Plangebied fietsverbinding Uitgeesterweg - Zeeweg te Limmen, gemeente Castricum

Coordinaten:107.784/508.388 Datum einde onderzoek:feb. 2008 Projectmedewerkers:C. Soonius, D. Bekius, R. Timmerman Complextype(n):xxx Datering:xxx Diversen: Soonius, C. en D. Bekius, Plangebied fietsverbinding Uitgeesterweg - Zeeweg te Limmen, gemeente Castricum; archeologisch vooronderzoek: een inventariserend veldonderzoek (karterende fase), RAAPnotitie 2604 (WEESP, 2008

Neuromuscular control before and after independent walking onset in children with cerebral palsy

Early brain lesions which produce cerebral palsy (CP) may affect the development of walking. It is unclear whether or how neuromuscular control, as evaluated by muscle synergy analysis, differs in young children with CP compared to typically developing (TD) children with the same walking ability, before and after the onset of independent walking. Here we grouped twenty children with (high risk of) CP and twenty TD children (age 6.5–52.4 months) based on their walking ability, supported or independent walking. Muscle synergies were extracted from electromyography data of bilateral leg muscles using non-negative matrix factorization. Number, synergies’ structure and variability accounted for when extracting one (VAF1 ) or two (VAF2 ) synergies were compared between CP and TD. Children in the CP group recruited fewer synergies with higher VAF1 and VAF2 compared to TD children in the supported and independent walking group. The most affected side in children with asymmetric CP walking independently recruited fewer synergies with higher VAF1 compared to the least affected side. Our findings suggest that early brain lesions result in early alterations of neuromuscular control, specific for the most affected side in asymmetric CP.Biomechatronics & Human-Machine Contro

Management and Good Laboratory Practice Central Animal Facility

This report describes the realisation and implementation of working procedures in compliance with Good Laboratory Practice, as performed by the Central Animal Facility of Division II Pharmacology and Toxicology. This report froms a basis for a quality system with the pivot aim to meet Sterlab requirements.RIV

Management and Good Laboratory Practice at the Division Biological Evaluation of Drug effects of the Central Animal Laboratory

The department BES (Biological Evaluation of Drug Effects) carries out animal studies for RIVM laboratories, whose commitment to GLP makes it necessary for BES also to comply with GLP. Compliance is assured by means of a quality system laid down in a quality handbook quaranteeing the consistent quality of the department products. The elements of the BES quality system are documented in this report under the following headings: - quality targets and management organisation - survey of areas of competence and of stoff qualifications - equipment inventory - goods and services available - standard operating procedures. Furthermore a general servey is presented of those co-operative arrangements necessary for optimal departmental organization.RIV