3 research outputs found
Adaptation and psychometric testing of the Turkish evaluation of daily activity questionnaire in people with rheumatoid arthritis
Purpose: The aims were to translate the Evaluation of Daily Activity Questionnaire (EDAQ) into Turkish, then test validity and reliability in people with rheumatoid arthritis (RA) in Turkey. Material and Methods: Phase 1: The EDAQ was forward and backward translated, culturally adapted following cognitive debriefing interviews with participants with RA (n=10) and finalised by an expert committee. Phase 2: Participants (n=215) completed a questionnaire including the EDAQ, Health Assessment Questionnaire (HAQ), and Short-Form 36 v1 (SF-36v1). Two weeks later, the EDAQ was again completed for test-retest reliability (n=82:38%). Internal construct validity was assessed using Rasch analysis. Internal consistency, concurrent validity, and test-retest reliability were assessed. Results: Following cultural adaptation, one item was removed, and examples increased or changed. Cronbach’s α values were 0.71 – 0.93 for all EDAQ domains, i.e., acceptable to good. The EDAQ met Rasch model requirements for fit (excellent construct validity: p>0.05). Concurrent validity was moderate to strong for most EDAQ domains with HAQ (rs 0.49-0.81) and SF-36-v1 Physical Function (rs 0.42-0.70). There was excellent test-retest reliability for all domains (ICC (2,1): 0.95-1.00).Conclusion: The Turkish EDAQ is a valid, reliable measure of daily activity ability for use in practice and research with Turkish speakers with RA
The Effect of Hydrogen Sulphide on Experimental Cerebral Vasospasm.
Cerebral vasospasm is the primary cause of morbidity and mortality after subarachnoid hemorrhage (SAH). Hydrogen Sulfide (H 2 S), a gaseous neurotransmitter, is produced in many tissues including the central nervous system (CNS). The vasodilatatory effect of H2S has been shown in the CNS; however, its role in cerebral vasospasm has not been investigated before
The Effect of Hydrogen Sulphide on Experimental Cerebral Vasospasm
AIM: Cerebral vasospasm is the primary cause of morbidity and mortality
after subarachnoid hemorrhage (SAH). Hydrogen Sulfide (H2S), a gaseous
neurotransmitter, is produced in many tissues including the central
nervous system (CNS). The vasodilatatory effect of H2S has been shown in
the CNS; however, its role in cerebral vasospasm has not been
investigated before.
MATERIAL and METHODS: The rats were divided into 8 groups: control, SAH,
sodium hydrosulphide (NaHS), propargylglycine (PPG), aminooxy acetic
acid (AOAA), SAH+NaHS, SAH+PPG, and SAH+AOAA. After establishing
experimental SAH, the basilar artery and brain stem were harvested at
24th hours. The diameter and wall thickness of basilar artery were
measured. Production of H2S was assessed by showing the activity of
cystathionine beta-synthase (CBS) and cystathionine gamma-lyase enzymes
(CSE).
RESULTS: NaHS treatment significantly reduced vasospasm at 24 hours
following SAH. This vasodilatatory effect was correlated with the CSE
expression in basilar artery. CSE and CBS enzyme expressions were
significantly lower in brain stem and basilar artery in PPG and
AOAA-treated groups. PPG and AOAA treatments exerted a vasoconstrictive
effect in the basilar artery. There were statistically significant
differences between NaHS, PPG and AOAA groups, in terms of basilar
artery lumina! diameter.
CONCLUSION: H2S may have a therapeutic potential in the treatment of
vasospasm with its vasodilatator activity