253 research outputs found
Characteristic Neural Firing Profiles in Different Hippocampal Subfields for Successful and Unsuccessful Memory
Memory is our ability to encode, store, retrain, and subsequently recall information and
past experiences. Different areas of the brain are responsible for different aspects of memory,
including the hippocampus which enables us to form, organize, and store new memories.
Numerous research studies show that the hippocampal subfields are affected by memory related
diseases such as Alzheimer’s Disease and Schizophrenia in different ways. Understanding what
the different hippocampal subfields do is important for basic science, but also for understanding
neurodegenerative disorders which are associated with structural and functional abnormalities of
hippocampal neurons. In order to examine the effects of memory success and failure of the
firing patterns of the hippocampal neurons in the different subfields, I used a unique dataset,
published by Faraut et al (2018), of a large sample of intracranial neural spiking data from
humans.) and ran a hierarchical clustering algorithm on the neural firing patterns. Results
suggest that the neurons in the different hippocampus subfields (CA1, CA2, CA3, and DG) have
certain firing profiles which as a result causes them to group together according to these specific
subfields. These firing patters were different in some degree depending on weather on successful
and unsuccessful memory – and thus suggest each subfield processes memories in a different
way.Undergraduat
Attractor Modulation and Proliferation in 1+ Dimensional Neural Networks
We extend a recently introduced class of exactly solvable models for
recurrent neural networks with competition between 1D nearest neighbour and
infinite range information processing. We increase the potential for further
frustration and competition in these models, as well as their biological
relevance, by adding next-nearest neighbour couplings, and we allow for
modulation of the attractors so that we can interpolate continuously between
situations with different numbers of stored patterns. Our models are solved by
combining mean field and random field techniques. They exhibit increasingly
complex phase diagrams with novel phases, separated by multiple first- and
second order transitions (dynamical and thermodynamic ones), and, upon
modulating the attractor strengths, non-trivial scenarios of phase diagram
deformation. Our predictions are in excellent agreement with numerical
simulations.Comment: 16 pages, 15 postscript figures, Late
An associative network with spatially organized connectivity
We investigate the properties of an autoassociative network of
threshold-linear units whose synaptic connectivity is spatially structured and
asymmetric. Since the methods of equilibrium statistical mechanics cannot be
applied to such a network due to the lack of a Hamiltonian, we approach the
problem through a signal-to-noise analysis, that we adapt to spatially
organized networks. The conditions are analyzed for the appearance of stable,
spatially non-uniform profiles of activity with large overlaps with one of the
stored patterns. It is also shown, with simulations and analytic results, that
the storage capacity does not decrease much when the connectivity of the
network becomes short range. In addition, the method used here enables us to
calculate exactly the storage capacity of a randomly connected network with
arbitrary degree of dilution.Comment: 27 pages, 6 figures; Accepted for publication in JSTA
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