Identification of the first surrogate agonists for the G protein-coupled receptor GPR132

We report the first pharmacological tool agonist for in vitro characterization of the orphan receptor GPR132, preliminary structure–activity relationships based on 32 analogs and a suggested binding mode from docking.M.A.S. was supported by a research scholarship from the Drug Research Academy and Novo Nordisk A/S. D.E.G. and H.B.-O. gratefully acknowledge financial support by the Carlsberg Foundation. D.E.G. and D.S.P. gratefully acknowledges financial support by the Lundbeck Foundation. Nils Nyberg is acknowledged for help with NMR spectroscopy. NMR equipment used in this work was purchased via a grant from The Lundbeck Foundation (R77-A6742).This is the accepted manuscript. The final version is available at http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/c5ra04804d#!divAbstract

Measurement of charm production at central rapidity in proton-proton collisions at square s = 2.76 TeV

The p(t)-differential production cross sections of the prompt (B feed-down subtracted) charmed mesons D-0, D+, and D*(+) in the rapidity range vertical bar y vertical bar < 0.5, and for transverse momentum 1 < p(t) < 12 GeV/c, were measured in proton-proton collisions at root s = 2.76 TeV with the ALICE detector at the Large Hadron Collider. The analysis exploited the hadronic decays D-0 -> K-pi(+), D+ -> K-pi(+)pi(+), D*(+) -> D-0 pi(+), and their charge conjugates, and was performed on a L-int = 1.1 nb(-1) event sample collected in 2011 with a minimum-bias trigger. The total charm production cross section at root s = 2.76 TeV and our previous measurements at root s = 7 TeV. The results were compared to existing measurements and to perturbative-QCD calculations. The fraction of c(d)over-bar D mesons produced in a vector state was also determined