Dependent coordinates in path integral measure factorization

The transformation of the path integral measure under the reduction procedure in the dynamical systems with a symmetry is considered. The investigation is carried out in the case of the Wiener--type path integrals that are used for description of the diffusion on a smooth compact Riemannian manifold with the given free isometric action of the compact semisimple unimodular Lie group. The transformation of the path integral, which factorizes the path integral measure, is based on the application of the optimal nonlinear filtering equation from the stochastic theory. The integral relation between the kernels of the original and reduced semigroup are obtained.Comment: LaTeX2e, 28 page

Использование количественного определения HBsAg для прогноза течения хронического гепатита В у женщин во время беременности и после родов

This study is based on the investigation of 31 HB V-infected women, which have observed at Botkin Infectious Hospital in 2012. Considerable variations of viral load in the course of pregnancy have been observed in the HB V cohort. In the course of pregnancy the HBsAg level does not vary too much. A high HBsAg HBsAg HBsAg HBsAg HBsAg level in the HB HB V cohort can be used as a predictive factor of exacerbation after delivery.статье представлены результаты обследования беременных с хроническим вирусным гепатитом В, наблюдавшихся в поликлиническом отделении Клинической инфекционной больницы им. С.П. Боткина в 2012 г. В результате проведенного исследования было показано, что во время беременности у женщин с ХГВ могут отмечаться значительные колебания вирусной нагрузки, как в сторону увеличения, так и в сторону уменьшения. Было показано, что количество HBsAg HBsAgHBsAgHBsAgявляется более стабильным показателем, чем вирусная нагрузка. Во время беременности редко отмечаются существенные колебания уровня HBsAg. Отмечена зависимость частоты возникновения обострений ХГВ после родов в зависимости от уровня HBsAg . У женщин с высоким уровнем HBsAg частота обострений ХГВ после родов достоверно выше, чем у женщин с низким уровнем HBsAg

Search for Common Molecular Genetic Markers of Nosocomial Pneumonia and Acute Respiratory Distress Syndrome

Genetic predisposition partially accounts for the clinical variability of the course of an infectious process. A total of 750 people, including 419 (81.1%) male patients aged 42.9±0.9 years, admitted to the clinics of the V. A. Negovsky Research Institute of General Reanimatology (Moscow, Russia), were genotyped to establish the influence of genetic factors on their susceptibility to critical conditions.Materials and methods. Tetra-primer allele-specific polymerase chain reaction was used to investigate single-nucleotide polymorphisms (SNP) in the xenobiotic detoxification and oxidative stress genes (CYP1A1 (three sites), AhR, ABCB1, SOD2, GCLC and CAT) and in the vascular homeostasis genes (ACE, AGT, AGTR1, NOS3, VEGFα and MTHFR).Results. A total of 268 nosocomial pneumonia (NP) cases were registered in a patient group. Individual SNP analysis has shown that among the patients with NP the risk of acute respiratory distress syndrome (ARDS) is associated with the carriage of the following genotypes: CYP1A1 rs2606345-Т/Т (p=0.0027, OR=2.38; 95% CI: 1.35—4.17) and AhRrs2066853-G/A-A/A (p=0.0012, OR=2.94; 95% CI: 1.54—5.60). The frequency of the C allele of the AGTR1 gene (re5186) was much higher among the survivors (in the NP group). The assessment of a multiplicative genetic model of genes that had demonstrated the highest single-locus effects because of a ARDS risk, as well as in-hospital mortality, could establish the complex genotype including a combination of risky alleles of the detoxi- fication and vascular homeostasis genes (CYP1A1 rs2606345-T — AhR rs2066853-A and ACE rs4340-D — AGT rs699-C — AGTR1 rs5186-C), which was associated with the increased risk of both NP and ARDS, as well as with the likelihood of a fatal outcome.Conclusion. An understanding of the risk factors of NP and ARDS will aid in predicting the outcome of the underlying disease and in developing possible preventive measures