Muon-Spin Rotation Spectra in the Mixed Phase of High-T_c Superconductors : Thermal Fluctuations and Disorder Effects

We study muon-spin rotation (muSR) spectra in the mixed phase of highly anisotropic layered superconductors, specifically Bi_2+xSr_2-xCaCu_2O_8+delta (BSCCO), by modeling the fluid and solid phases of pancake vortices using liquid-state and density functional methods. The role of thermal fluctuations in causing motional narrowing of muSR lineshapes is quantified in terms of a first-principles theory of the flux-lattice melting transition. The effects of random point pinning are investigated using a replica treatment of liquid state correlations and a replicated density functional theory. Our results indicate that motional narrowing in the pure system, although substantial, cannot account for the remarkably small linewidths obtained experimentally at relatively high fields and low temperatures. We find that satisfactory agreement with the muSR data for BSCCO in this regime can be obtained through the ansatz that this ``phase'' is characterized by frozen short-range positional correlations reflecting the structure of the liquid just above the melting transition. This proposal is consistent with recent suggestions of a ``pinned liquid'' or ``glassy'' state of pancake vortices in the presence of pinning disorder. Our results for the high-temperature liquid phase indicate that measurable linewidths may be obtained in this phase as a consequence of density inhomogeneities induced by the pinning disorder. The results presented here comprise a unified, first-principles theoretical treatment of muSR spectra in highly anisotropic layered superconductors in terms of a controlled set of approximations.Comment: 50 pages Latex file, including 10 postscript figure

Pharmacoepidemiological aspects of antibacterial therapy of salpingoophoritis in hospital settings

The purpose of the study is an analysis of the consumption of antibacterial drugs in the therapy of salpingoophoritis in hospital settings and evaluation of changes in the real clinical practice of antibiotic therapy after the introduction of the "Order of medical care for the profile "obstetrics and gynecology⋯". Materials and methods. In a retrospective study, an assessment was made of the prescriptions of antibacterial drugs in the therapy of salpingoophritis in specialized treatment and prophylactic institutions of the city of Tomsk in the period 2010-2014. The analysis included 160 case histories. The structure of prescriptions was evaluated on the basis of the application of anatomical-therapeutic-chemical classification and international non-proprietary names (INN), the structural improvement factor K. Gatev was calculated. To quantify the consumption of medications, the calculated daily dose (PDD) was used. Results. Comparative analysis of antibacterial therapy of salpingoophoritis in hospital before and after the introduction of the "Order of medical care for the profile of "obstetrics and gynecology⋯". Leading groups of antibacterial drugs were identified. A comparative analysis of the frequency of assignment of various INN was made. The K. Gate's coefficient was 0.281. The calculation of the average prescribed daily doses of antibacterial drugs was performed. Conclusion. The review of the consumption of antibacterial drugs for salpingoophoritis therapy in hospital settings before and after the introduction of the "Order of medical care for the profile "obstetrics and gynecology⋯", showed that the range of antibacterial drugs used increased from 18 to 24 INN, mainly due to the inclusion of modern medicines. In the structure of appointments in 2013-2014, the proportion of drugs not recommended for use by the «Order of medical care» for the profile of «obstetrics and gynecology» was 37.5%. It was found that PDD clarithromycin, clindamycin and cefotaxime did not meet the recommended dosing regimens specified in the clinical recommendations for antibiotic therapy. The gap between actual clinical practice and existing clinical recommendations determines the need for in-depth pharmacoepidemiological evaluation to identify the causes and develop measures of an organizational and educational nature to optimize the use of medications. © 2018 Siberian State Medical University. All rights reserved

Fixed trandolapril and verapamil SR combination effectiveness in arterial hypertension patients

Aim. To study the effectiveness, rates of target blood pressure (BP) level achievement, and safety of a fixed-dose trandolapril and verapamil SR combination (Tarka) in patients with Stage I-II arterial hypertension (AH). Material and methods. The study initially included 100 AH patients; 7 dropped out, and 4 were excluded due to inclusion criteria violation. The study protocol was completed by 89 participants (36% men, 64% women), aged 27-74 years (mean age 56,6 10,8 years), with mean AH duration of 9,1 8 years. After 3-14-day wash-out period, clinical mean systolic BP (SBP clin.) level was 158,1 +/- 9,3/95,1 +/- 8,0 mm Hg, and heart rate (HR) level - 75,2 +/- 7,4 bpm. BP level corresponded to Stage I AH in 40,5% of the patients, and to Stage 11 AH - in 59,5%. Eighty five per cent of the participants received anti hypertensive medications, 17% had Type 2 diabetes mellitus (DM-2), 20% were smokers. Results. In all patients, Tarka therapy (2/180 mg/d) was associated with adequate BP reduction. Antihypertensive effect reached its maximum at Week 4 of the treatment. Twelve-week therapy resulted in significant decrease in BP clin., (Delta=-28,9 +/- 11,0/-18,4 +/- 8,1; p < 0,001) and HR (Delta=-6,0 +/- 6,6; p < 0,0001). Target SBP, DBP or SBP+DBP levels were achieved in 82%, 96%, and 80%, respectively. In DM-2 patients, target BP level was achieved in 71%. According to 24-hour BP monitoring data, after 12 weeks of treatment, BP was normalized in 68 participants: in 88% - for SBP, in 99% - for DBP, and in 88% - for both SBP and DBP. In all patients, the treatment was well tolerated; adverse effects (A-E) were registered in 9 individuals only. Conclusion. Good antihypertensive effectiveness of fixed trandolapril and verapamil combination facilitated target BP level achievement in 80% of the patients, with low AE rates. Therefore, the medication could be recommended at initial treatment stage

Fixed trandolapril and verapamil SR combination effectiveness in arterial hypertension patients

Aim. To study the effectiveness, rates of target blood pressure (BP) level achievement, and safety of a fixed-dose trandolapril and verapamil SR combination (Tarka) in patients with Stage I-II arterial hypertension (AH). Material and methods. The study initially included 100 AH patients; 7 dropped out, and 4 were excluded due to inclusion criteria violation. The study protocol was completed by 89 participants (36% men, 64% women), aged 27-74 years (mean age 56,6 10,8 years), with mean AH duration of 9,1 8 years. After 3-14-day wash-out period, clinical mean systolic BP (SBP clin.) level was 158,1 +/- 9,3/95,1 +/- 8,0 mm Hg, and heart rate (HR) level - 75,2 +/- 7,4 bpm. BP level corresponded to Stage I AH in 40,5% of the patients, and to Stage 11 AH - in 59,5%. Eighty five per cent of the participants received anti hypertensive medications, 17% had Type 2 diabetes mellitus (DM-2), 20% were smokers. Results. In all patients, Tarka therapy (2/180 mg/d) was associated with adequate BP reduction. Antihypertensive effect reached its maximum at Week 4 of the treatment. Twelve-week therapy resulted in significant decrease in BP clin., (Delta=-28,9 +/- 11,0/-18,4 +/- 8,1; p < 0,001) and HR (Delta=-6,0 +/- 6,6; p < 0,0001). Target SBP, DBP or SBP+DBP levels were achieved in 82%, 96%, and 80%, respectively. In DM-2 patients, target BP level was achieved in 71%. According to 24-hour BP monitoring data, after 12 weeks of treatment, BP was normalized in 68 participants: in 88% - for SBP, in 99% - for DBP, and in 88% - for both SBP and DBP. In all patients, the treatment was well tolerated; adverse effects (A-E) were registered in 9 individuals only. Conclusion. Good antihypertensive effectiveness of fixed trandolapril and verapamil combination facilitated target BP level achievement in 80% of the patients, with low AE rates. Therefore, the medication could be recommended at initial treatment stage

Pharmacoepidemiological aspects of antibacterial therapy of salpingoophoritis in hospital settings

The purpose of the study is an analysis of the consumption of antibacterial drugs in the therapy of salpingoophoritis in hospital settings and evaluation of changes in the real clinical practice of antibiotic therapy after the introduction of the "Order of medical care for the profile "obstetrics and gynecology⋯". Materials and methods. In a retrospective study, an assessment was made of the prescriptions of antibacterial drugs in the therapy of salpingoophritis in specialized treatment and prophylactic institutions of the city of Tomsk in the period 2010-2014. The analysis included 160 case histories. The structure of prescriptions was evaluated on the basis of the application of anatomical-therapeutic-chemical classification and international non-proprietary names (INN), the structural improvement factor K. Gatev was calculated. To quantify the consumption of medications, the calculated daily dose (PDD) was used. Results. Comparative analysis of antibacterial therapy of salpingoophoritis in hospital before and after the introduction of the "Order of medical care for the profile of "obstetrics and gynecology⋯". Leading groups of antibacterial drugs were identified. A comparative analysis of the frequency of assignment of various INN was made. The K. Gate's coefficient was 0.281. The calculation of the average prescribed daily doses of antibacterial drugs was performed. Conclusion. The review of the consumption of antibacterial drugs for salpingoophoritis therapy in hospital settings before and after the introduction of the "Order of medical care for the profile "obstetrics and gynecology⋯", showed that the range of antibacterial drugs used increased from 18 to 24 INN, mainly due to the inclusion of modern medicines. In the structure of appointments in 2013-2014, the proportion of drugs not recommended for use by the «Order of medical care» for the profile of «obstetrics and gynecology» was 37.5%. It was found that PDD clarithromycin, clindamycin and cefotaxime did not meet the recommended dosing regimens specified in the clinical recommendations for antibiotic therapy. The gap between actual clinical practice and existing clinical recommendations determines the need for in-depth pharmacoepidemiological evaluation to identify the causes and develop measures of an organizational and educational nature to optimize the use of medications. © 2018 Siberian State Medical University. All rights reserved