Homicide-suicide in Hong Kong 1989-1998

This study provides the first systematic research of homicide-suicide (HS) in a Chinese society. Data were drawn from the HK Homicide Monitoring Data-base computer file derived from investigation and death reports held by the HK Police Force and the Coroner's Court. During the 10-year study period, 56 events involving 133 deaths were identified. The majority of offenders were males (75%) and most victims were female (64%). The mean age of offenders and victims were 41.9 and 32.3 years respectively. Spouses and lovers comprised the majority of victims (48.2%) followed by child victims (36%). Most HS events were motivated by separation or termination of marital or sexual relations (39%), economic reasons (25%) and other domestic disputes (20%). The most frequent modes of killing were strangulation/suffocation (26%), stabbing/chopping (24%), followed by gassing/poisoning (14%) and falling from a height (14%). The commonest method of suicide was falling from a height (48%). It was followed by gassing/poisoning (22%) and strangulation/suffocation (13%). Depression (18.3%) was found to be the commonest mental disorder. Most offenders were from low-socio economic background. Two-thirds were unemployed and 76.6% had 9 or less years of education. HS in HK were distinguished from those reported in the western literature in respect to the high relevance of economic factors, the absence of mercy killing between old couples, a higher percentage of pedicide-suicides and the infrequent use of firearms

DIALOG MANAGEMENT USING ACTIVE LEARNING ALGORITHMS

Master'sMASTER OF SCIENC

Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina

Age-related macular degeneration (AMD) is a leading cause of blindness. Vision loss is caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal and choroidal angiogenesis. Here we use AMD patient-specific RPE cells with the Complement Factor H Y402H high-risk polymorphism to perform a comprehensive analysis of extracellular vesicles (EVs), their cargo and role in disease pathology. We show that AMD RPE is characterised by enhanced polarised EV secretion. Multi-omics analyses demonstrate that AMD RPE EVs carry RNA, proteins and lipids, which mediate key AMD features including oxidative stress, cytoskeletal dysfunction, angiogenesis and drusen accumulation. Moreover, AMD RPE EVs induce amyloid fibril formation, revealing their role in drusen formation. We demonstrate that exposure of control RPE to AMD RPE apical EVs leads to the acquisition of AMD features such as stress vacuoles, cytoskeletal destabilization and abnormalities in the morphology of the nucleus. Retinal organoid treatment with apical AMD RPE EVs leads to disrupted neuroepithelium and the appearance of cytoprotective alpha B crystallin immunopositive cells, with some co-expressing retinal progenitor cell markers Pax6/Vsx2, suggesting injury-induced regenerative pathways activation. These findings indicate that AMD RPE EVs are potent inducers of AMD phenotype in the neighbouring RPE and retinal cells

The Moore Messenger

Weekly newspaper from Moore, Oklahoma that includes local, state, and national news along with advertising. The Moore Messenger was started on November 14, 1908 and was published by the Suburban Newspaper Publishing Company, which published four other papers in the county. The paper was issued weekly until June 1914, when it ceased publication

To Flee or Not: Postkilling responses among intimate partner homicide offenders in Hong Kong

Among 112 homicides involving sexual intimates that occurred in Hong Kong between 1989 and 2002, 38% (n = 42) of offenders remained voluntarily at the homicide scene, 21% (n = 24) committed suicide, 20% (n = 22) escaped and denied involvement, 13% (n = 14) disposed or hid the body of their victim, and 9% (n = 10) escaped but later voluntarily surrendered. This study used police investigation reports, coroner's reports, witness statements, and other relevant documents to compare these five types of postkilling behavior. The type of response was explained by the offender's characteristics, the strength of attachment to the victim, and situational factors. The offender's prior criminal conduct or history of violence was not significant in predicting the type of postkilling response

Quiet or questioning? Students' discussion behaviors in student-centered education across cultures

postprin