5 research outputs found
Screening study on significant Chinese herb for anti-idiopathic pulmonary fibrosis by combining clinical experience prescriptions and molecular dynamics simulation technologies
Various techniques such as data mining, network pharmacology, molecular docking and molecular dynamics simulation were used in this study to screen and validate effective herbal medicines for the treatment of idiopathic pulmonary fibrosis (IPF) and to reveal their mechanisms of action at the molecular level. The use of this approach will provide new tools and ideas for future drug screening, especially for the application of herbal medicines in the treatment of complex diseases. Among them, the five identified core targets, including IL6, TP53, AKT1, VEGFA, and TNF, as well as a series of major active compounds, will be important references for future anti-IPF drug development. This information will accelerate the discovery and development of relevant drugs. Meanwhile, this study further confirmed the potential value of four Chinese herbal medicines, including Gancao, Danshen, Huangqin, and Sanqi, in the treatment of IPF. This will promote more clinical trials and practices to confirm and optimise the application of these herbs. Finally, this study is an important theoretical guide to enhance the advantages of Chinese herbal medicines in the prevention and treatment of major and difficult diseases, as well as to understand and utilise the potential efficacy of Chinese herbal medicines. This will further promote the scientific research and clinical application of herbal medicines and provide more possibilities for future disease treatment Communicated by Ramaswamy H. Sarma</p
Synthesis of D-Sorbose and D-Psicose by Recombinant <i>Escherichia coli</i>
<div><p>GRAPHICAL ABSTRACT</p><p></p></div
Atomistic Insights into Medium-Entropy Perovskites for Efficient and Robust CO<sub>2</sub> Electrolysis
Solid oxide electrolysis cells (SOECs) show great promise
in converting
CO2 to valuable products. However, their practicality for
the CO2 reduction reaction (CO2RR) is restricted
by sluggish kinetics and limited durability. Herein, we propose a
novel medium-entropy perovskite, Sr2(Fe1.0Ti0.25Cr0.25Mn0.25Mo0.25)O6âδ (SFTCMM), as a potential electrode material
for symmetrical SOEC toward CO2RR. Experimental and theoretical
results unveil that the configuration entropy of SFTCMM perovskites
contributes to the strengthened metal 3dâO 2p hybridization
and the reduced O 2p bond center. This variation of electronic structure
benefits oxygen vacancy creation and diffusion as well as CO2 adsorption and activation and ultimately accelerates CO2RR and oxygen electrocatalysis kinetics. Notably, the SFTCMM-based
symmetrical SOEC delivers an excellent current density of 1.50 A cmâ2 at 800 °C and 1.5 V, surpassing the prototype
Sr2Fe1.5Mo0.5O6âδ (SFM, 1.04 A cmâ2) and most of the state-of-the-art
electrodes for symmetrical SOECs. Moreover, the SFTCMM-based symmetrical
SOEC demonstrates stable CO2RR operation for 160 h
Data_Sheet_1_Physiological and transcriptome analyses reveal the photosynthetic response to drought stress in drought-sensitive (Fengjiao) and drought-tolerant (Hanjiao) Zanthoxylum bungeanum cultivars.xlsx
As an important economical plant, Zanthoxylum bungeanum is widely cultivated in arid and semi-arid areas. The studies associated with photosynthesis under drought stress were widely carried out, but not yet in Z. bungeanum. Here, the photosynthesis of two Z. bungeanum cultivars (FJ, Z. bungeanum cv. âFengjiaoâ; HJ, Z. bungeanum cv. âHanjiaoâ) was analyzed under drought stress using physiological indicators and transcriptome data. Drought decreased stomatal aperture and stomatal conductance (Gsw), reduced transpiration rate (E) and sub-stomatal CO2 concentration (Ci), and lowered chlorophyll and carotenoid content, which reduced the net photosynthetic rate (Pn) of Z. bungeanum. The higher photosynthetic rate in HJ stemmed from its higher chlorophyll content, larger stomatal aperture and Gsw, and higher Ci. Weighted gene co-expression network analysis (WGCNA) identified several ABA signal transduction genes (PYL4, PYL9, and PYR1), LCH-encoding genes (LHCB4.3), and chlorophyll metabolism genes (CRD1, PORA, and CHLH). Additionally, seven transcription factor genes were identified as important factors regulating photosynthesis under drought conditions. In general, a photosynthetic response model under drought stress was built firstly in Z. bungeanum, and the key genes involved in photosynthesis under drought stress were identified. Therefore, the results in our research provide important information for photosynthesis under drought and provided key clues for future molecular breeding in Z. bungeanum.</p
Data_Sheet_2_Physiological and transcriptome analyses reveal the photosynthetic response to drought stress in drought-sensitive (Fengjiao) and drought-tolerant (Hanjiao) Zanthoxylum bungeanum cultivars.pdf
As an important economical plant, Zanthoxylum bungeanum is widely cultivated in arid and semi-arid areas. The studies associated with photosynthesis under drought stress were widely carried out, but not yet in Z. bungeanum. Here, the photosynthesis of two Z. bungeanum cultivars (FJ, Z. bungeanum cv. âFengjiaoâ; HJ, Z. bungeanum cv. âHanjiaoâ) was analyzed under drought stress using physiological indicators and transcriptome data. Drought decreased stomatal aperture and stomatal conductance (Gsw), reduced transpiration rate (E) and sub-stomatal CO2 concentration (Ci), and lowered chlorophyll and carotenoid content, which reduced the net photosynthetic rate (Pn) of Z. bungeanum. The higher photosynthetic rate in HJ stemmed from its higher chlorophyll content, larger stomatal aperture and Gsw, and higher Ci. Weighted gene co-expression network analysis (WGCNA) identified several ABA signal transduction genes (PYL4, PYL9, and PYR1), LCH-encoding genes (LHCB4.3), and chlorophyll metabolism genes (CRD1, PORA, and CHLH). Additionally, seven transcription factor genes were identified as important factors regulating photosynthesis under drought conditions. In general, a photosynthetic response model under drought stress was built firstly in Z. bungeanum, and the key genes involved in photosynthesis under drought stress were identified. Therefore, the results in our research provide important information for photosynthesis under drought and provided key clues for future molecular breeding in Z. bungeanum.</p