Additional file 1: of Is there an added value of faecal calprotectin and haemoglobin in the diagnostic work-up for primary care patients suspected of significant colorectal disease? A cross-sectional diagnostic study

Supplementary appendix. Contents: interaction between POC FIT and overt rectal bleeding; Table S1: model development strategy and specification; Table S2: reclassification table combined POC extended model versus basic diagnostic model; Table S3: reclassification table POC FIT extended model versus basic diagnostic model; Table S4: optimism corrected parameters for the basic model, the calprotectin POC extended model, the calprotectin ELISA extended model, and the calprotectin ELISA and POC FIT extended model; Figure S1: calibration curves; Figure S2: decision curve analysis; Figure S3: ROC curves subsitituting calprotectin POC with ELISA; Figure S4: nomogram of the combined POC extended model; Figure S5: nomogram of the POC FIT extended model. (DOCX 2031 kb

Additional file 1: of Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Definitions of secondary endpoints. Table S1. Severity of PEP according to Cotton and revised Atlanta criteria. Table S2. Local and systemic complications according to (revised) Atlanta criteria. Table S3. ERCP-related complications (adopted from Cotton). SPIRIT checklist. (DOCX 40 kb

Additional file 1: of Multimodal treatment of perianal fistulas in Crohn’s disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial

Dates of consent of participating centres

Additional file 1: Figure S1. of Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial

Flowchart APEC trial according to CONSORT [43]. (PDF 6 kb

Additional file 3: Table S1. of Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial

Definitions of the primary endpoint. (DOC 35 kb