Overparameterised controllers can reduce non-singular costs

By means of two examples we show that non-singular costs can been reduced for adaptive controllers by overparameterising the estimators. The examples are for scalar and second order systems respectively. In the second example the tuning function design and the overparameterised adaptive backstepping design are compared. In both cases a system is constructed for which the overparameterised design is superior w.r.t. a non-singular measure of transient performance

Deliberations of the Safety Task Force:Risk factors and treatment of adverse events associated with aesthetic injectables

BackgroundThe growing popularity of aesthetic procedures involving fillers, biostimulators, and neurotoxins has prompted concerns about patient safety. To address these concerns, a global Safety Task Force (STF) was formed.AimsThe inaugural STF meeting prioritized vascular compromise prevention and management, guiding clinical trial design and materials for future meetings, and collecting data from experts on current safety methods.MethodsThe STF was formed and consisted of 16 experts from nine different countries, with each possessing distinct expertise in various fields related to aesthetic injectables. Current safety data, protocols, knowledge gaps and future research priorities were discussed and voted upon.ResultsThe establishment of a global database for tracking filler-related AEs was favored by 93% of participants. Discussions revolved around the database's scope, data standardization, and whether non-medical contributors should be included. Aspiration as a safety technique garnered support from 73% of participants. Approximately 43% of participants incorporate ultrasound in their injections, with divergent opinions on its impact and potential when used as a standard of practice versus in AE management. Most physicians on the task force incorporated cannula use for some of their injections (93%). There were varying perspectives on treatments for vascular adverse events (VAE), the primary causes, and the adoption of new protocols in the field.ConclusionsThe STF meeting underscored the need for a coordinated effort to address complications related to HA fillers, including VAE management and hyaluronidase protocols. Reliable treatment endpoints were evaluated, but improved measurement methods are needed. Future meetings will focus on addressing delayed complications, furthering safety in this field

The structure of cluster merger shocks: turbulent width and the electron heating time-scale

We present a new 2 Ms Chandra observation of the cluster merger Abell 2146, which hosts two huge M∼2 shock fronts each ∼500 kpc across. For the first time, we resolve and measure the width of cluster merger shocks. The best-fit width for the bow shock is 17 ± 1 kpc and for the upstream shock is 10.7 ± 0.3 kpc. A narrow collisionless shock will appear broader in projection if its smooth shape is warped by local gas motions. We show that both shock widths are consistent with collisionless shocks blurred by local gas motions of 290 ± 30 km s −1. The upstream shock forms later on in the merger than the bow shock and is therefore expected to be significantly narrower. From the electron temperature profile behind the bow shock, we measure the timescale for the electrons and ions to come back into thermal equilibrium. We rule out rapid thermal equilibration of the electrons with the shock-heated ions at the 6σ level. The observed temperature profile instead favours collisional equilibration. We find no evidence for electron heating over that produced by adiabatic compression. This supports the existing picture from collisionless shocks in the solar wind and supernova remnants. The upstream shock is consistent with this result but has a more complex structure, including a ∼ 2 keV increase in temperature ∼50 kpc ahead of the shock

Main goals and obtained results of the THERMINIC Project

International audienceTherminic (Thermal Investigation of ICs) is a Copernicus project, supported by the EU for the 1995-98 period. The main goals of the project are: development of innovative temperature sensors, checking the feasibility of on-line thermal monitoring, comparison of the temperature-field measurement and simulation methods of ICs, thermal model identification of the packages based on the measuring of thermal transients. The paper presents the achieved results at the two-thirds time of the project

Detection of linear IgE deposits in bullous pemphigoid and mucous membrane pemphigoid: a useful clue for diagnosis

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease of the skin associated with IgG autoantibodies to BP180 and BP230, while mucous membrane pemphigoid (MMP) comprises a heterogeneous group of autoimmune blistering diseases characterized by a predominant mucous membrane involvement and scarring tendency associated with an autoantibody response to various autoantigens, including BP180. While the pathogenicity of IgG autoantibodies to BP180 has been demonstrated in BP, the role of IgE autoantibodies in mediating tissue damage in BP and MMP is unclear

Self-reactivity in the dimeric intravenous immunoglobulin fraction

Therapeutic intravenous immunoglobulin (IVIg) preparations contain antibodies reflecting the cumulative antigen experience of the donor population. IVIg contains variable amounts of monomeric and dimeric IgG, but there is little information available on their comparative antibody specificities. We have isolated highly purified fractions of monomeric and dimeric IgG by size-exclusion chromatography. Following treatment of all fractions at pH4, analyses by immunodot and immunocytology on human cell lines showed a preferential recognition of autoantigens in the dimeric IgG fraction. Investigation of the HEp-2 cytoplasmic proteome by 2D-PAGE, Western blot, and subsequent identification of IVIg reactive spots by mass spectrometry (LC-MS/MS) showed that IVIg recognized only a restricted set of the total proteins. Similar experiments showed that more antigens were recognized by the dimeric IgG fraction, especially when the dissociated dimer fraction was used, as compared to its monomeric counterpart. These observations are consistent with idiotype-anti-idiotype masking of auto-specific Abs in the dimeric fraction of IVIg