The Detection of the Stock Price Manipulation by Hybrid Genetic Algorithm: Artificial Neural Network Model (ANN-GA) and SQDF Model

The purpose of this research is to detect manipulation of stock prices in Tehran Stock Exchange that it has been done through Hybrid Genetic Algorithm-artificial neural network (ANN-GA) model and the Simplified Quadratic Discriminant Function (SQDF) Model. In this study, the variables of price, trading volume and free float stock to match the results of the model and the actual data of price manipulation is used. In the Hybrid Model of Genetic Algorithm-Artificial Neural Networks (ANN-GA), at first data of 316 stock companies from 2009/03/21 to 2013/03/20 on a daily basis, including 966 days were put into the GA model, then; weight of each variable were derived from GA. Next, using these weights, Perceptron neural network was designed, implemented and its efficiency was approved. Then, SQDF model was designed and implemented and its efficiency was verified. In the end, using MAPE[1], RMSE[2]and R2 error measurement, the results of ANN-GA model were compared with those of SQDF model. The results showed that Hybrid model has much better performance and fewer errors than SQDF model in the detection of stock price manipulation and classifying firms into two groups, manipulate and non-manipulate [1]. Artificial Neural Networks-Genetic Algorithm [2]. Simplified Quadratic Discriminant Functio

Prevalence of hepatitis A among newly admitted medical students of Isfahan city in 2012

زمینه و هدف: دانشجویان علوم پزشکی معمولاً در معرض تماس با عوامل عفونی مثل هپاتیت A می باشد. این مطالعه سرولوژیکی به منظور بررسی فراوانی نسبی هپاتیت A در بین دانشجویان پزشکی در بدو ورود به دانشگاه علوم پزشکی اصفهان در سال 1390 انجام گرفته است. روش بررسی: در این مطالعه مقطعی (توصیفی- تحلیلی) 403 دانشجوی سال اول به روش نمونه گیری غیر احتمالی آسان انتخاب و نمونه سرم آن ها به منظور تعیین آنتی بادی توتال IgG و IgM علیه هپاتیت A با روش الایزا مورد بررسی قرار گرفت. یافته ها: دانشجویان شامل 252 نفر (5/62 درصد) مرد و 151 نفر (5/37 درصد) زن بودند. شیوع آنتی بادی علیه هپاتیت A، 5/67 درصد ارزیابی شد. در این میان ابتلا به هپاتیت A با محل سکونت (01/0P=) و نوع آب آشامیدنی (018/0P=) ارتباط معنی داری نشان داد. نتیجه گیری: با توجه به در معرض خطر بودن دانشجویان پزشکی، غربالگری اولیه و واکسیناسیون افرادی که علیه هپاتیت A مصونیت ندارند، توصیه می شود

Immunoglobulin A Nephropathy and Malaria falciparum Infection; a Rare Association

Glomerular involvement occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Here, we report a rare case of falciparum malaria-associated IgA nephropathy. A 28-year-old man was admitted because of fever and abdominal pain. Ultrasound and computed tomography (CT) showed right kidney pyonenphrosis. Despite placing a nephrostomy tube, fever continued. Repeated CT was in favor of focal pyelonephritis. In addition, peripheral blood smear suggested malaria. Anti-malarial drugs were initiated and right nephrectomy was performed. One year after recovery from malaria, a persistent rise in serum creatinine was detected. A left kidney biopsy showed mesangial proliferation and dominant IgA deposits in immunofluorescence study while C(1)q was not deposited. The impression was IgA nephropathy with M1E0S0T0 of Oxford classification. The patient was prescribed a combination of low dose prednisolone and angiotensin converting enzyme inhibitor. Six months after treatment serum creatinine decreased from 1.6 mg/dL to 1.3mg/dL and urine abnormalities were disappeared. Our findings suggest that malaria infection might be associated with IgA nephropathy

Detection of Legionella pneumophila in the bronchoalveolar lavage samples by real time PCR in patients with ventilator-associated pneumonia in ICU

زمینه و هدف: لژیونلا پنوموفیلا به خاطر توانایی آن در ایجاد پنومونی ناشی از ونتیلاسیون مکانیکی مورد توجه مراکز درمانی است. هدف از این مطالعه ردیابی گونه های لژیونلا پنوموفیلا در نمونه های بدست آمده از برونکوآلوئولار لاواژ با روشReal Time PCR در بیماران بستری در بخش مراقبت های ویژه ی بیمارستان الزهرا(س) اصفهان می باشد. روش بررسی: در یک مطالعه توصیفی تحلیلی سی و نه نمونه برونکوآلوئولار لاواژ در بیماران مبتلا به پنومونی همراه با ونتیلاتور بستری در بخش مراقبت های ویژه (ICU) بیمارستان الزهرای اصفهان در سال 1390 گرفته و تا زمان آزمایش در 20- درجه سانتیگراد نگهداری شد. DNA به روش فنل کلروفرم استخراج و آزمایش Real Time PCR در 45 چرخه شامل oC95 برای 4 ثانیه و oC58 برای 30 ثانیه انجام شد. در حالی که پروب به روش Taq Man عمل می کرد. یافته ها: نتیجه برای حضور باکتری لژیونلا پنوموفیلا در همه نمونه ها منفی شد. حداقل سن افراد در مطالعه 20 و حداکثر 86 سال بوده است. مدت زمان بستری افراد مورد مطالعه در ICU حداقل 2 روز و حداکثر 65 روز است. مدت زمان ونتیلاسیون افراد مورد مطالعه حداقل 2 روز و حداکثر 65 روز بود. نتیجه گیری: این مطالعه عدم حضور لژیونلا پنوموفیلا در بیماران دچار پنومونی وابسته به ونتیلاتور در ICU بیمارستان الزهرای اصفهان رادریک مقطع زمانی نشان می دهد؛ لذا بر اساس مطالعه فوق، شناخت الگوی میکروبیولوژیک لژیونلا پنوموفیلا در سایر مراکز درمانی نیز امری منطقی به نظر می رسد

Statin efficacy in the treatment of hepatitis C genotype I

Background: Lipid metabolism is one of the hepatitis C virus (HCV) life cycle steps. Statins can reduce cholesterol level and finally can decrease HCV replication. Thus, we assessed the effect of Statins in combination with standard antiviral treatment on hyperlipidemic genotype I HCV infected patients. Materials and Methods: This study was a prospective clinical trial. 40 patients were selected from those referred to educational and Therapeutic Centers of Isfahan University of Medical Sciences from 2009 to 2010 with confirmed HCV viremia. All patients received Peg-interferon-a2a and ribavirin. 20 hyperlipidemic Patients received 20 mg atorvastatin nightly for 3 months and placebo was prescribed for 20 normolipidemic HCV infected patients as a control group. Liver enzymes and complete blood count were checked monthly and thyroid stimulating hormone was checked every 3 months. We also performed quantitative HCV-ribonucleic acid (RNA) test in 12th week of therapy, at the end of treatment and 6 months after therapy for all samples. Results: We didn't find any significant differences in the mean of HCV-RNA numbers between statin and placebo groups in 12th week of treatment, in the end of treatment and 6 months after treatment (P > 0.05). Conclusion: Atorvastatin has no effect on the mean of HCV viral load when we added it to standard treatment for hepatitis C infection. Further studies are necessary to examine the possible antiviral properties of statins and their potential role as adjuncts to standard HCV therapy

Prevalence of Transfusion Transmitted Virus Infection in Hemodialysis Patients and Injection Drug Users Compared to Healthy Blood Donors in Isfahan, Iran

Introduction. The pathogenicity and transmission routes of Transfusion Transmitted Virus (TTV) remain unclear. The aim of this study was to determine the prevalence of TTV in hemodialysis patients, injecting drug users (IDUs), and healthy blood donors, in Isfahan, Iran. Method. In a case-control study, a total of 108 subjects were put into three groups namely Group I, 36 hemodialysis patients; Group II, 36 IDUs; and Group III, 36 healthy blood donors as the control group. A 5 ml blood sample was collected from each subject in an EDTA-containing tube. Samples were tested for TTV DNA by means of real-time polymerase chain reaction (PCR). Results. The mean age was years. Seventy-one subjects (66%) were male. Of the108 cases, 30 (27.8%) were TTV positive and 78 (72.2%) were TTV negative. The prevalence of TTV in IDUs [21 (58%)] was significantly higher than in the other groups [group I: 6 (17 %) and group III: 3 (8%)] (). Conclusion. The prevalence of TTV in IDUs is significantly higher than in both hemodialysis patients and general population in Isfahan, Iran. It seems necessary to take serious measures to reduce the risk of TTV transmission to IDUs’ close contacts and health care providers