Dark Matter Halos within Clusters

We examine the properties of dark matter halos within a rich galaxy cluster using a high resolution simulation that captures the cosmological context of a cold dark matter universe. The mass and force resolution permit the resolution of 150 halos with circular velocities larger than 80 kms within the cluster's virial radius of 2 Mpc. This enables an unprecedented study of the statistical properties of a large sample of dark matter halos evolving in a dense environment. The cumulative fraction of mass attached to these halos varies from 0% at 200 kpc, to 13% at the virial radius. Even at this resolution the overmerging problem persists; halos that pass within 200 kpc of the cluster center are tidally disrupted. Additional substructure is lost at earlier epochs within the massive progenitor halos. The median ratio of apocentric to pericentric radii is 6:1; the orbital distribution is close to isotropic, circular orbits are rare, radial orbits are common. The orbits of halos are unbiased with respect to both position within the cluster and with the orbits of the smooth dark matter background and no velocity bias is detected. The tidal radii of surviving halos are generally well-fit using the simple analytic prediction applied to their orbital pericenters. Halos within clusters have higher concentrations than those in the field. Within the cluster, halo density profiles can be modified by tidal forces and individual encounters with other halos that cause significant mass loss - ``galaxy harassment''. Mergers between halos do not occur inside the clusters virial radius.Comment: LaTeX MN style, 20 pages, 30 figures included + 1 colour plo

Achieving Optimal Value of Solar: A Municipal Utility Rate Analysis

Wind and solar renewable energy in the United States is projected to triple by 2050 to nearly 30% of total electric energy generation. The upper Midwest region (Iowa, Minnesota, and North and South Dakota in particular) is considered wind energy country and not historically known for solar energy development. In this work, Value of Solar (VOS) is developed as a photovoltaic (PV) optimization measure and analysis tool using a northwest Iowa municipality as a representative case study. By applying a top-down load duration curve system analysis, VOS is used to optimize PV orientation and compare electric rate structures for increasing levels of total PV energy contribution. VOS of a fixed south-southwest orientation exceeds the levelized annual costs of installation with a larger net benefit than a one-axis-tracking solar system. Production-data modeled VOS is up to 12% higher than Typical Meteorological Year (TMY) predictions, indicating significant correlation between PV generation and peak municipal demand. Compared to alternative time-of-use rates, a demand/energy rate structure better matches VOS economic value and optimal orientation. This VOS methodology is an easy-to-use yet meaningful tool for municipalities and smaller utilities to evaluate strategic installation of and investment in PV for their local community

Net-Zero Energy Districts and the Grid: An Energy-Economic Feasibility Case-Study of the National Western Center in Denver, CO, USA

Given the enormous impact of buildings on energy consumption, it is important to continue the development of net-zero energy districts. Opportunities exist for energy efficiency and renewable energy on a district level that may not be feasible in individual buildings. Due to the intermittent nature of many renewable energy sources, net-zero energy districts are dependent on the energy grid. The novelty of this work is to quantify and optimize the economic cost and grid independence of a net-zero energy district using the National Western Center (NWC) in Denver, CO, USA as a case study. The NWC is a 100+ ha campus undergoing a major redevelopment process with a planned 170,000 m2 of total building space, an emphasis on sustainability, and a net-zero energy goal. Campus plans, building energy models, and renewable energy performance models of on-site solar, biomass, and thermal renewable energy sources are analyzed in multiple energy scenarios to achieve net-zero energy with and without on-site energy storage. Levelized cost of energy (LCOE) is optimized as a function of variables defining the energy and economic relationship with the grid. Discussion herein addresses trade-offs between net-zero energy scenarios in terms of energy load, LCOE, storage, and grid dependence

The Role of Transport and Telecommunications Technology in the Development of the Scottish Highlands and Islands Medical Service : A Historical Perspective

Peer reviewedPublisher PD

Nocebo Hyperalgesia, Partial Reinforcement, and Extinction

Many studies have found evidence of conditioning-induced nocebo hyperalgesia. However, these studies have exclusively involved continuous reinforcement schedules. Thus, it is currently unknown whether nocebo hyperalgesia can result following partial reinforcement. We tested this using electrodermal pain stimulation in healthy volunteers. Undergraduates (n=135) received nocebo treatment under the guise of a hyperalgesic. Participants were randomly allocated to continuous reinforcement (CRF), partial reinforcement (PRF), or control (no conditioning). Conditioning involved surreptitiously increasing pain stimulation on nocebo trials relative to control trials. During training, the CRF group always had the nocebo paired with the surreptitious pain increase, whereas the PRF group only experienced the increase on 62.5% of nocebo trials. In the test phase, pain stimulation was equivalent across nocebo and control trials. Partial reinforcement was sufficient to induce nocebo hyperalgesia, however, this was weaker than continuous reinforcement. Interestingly, nocebo hyperalgesia failed to extinguish irrespective of the training schedule. Additional assessment of expectancies indicated strong concordance between these and nocebo hyperalgesia. Overall, these findings suggest that once established, nocebo hyperalgesia may be difficult to disrupt. As such, partial reinforcement may be one method of reducing the intensity of nocebo hyperalgesia in the clinic, which may be particularly important given its persistence. Perspectives: This study provides novel evidence that partial reinforcement results in weaker nocebo hyperalgesia than continuous reinforcement and that nocebo hyperalgesia fails to extinguish, irrespective of the training schedule. As a result, partial reinforcement may serve as a method for reducing the intensity of nocebo hyperalgesia in the clinic

Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation

peer-reviewedData Availability: The raw sequencing reads (FASTQ files) and sequence read counts mapped to UCSC hg19 for each of the 74 transcriptomes sequenced in this study have been deposited at Gene Expression Omnibus (GEO) accession GSE69549.This project was funded by Science Foundation Ireland Grant number 09/IN.1/B2640 to RM.Genetic studies have to date identified 43 genome wide significant coeliac disease susceptibility (CD) loci comprising over 70 candidate genes. However, how altered regulation of such disease associated genes contributes to CD pathogenesis remains to be elucidated. Recently there has been considerable emphasis on characterising cell type specific and stimulus dependent genetic variants. Therefore in this study we used RNA sequencing to profile over 70 transcriptomes of CD4+ T cells, a cell type crucial for CD pathogenesis, in both stimulated and resting samples from individuals with CD and unaffected controls. We identified extensive transcriptional changes across all conditions, with the previously established CD gene IFNy the most strongly up-regulated gene (log2 fold change 4.6; Padjusted = 2.40x10-11) in CD4+ T cells from CD patients compared to controls. We show a significant correlation of differentially expressed genes with genetic studies of the disease to date (Padjusted = 0.002), and 21 CD candidate susceptibility genes are differentially expressed under one or more of the conditions used in this study. Pathway analysis revealed significant enrichment of immune related processes. Co-expression network analysis identified several modules of coordinately expressed CD genes. Two modules were particularly highly enriched for differentially expressed genes (P</iframe

Latent Inhibition Reduces Nocebo Nausea, Even Without Deception

Background: Nocebo nausea is a debilitating and prevalent side effect that can develop after conditioning occurs between cues present in the treatment context and the experience of nausea. Interventions that retard conditioning may therefore be able to reduce nocebo nausea. Purpose: To test whether ‘latent inhibition’, where pre-exposing cues in the absence of an outcome retards subsequent learning about those cues, could reduce nocebo nausea in healthy adults. Methods: We examined this possibility using a Galvanic Vestibular Stimulation (GVS) model of nausea in healthy participants, with pre-exposure to the treatment cues achieved using a placebo version of GVS. Results: In Experiment 1 we found clear evidence of conditioned nocebo nausea that was eradicated by latent inhibition following pre-exposure to placebo stimulation. Experiment 2 tested whether deception, which may be unethical in clinical settings, was necessary to produce latent inhibition by including an open pre-exposure group informed they were pre-exposed to placebo stimulation. Experiment 2 replicated the latent inhibition effect on nocebo nausea following deceptive pre-exposure from Experiment 1 and found that open pre-exposure was just as effective for reducing nocebo nausea. In both experiments, there was an interesting discrepancy found in expectancy ratings whereby expectations appeared to drive the development of conditioned nocebo nausea, but were not responsible for its retardation through latent inhibition. Conclusions: These findings have significant clinical implications. Applying open pre-exposure in clinical settings may effectively and ethically reduce the development of nocebo effects for nausea and other conditions via latent inhibition