Qualitative and quantitative phytochemical analysis of different extracts from Thymus algeriensis aerial parts

This study was performed to evaluate the metabolite recovery from different extraction methods applied to Thymus algeriensis aerial parts. A high-performance liquid chromatographic method using photodiode array detector with gradient elution has been developed and validated for the simultaneous estimation of different phenolic compounds in the extracts and in their corresponding purified fractions. The experimental results show that microwave-assisted aqueous extraction for 15 min at 100 C gave the most phenolics-enriched extract, reducing extraction time without degradation effects on bioactives. Sixteen compounds were identified in this extract, 11 phenolic compounds and five flavonoids, all known for their biological activities. Color analysis and determination of chlorophylls and carotenoids implemented the knowledge of the chemical profile of this plant

Crystal structure of 7,7-dimethyl-6-methylidenetricyclo[6.2.1.01,5]undecane-2-carboxylic acid

In the title compound, C15H22O2, both five-membered rings display an envelope conformation whereas the six-membered ring displays a chair conformation. In the crystal, pairs of O-H...O hydrogen bonds between carb­oxy­lic groups link mol­ecules, related by a twofold rotation axis, into supra­molecular dimers

Ethanol Induced Toxicity and Lipid Peroxidation in Pregnant Mice: Protective Effects of Butanolic Extract from Leaves of Chrysanthemum fontanesii, Vitamin E and C

Background: The objective of the present study was to investigate the ability of butanolic extract from leaves of Chrysanthemum fontanesii, vitamin E and C to modulate ethanol-Induced toxicity and oxidation damage in maternal and fetal tissues of mice. Butanolic extract from leaves of Chrysanthemum fontanesii (200 mg/Kg per day), vitamin E (100mg/Kg per day) and C (8.3mg/Kg per day) were administered by gavage to groups of pregnant mice from the 6 th to 17 th day of gestation. A number of animals received plant extract, vitamin E and C, also treated with an oral administration of ethanol (0.02ml/g of 25% v/v absolute ethanol in water per day) in same conditions. On day 18 of gestation, pregnant mice were killed, fetus, placenta, fetal liver, liver, kidneys and brain were removed, homogenised and used for determination of lipid peroxidation (LPO) using TBARS method. Embryotoxicity was assessed by counting the number of live and dead fetus and growth retardation. Results: Severe alterations in all biomarkers were observed after injury with ETOH. ETOH produced significant decreases in fetal weight and significant increases in embryolethality and lipid peroxidation relative to control values. Treatment with Chrysanthemum fontanesii extract, vitamin C and vitamin E resulted in markedly decreased embryolethality and fetal growth retardation, while increased fetal weight were observed. Conclusion: The butanolic extract from leaves of Chrysanthemum fontanesii, vitamin E and C protected against ethanol induce fetal and maternal toxicity as revealed by the decrease in the extent of lipid peroxidation. So that butanolic extract from leaves of Chrysanthemum fontanesii posses in vivo antioxidant properties

Crystal structure of pseudoguainolide

The lactone ring in the title mol­ecule, C15H22O3 (systematic name: 3,4a,8-tri­methyl­dodeca­hydro­azuleno[6,5-b]furan-2,5-dione), assumes an envelope conformation with the methine C atom adjacent to the the methine C atom carrying the methyl substituent being the flap atom. The other five-membered ring adopts a twisted conformation with the twist being about the methine-methyl­ene C-C bond. The seven-membered ring is based on a twisted boat conformation. No specific inter­actions are noted in the the crystal packing

Atriplex mollis desf. Aerial parts: extraction procedures, secondary metabolites and color analysis

A method using high-performance liquid chromatography coupled with a photodiode array detector was proposed for the rapid characterization of different phenolic constituents from the extracts of Atriplex mollis aerial parts. Atriplex species are known for their multiple biological activities, but no information is available in the literature about A. mollis. With the aim to firstly characterize the main secondary metabolites of this plant, so as to orient better the biological evaluation, we applied three different extraction procedures and compared the chromatographic results. Microwave-assisted extraction gave the best yield and recovery of important compounds such as gallic acid, catechin, chlorogenic acid, p-OH benzoic acid, rutin, sinapinic acid, t-ferulic acid, naringenin and benzoic acid. These constituents belong to three important chemical classes: phenolic acids, flavonoids and monoterpenes. Color evaluation and analysis of chlorophylls (a and b) and carotenoids complete the preliminary profile of this plant. From these analyses, Atriplex mollis is a source of bioactive compounds (especially rutin, t-ferulic acid and gallic acid) and could be recommended as a plant of phyto-pharmaceutical relevance, opening new perspectives on this salt-tolerant plant

One Pot Synthetic Method of New Keto Diphenyl Selenide Compounds

Abstract: A series of hitherto unreported mono-and di-keto diphenyl selenides have been efficiently synthesized in high yields by treatment of diphenyl selenide (1) with appropriately substituted acyl chloride using anhydrous aluminum chloride as catalyst and methylene chloride as solvent. The structures of the synthesized compounds have been confirmed by elemental and spectral analysis

Antioxidant and antibacterial activity of extract and phases from stems of Spartium junceum L. growing in Algeria

This work aimed to evaluate the antioxidant and antibacterial activities of the hydroalcoholic (80% methanol) extract and n-hexane (n-Hex), chloroform (Chl), ethyl acetate (EtAc), and n-butanol (n-But) phases from Spartium junceum L. stems collected inAlgeria. Preliminary phytochemical investigations on phenolic compounds have been carried out.The total phenolic content, spectrophotometrically determined, ranged from 71.8095 ± 3.7136 mg GAE/g (extract) to 0.0582 ± 0.0106 mg GAE/g (n-Hex). By HPLC-PDA analysis flavonoids (flavone derivatives), p-hydroxybenzoic acid, p-hydroxycinnamic acid, and cinnamic acid derivatives were identified both in the extract and phases.S. junceum extract showed a noticeable free radical scavenging effect in the DPPH test (IC50 = 0.6833 ± 0.0240 mg/mL), mild reducing power, and strong chelating activity (IC50 = 0.2292 ± 0.0138 mg/mL). Among the phases, n-But displayed the best effect both in the DPPH test and reducing power assay, whereas n-Hex resulted the most active in the ferrous ions chelating activity assay. A positive relationship between DPPH radical scavenging activity and total phenolic content was found. Both the extract and phases exhibited antimicrobial activity against Gram-positive bacteria only. Staphylococcus aureus ATCC 6538 was the most susceptible strain (MIC range: 15.60-250.00 µg/mL), and the Chl phase showed the greatest efficacy. S. junceum extract resulted non-toxic against Artemia salina.The obtained results demonstrate the potential of S. junceum stems as safe sources of natural antioxidant and antimicrobial compounds

LA VEILLE IMAGE AU SERVICE DE L’E-REPUTATION : UNE ETUDE EXPLORATOIRE DANS LE CONTEXTE MAROCAIN

Avec l’apparition d’Internet, les entreprises sont confrontées à une nouvelle contrainte qui repose sur leurs images en ligne risquant d’affecter leurs réputations électroniques. Pour ce faire, celles-ci doivent être dotées d’un outil puissant permettant d’anticiper les signaux faibles et être à l’écoute de leurs écosystèmes .Cet article a pour objet d’étudier la « veille image sur Internet »et son corollaire l’e-réputation. A la lumière de 32 entretiens semi directifs réalisés auprès des internautes et auprès des écoles primaires, nous nous proposons de réaliser une étude exploratoire qui traite deux principaux axes, d’une part, l’influence des réseaux sociaux dans la construction de l’image chez les internautes d’autre part, le rôle de la veille image dans la gestion de la e-réputation.