Maxillofacial metastasis from breast cancer

Metastatic tumors to paranasal sinuses are exclusively rare. In this paper, we report acase of breast  carcinoma metastasizing to the right maxilla. The metastasis occurred 5 years after radical mastectomy and presented as a primary sinonasalmass. The diagnosis was confirmed with histopathologic  andimmunohistochemical examination however the patient died before starting any specific treatment  because of tumor bleeding.Key words: Breast cancer, maxillofacial, metastasi

Para testicular rhabdomyosarcoma in adults: three case reports and review of literature

Paratesticular embryonal rhabdomyosarcoma (RMS) is a rare tumor arising from the mesenchymal tissues of the spermatic cord, epididymis, testis and testicular tunics. We report three cases of adult paratesticular RMS, two embryonic and one pleomorphic rhabdomyosarcoma. All the patients underwent diagnostic orchidectomy. The work up investigations revealed lung metastases. Chemotherapy with Ifosfamide and Doxorubicin was used in two cases, whereas Vincristin- Actinomycin D and Cyclophosphamide was received in one case. An objective partial response was reported in 2 cases, with complete response in one case. Paratesticular RMS is a rare and aggressive tumor. Because of the absence of protocols designed specifically for adult patients, it is necessary to follow therapeutic guidelines in pediatric protocols

A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy

Fibrosarcomas (FS) of bone are a rare malignancy accounting for less than 5% of all primary malignant bone neoplasms. Diagnosis and treatment approaches of this entity are complex and require a skilled and experienced multidisciplinary team

EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis

Abstract Background Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations. Methods We used PubMed and the Cochrane Library databases to conduct a literature search using the terms “[EGFR] AND [mutation] AND [Non Small Cell Lung Cancer] AND [Middle East OR Africa].” We assessed studies published in English and French from 2004 until 2016. Results Ten relevant studies were included in this systematic review. Overall, 1215 patients with non-small cell lung cancer (NSCLC) were included in this analysis. The overall ratio of male to female patients was 2.15. Of total patients included, 41.1% had never smoked and 85.8% had been diagnosed with adenocarcinoma. In 8 of the 10 studies, polymerase chain reaction (PCR) analyses were conducted to identify EGFR mutations. In total, 257 patients had an EGFR mutation, corresponding to a prevalence of 21.2%. The most frequent abnormality detected in all of the studies was in exon 19. In addition, all studies concluded the presence of a correlation between EGFR mutation status and female sex, non-smoking status, and adenocarcinoma subtype. Conclusions The EGFR mutation frequency in Middle East and African patients is higher than that shown in white populations but still lower than the frequency reported in Asian populations

Focus on the ethnobotany of north Moroccan sage, false yellowhead, and carrot: insights into their pharmacological potential

Introduction: Medicinal plants, including spontaneous or cultured herbaceous and forest products, represent an inexhaustible source of traditional and effective remedies thanks to their active major compounds. The present work consists of an ethnobotanical study of three species namely, Daucus carota, Dittrichia viscosa, and Salvia officinalis, commonly used in Taounate region (Northern Morocco) to treat various diseases. Methods: An ethnopharmacological survey was conducted in Taounate region during a period of three months from January to March 2022, using semi-structured individual interviews. Then, the collected data were analyzed statistically using Microsoft Office software "Excel 2013" and System Package for Social Sciences (SPSS). Results: Leaves, flowers, and stems were the most common parts used to prepare traditional remedies. Decoction, infusion, and cataplasm were the most used preparation methods, and the oral route was the most common method of administration for the studied plants. Moreover, the plants intervened in the treatment of digestive, genito-urinary, dermatological, neurological, and metabolic diseases. Conclusion: Information collected during this study shed light on the interesting know-how in traditional herbal medicine in the study area, and on the frequent use of medicinal plants as an alternative to synthetic drugs by the population of Taounate, to treat different diseases. Thereafter, the study’s results can constitute an important database for pharmacologists, phytochemists, toxicologists, and clinical researchers for the development of new drugs based on natural substances

Primitive Neuroectodermal Tumor of the Cervix Uteri

Ewing’s sarcoma is a round cell malignancy of bone and soft tissue that occurs predominately in adolescents and young adults.It is an uncommon malignancy, but is recognized as the second most prevalent primary bone tumor worldwide. Extraosseous Ewing’s sarcoma is extremely rare and can affect the skin, soft tissues, or viscera. Prognostic and therapeutic features of Ewing’s extraosseous tumors are similar to those of Ewing’s sarcoma. A primary Ewing’s sarcoma arising from the cervix is highly rare. Most of these patients presented with abnormal vaginal bleeding. We report a case of extraskeletal Ewing’s sarcoma arising in the cervix in a 25-year-old woman