Turbulence-chemistry interaction in lean premixed hydrogen combustion

This paper presents three-dimensional direct numerical simulations of lean premixed hydrogen flames at an equivalence ratio of varphi=0.4 over a range of turbulence levels from Ka=1 - 36. The simulations form part of a larger effort to construct a DNS database that can be used by the community for model construction and validation. We have focussed on producing well-resolved simulations at conditions representative of atmospheric laboratory-scale flames. After an overview of phenomenological trends with increasing Karlovitz number, we examine the factors that lead to an observed decorrelation between fuel consumption and heat release in the flame at Ka=36. We show that in this flame the fuel consumption is greatly enhanced in regions of positive curvature. We also show that the radical pool is enriched throughout the entire flame as \Ka is increased. In particular, we identify three reactions that, driven by high molar concentrations of radicals at low temperatures, are responsible for high levels of heat release away from regions of fuel consumption, thereby accounting for the observed decorrelation between fuel consumption and heat release

The Bacterial Quality of Lake Waters at Yellowknife, Northwest Territories

A study was conducted to measure the degree of contamination of lake waters at Yellowknife produced by the disposal of domestic wastes, and to assess the suitability of these waters for domestic use. None of the samples analyzed met Canadian standards for drinking water. Though the bacterial quality of the main body of water was found to be good, there was contamination at points of discharge of sewage and near storm drains, marsh muds and sediments. It is recommended that the City of Yellowknife seek an alternative site for sewage disposal and give adequate publicity to the dangers of using inadequately treated water

Physical Logic

In R.D. Sorkin's framework for logic in physics a clear separation is made between the collection of unasserted propositions about the physical world and the affirmation or denial of these propositions by the physical world. The unasserted propositions form a Boolean algebra because they correspond to subsets of an underlying set of spacetime histories. Physical rules of inference, apply not to the propositions in themselves but to the affirmation and denial of these propositions by the actual world. This physical logic may or may not respect the propositions' underlying Boolean structure. We prove that this logic is Boolean if and only if the following three axioms hold: (i) The world is affirmed, (ii) Modus Ponens and (iii) If a proposition is denied then its negation, or complement, is affirmed. When a physical system is governed by a dynamical law in the form of a quantum measure with the rule that events of zero measure are denied, the axioms (i) - (iii) prove to be too rigid and need to be modified. One promising scheme for quantum mechanics as quantum measure theory corresponds to replacing axiom (iii) with axiom (iv) Nature is as fine grained as the dynamics allows.Comment: 14 pages, v2 published version with a change in the title and other minor change

Maturity Onset Diabetes of the Young (MODY)

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147788/1/dme199613s690.pd

Purification and characterization of yeast orotidine 5'-monophosphate decarboxylase overexpressed from plasmid PGU2

Orotidine 5'-monophosphate decarboxylase (ODCase) has been overexpressed in yeast 15C cells transformed with a plasmid carrying the URA3 gene that encodes ODCase. Twenty g of cells having ODCase activity equal to 30 mg of pure enzyme per liter of cell culture were obtained after 9 h of galactose induction. To remove yeast proteases, a 60-90% ammonium sulfate fractionation step plus the addition of EDTA as an inhibitor of metallopeptidases was necessary. The purification protocol yielded ODCase that was protease-free and stable to storage at 4 degrees C for 16 months. The pure enzyme had a specific activity of 40 units/mg in 50 mM phosphate buffer, pH 6, and could be stored at -20 degrees C in 20% glycerol with retention of full activity for more than 2 years. The enzyme had a Km for orotidine 5'-monophosphate of 0.7 microM at pH 6 and 25 degrees C. The molecular weight of the plasmid-derived ODCase monomer determined by electrophoresis on denaturing polyacrylamide gels was 29,500. ODCase sedimented through sucrose density gradients as a monomer of about 30 kDa at low protein concentration and in the absence of ligands that bind at the catalytic site. An increase in the sedimentation rate could be induced by increasing the ODCase concentration or by adding ligands that are competitive inhibitors. ODCase sedimented in a single band typical of a protein of 46 kDa at the highest protein concentration studied or in the presence of 50 mM phosphate or 933 microM substrate (orotidine 5'-monophosphate) or product (UMP). A dimer sedimenting as a protein of about 64 kDa occurred in the presence of 50 microM 6-azauridine 5'-monophosphate or 2 microM 1-(5'-phospho-beta-D-ribofuranosyl) barbituric acid, competitive inhibitors of ODCase. These results resemble the ligand-induced subunit association of the ODCase domain of bifunctional UMP synthase and support the use of yeast ODCase as a model for ODCases from other species

Frost weathering of chalk

The processes and factors that determine the heave and fracture of frost-susceptible bedrock exposed to temperature cycling above and below 0°C are little known but important to understanding of rock deformation, weathering and ground conditions. To investigate the early stages of heave, settlement and fracture of intact chalk, physical modelling experiments were performed on blocks of Saint Cyr Tuffeau and Totternhoe Clunch. Unidirectional (downward) freezing simulated seasonally frozen bedrock in non-permafrost regions, and bidirectional (upward from permafrost and downward from the surface) simulated an active layer above permafrost. Heave and settlement of the top of the blocks were monitored in relation to rock temperature and unfrozen water content. Heave and settlement showed complex behavior that varied with moisture content, freezing regime and time. Progressive heave of wet chalk during thaw periods (simulated summers) is attributed to microcracking in near-surface permafrost. Macrocracking was favoured near the rock top during unidirectional freezing and near the permafrost table during bidirectional freezing, producing extensive fracture networks. Four processes, operating singly or in combination, account for the heave and settlement behavior: (1) thermal expansion and contraction in dry chalk; (2) volumetric expansion of freezing water, causing bursts of heave; (3) ice segregation, causing sustained heave and rock fracture; and (4) freeze‒thaw cycling, causing initial consolidation and settling of wet chalk during unidirectional freezing. The experimental data and field observations of chalk weathering profiles elucidate the nature and origin of chalk brecciation. Type 1 brecciation (angular or subangular rock fragments separated by unfilled fractures with matched sides) is attributed primarily to ice segregation. Type 2 brecciation (subangular to rounded lumps of rock—lithorelicts—set in a fine-grained matrix of the same, but softer and remoulded material) probably resulted from frost weathering and limited ground movement, particularly beneath the sides and bottoms of wet (now dry) valleys

Gamma-ray emission expected from Kepler's SNR

Nonlinear kinetic theory of cosmic ray (CR) acceleration in supernova remnants (SNRs) is used to investigate the properties of Kepler's SNR and, in particular, to predict the gamma-ray spectrum expected from this SNR. Observations of the nonthermal radio and X-ray emission spectra as well as theoretical constraints for the total supernova (SN) explosion energy E_sn are used to constrain the astronomical and particle acceleration parameters of the system. Under the assumption that Kepler's SN is a type Ia SN we determine for any given explosion energy E_sn and source distance d the mass density of the ambient interstellar medium (ISM) from a fit to the observed SNR size and expansion speed. This makes it possible to make predictions for the expected gamma-ray flux. Exploring the expected distance range we find that for a typical explosion energy E_sn=10^51 erg the expected energy flux of TeV gamma-rays varies from 2x10^{-11} to 10^{-13} erg/(cm^2 s) when the distance changes from d=3.4 kpc to 7 kpc. In all cases the gamma-ray emission is dominated by \pi^0-decay gamma-rays due to nuclear CRs. Therefore Kepler's SNR represents a very promising target for instruments like H.E.S.S., CANGAROO and GLAST. A non-detection of gamma-rays would mean that the actual source distance is larger than 7 kpc.Comment: 6 pages, 4 figures. Accepted for publication in Astronomy and Astrophysics, minor typos correcte

Stability of π\pi junction configurations in ferromagnet-superconductor heterostructures

We investigate the stability of possible order parameter configurations in clean layered heterostructures of the $SFS...FS$ type, where $S$ is a superconductor and $F$ a ferromagnet. We find that for most reasonable values of the geometric parameters (layer thicknesses and number) and of the material parameters (such as magnetic polarization, wavevector mismatch, and oxide barrier strength) several solutions of the {\it self consistent} microscopic equations can coexist, which differ in the arrangement of the sequence of ``0'' and ``$\pi$'' junction types (that is, with either same or opposite sign of the pair potential in adjacent $S$ layers). The number of such coexisting self consistent solutions increases with the number of layers. Studying the relative stability of these configurations requires an accurate computation of the small difference in the condensation free energies of these inhomogeneous systems. We perform these calculations, starting with numerical self consistent solutions of the Bogoliubov-de Gennes equations. We present extensive results for the condensation free energies of the different possible configurations, obtained by using efficient and accurate numerical methods, and discuss their relative stabilities. Results for the experimentally measurable density of states are also given for different configurations and clear differences in the spectra are revealed. Comprehensive and systematic results as a function of the relevant parameters for systems consisting of three and seven layers (one or three junctions) are given, and the generalization to larger number of layers is discussed.Comment: 17 pages, including 14 Figures. Higher resolution figures available from the author

Relational Hidden Variables and Non-Locality

We use a simple relational framework to develop the key notions and results on hidden variables and non-locality. The extensive literature on these topics in the foundations of quantum mechanics is couched in terms of probabilistic models, and properties such as locality and no-signalling are formulated probabilistically. We show that to a remarkable extent, the main structure of the theory, through the major No-Go theorems and beyond, survives intact under the replacement of probability distributions by mere relations.Comment: 42 pages in journal style. To appear in Studia Logic