Probing particle-phonon-coupled states in the neutron-rich nucleus Cu-65 by lifetime measurements with fast-timing techniques

The Cu-65 nucleuswas populated by the Ni-64(Li-7,alpha 2n)Cu-65 reaction and the lifetime of the 9/2(+) state at 2.5 MeV was measured by electronic fast-timing technique, providing the value tau = 37(3) ps. The reduced transition probability B(E3) = 8.82(165) W.u. is deduced and compared to theoretical predictions in the framework of a particle-vibration (weak) coupling model. The results indicate that the 9/2(+) state is a member of the 3(-)circle times pi p3/2 multiplet, built by coupling the octupole 3(-) phonon of Ni-64 to an unpaired proton in the p(3/2) level, confirming the robustness of core excitations in the medium mass nucleus Ni-64

Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men

OBJECTIVE: The receptor for advanced glycation end products (RAGE) is a cell surface receptor whose signaling pathway has been implicated in atherogenesis. RAGE has an endogenous secretory receptor form, called soluble RAGE (sRAGE), that could exert antiatherogenic effects by acting as a decoy. We sought to determine whether a decreased plasma level of sRAGE could be independently associated with the prevalence of coronary artery disease (CAD) in nondiabetic men. METHODS AND RESULTS: Plasma levels of sRAGE were determined in 328 nondiabetic male patients with angiographically proved CAD and in 328 age-matched healthy controls. The concentration of sRAGE in plasma was significantly lower (P<0.0001) in CAD cases [median (interquartile range): 966 (658-1372) pg/mL] than in control subjects [1335 (936-1954) pg/mL]. In logistic regression analysis, the multivariate-adjusted odds ratio for the presence of CAD was 6.719 (95% confidence interval, 3.773 to 11.964; P<0.0001) when the lowest quartile of the sRAGE level was compared with the highest quartile. CONCLUSIONS: Our findings indicate that low levels of sRAGE in plasma are independently associated with the presence of CAD in nondiabetic men and suggest that sRAGE is one of the clinically important molecules associated with atherosclerosis

Electrocardiographic criteria of true left bundle branch block: a simple sign to predict a better clinical and instrumental response to CRT.

Background: Cardiac resynchronization therapy (CRT) has proved to be very effective in improving morbidity and mortality in patients affected with severe congestive heart failure. Its efficacy has been shown to be greater in patients with left bundle branch block (LBBB). The aim of our study was to verify if newly proposed criteria for true LBBB identify patients with a better clinical and instrumental response to CRT. Methods: Between May 2007 and April 2011, 111 patients with left ventricular ejection fraction (LVEF) ≤ 35% and LBBB morphology received a CRT device and were divided into two groups according to QRS morphology. Group 1 (61 patients) consisted of patients with “true” LBBB morphology; group 2 (50 patients) consisted of patients with “false” LBBB. The primary endpoint was the utility of criteria for true LBBB to predict a composite endpoint of all-cause mortality and hospital admission with heart failure. The secondary endpoint was the utility of the same criteria to predict an absolute increase in LVEF ≥ 10%. Results: “False” LBBB morphology and a dose of bisoprolol &lt;5 mg at last follow-up were the only parameters related to clinical outcome in multivariate analysis (respectively: hazard ratio [HR] 3.98, confidence interval [CI] 95% 1.51–10.48; HR 0.15, CI 95% 0.05–0.43). “True” LBBB morphology was the only variable significantly related to a greater increase in LVEF (HR 4.57, CI 95% 1.36–8.28). Conclusion: True LBBB morphology is related to a higher event-free survival rate in CRT patients and better echocardiographic response