in a regulated fashion. Vesicles bud from a source compartment, move across the cell and fuse with a target membrane. SNARE proteins, with Sec1/Munc18 (SM) proteins, drive the fusion of vesicles with their target by bridging the apposing membranes and forcing them together. The SNARE/SM fusion complex is essential for all vesicle fusion. Each trafficking pathway utilizes a different set of SNARE/SM family members. In the nervous system the secretory pathway is responsible for the release of neurotransmitters, which pass signals between neurons. The neuronal SNAREs include synaptobrevin, syntaxin, and SNAP-25. However, it is not clear that these are the only SNAREs responsible for neurotransmitter release. In fact countless studies have reported residual neurotransmission in the absence of each of these proteins, raising the question what is the mechanism responsible for residual fusion in neuronal SNARE knockouts? In Chapter 2, I explore this question by focusing on the neuronal SNARE SNAP-25. We characterize the snap-25 genetic locus in C. elegans and examine the physiology of neurons lacking the SNAP-25 protein. We find that SNAP-25 plays an important role in docking and fusing synaptic vesicles but is not strictly essential for either one. We reveal that the conserved SNARE protein, SNAP-29 is capable of substituting for SNAP-25 in synaptic vesicle fusion. We demonstrate that the SNAP-29 protein is natively expressed in neurons and localized at synapses. Our observations suggest that the canonical neuronal SNAREs may not act alone in releasing neurotransmitters. Finally, I explore the mechanism by which the neuronal SM protein (Unc18) facilitates fusion. Unc18 binds SNAREs in three configurations. A binary complex with syntaxin is important for trafficking. At nerve terminals, UNC-18 interacts with an N-terminal peptide on syntaxin and with the SNARE four-helix bundle. Our experiments demonstrate that the N-peptide of syntaxin is a passive tether facilitating Unc18's transition from the binary syntaxin interaction to a direct interaction with the ternary SNARE complex. Future work is required to elucidate the fusogenic properties of Unc18's interaction with the ternary complex