The Effect Of Telithromycin On Inflammatory Markers In Chronic Obstructive Pulmonary Diseases

Aim : To evaluate the anti-inflammatory effect of telithromycin on sputum interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) levels in patient with chronic obstructive pulmonary diseases (COPD). Methods : Thirty four patients with mild to moderate COPD were enrolled in this prospective, single center, double-blind, placebo controlled study. Subjects received either telithromycin or placebo for 10 days. Before and after treatment period spirometric tests, arterial blood gas analyses were performed, sputum samples were taken for measurement of sputum inflammatory markers, and spu-tum was induced. Results : There was no statistical difference in baseline clinical or laboratory parameters between groups. After the treatment, the induced sputum IL-8, TNF-α, , MPO levels is similar compared with pretreatment levels. Conclusion : In this study, anti-inflammatory effects of telithro-mycin in stable COPD patients were not demonstrated. Further studies are needed to determine the clinical significance of these findings

Bir Anterior Mediastinal Primer Miksoid Liposarkoma Olgusu

WOS:000361630600012Liposarkomalar (LPS) mezenkimal neoplazmalar arasında tüm sarkomların yaklaşık olarak %15'ini ve primer mediastinal tümörlerinde %6'sını oluşturmaktadırlar. Liposarkomalar genellikle alt extremite ve retroperitoneumda bulunurlar, ayrıca abdomen, vulva ve kalça bölgesinde de raporlanmıştır. Bununla birlikte anterior medi- astende primer liposarkom vakaları oldukça seyrek olarak karşımıza çıkmaktadır. Biz buradaki mevcut makalemizde anterior mediastende yerleşmiş hızla ilerleyen ve metastazlarla seyreden primer miksoid liposarkoma olgusunu sunduk.Liposarcomas (LPS) account for approximately 15% of all sarcomas among mesenchymal neoplasms and 6% of primary mediastinal tumors. LPS, usually found in the lower extremities or retroperitoneum, have also been reported in the abdomen, vulva, and buttocks. However, primary LPS of the anterior mediastinum are extremely rare. In this paper, we present a case of a fast progressing metastatic primary myxoid liposarcoma of the anterior mediastinu

An Anterior Primary Myxoid Liposarcoma Case

Liposarcomas (LPS) account for approximately 15% of all sarcomas among mesenchymal neoplasms and 6% of primary mediastinal tumors. LPS, usually found in the lower extremities or retroperitoneum, have also been reported in the abdomen, vulva, and buttocks. However, primary LPS of the anterior mediastinum are extremely rare. In this paper, we present a case of a fast progressing metastatic primary myxoid liposarcoma of the anterior mediastinum

Homocysteine levels in patients with masked hypertension

WOS:000338109400011PubMed ID: 24818625Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure >140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with masked hyper- tension. Patients with high blood pressure showed higher homocysteine levels when compared to masked hypertension (p0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r0.335, p0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with masked hypertension, homocysteine levels may not have any significant effect upon high blood pressure levels

Original Investigation 357 Homocysteine levels in patients with masked hypertension

Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with masked hypertension. Patients with high blood pressure showed higher homocysteine levels when compared to masked hypertension (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with masked hypertension, homocystein