34 research outputs found

    Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects

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    Background: High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses in healthy subjects. Methods: This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures were calculated. Results: The AUC0āˆ’10hrAUC_{0-10 hr} and CmaxC_{max} values increased nonlinearly between 100 mg and 1500 mg. The slope of the AUC0āˆ’10hrAUC_{0-10 hr} vs dose, as well as the CmaxC_{max} vs dose, plots are steepest at the lowest thiamine doses. Conclusion: Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process

    Continuous Freezecasting

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    In electric vehicle manufacturing, battery electrodes are made using roll-to-roll manufacturing, a continuous process in which an electrode mixture is moved along a roller-based processing line. It is efficient and cost-effective. Freeze casting is a process used to manufacture ceramic materials by using a temperature gradient to cast. The gradient aligns the grains in such a way that makes the material very conductive. The goal of this project is to design a mechanism to allow continuous freeze casting to be used in electrode manufacturing.Wenda TanUM Mechanical Engineering departmenthttp://deepblue.lib.umich.edu/bitstream/2027.42/192012/1/UM_Tan_F23_Team08_Continous-Freeze-Casting.pd

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