P2-498 Parents\u27 perceptions and practices regarding consanguinity related to β-thalassaemia: a matched case control study

introduction b-thalassaemia is most common genetically transmitted disorder in Eastern Mediterranean region including Pakistan. Like other recessive disorders, prevalence increases through consanguinity; Pakistan Demographic and Health Survey reports 50% consanguineous marriages. Perceptions about consanguinity in our population have recently not been studied. Objectives were to determine consanguinity related characteristics among parents of children with thalassaemia and without thalassaemia visiting a major health centre in Karachi-Pakistan. To compare consanguinity practices among such families and to assess susceptibility, benefits and barriers towards thalassaemia. Methods Sample of 340 cases and 340 controls; age-sex matched were selected from February to April 2010. Parents of thalassaemic children and parents of non-thalassaemic children were interviewed after consent. Consanguinity related characteristics followed in families were inquired. Perceptions regarding susceptibility to thalassaemia, benefits and barriers to screening were determined. Conditional logistic regression used to calculate matched OR. Parents’ approaches towards index child were assessed. Results Compared to no cousin marriage, parents of thalassaemic children had more cousin marriages (MOR: 7.3, 95% CI 3.6 to 14.6), and grand-parents cousin marriage (MOR: 2.8, 95% CI 1.8 to 4.4) than controls, more cousin marriages occurred in immediate family in last 5 years of cases than controls (MOR: 2.7, 95% CI 1.7 to 4.3) adjusting for ethnicity defined by mother tongue. Among case parents, (51%) were taking index child to social events and only 21% were satisfied with attitudes of other’s towards index child. Conclusion Study supports hypothesis that among parents of thalassaemic (cases), practices and perceptions favouring consanguinity were greater as compared to parents of non-thalassaemic children (controls)

Thermal slip in oblique radiative nano-polymer gel transport with temperature-dependent viscosity : solar collector nanomaterial coating manufacturing simulation

Nano-polymeric solar paints and sol-gels have emerged as a major new development in solar cell/collector coatings offering significant improvements in durability, anti-corrosion and thermal efficiency. They also exhibit substantial viscosity variation with temperature which can be exploited in solar collector designs. Modern manufacturing processes for such nano-rheological materials frequently employ stagnation flow dynamics under high temperature which invokes radiative heat transfer. Motivated by elaborating in further detail the nanoscale heat, mass and momentum characteristics, the present article presents a mathematical and computational study of the steady, two-dimensional, non-aligned thermo-fluid boundary layer transport of copper metal-doped water-based nano-polymeric sol gels under radiative heat flux. To simulate real nano-polymer boundary interface dynamics, thermal slip is analysed at the wall. A temperature-dependent viscosity is also considered. The conservation equations for mass, normal and tangential momentum and energy are normalized via appropriate transformations to generate a multi-degree, ordinary differential, non-linear, coupled boundary value problem. Numerical solutions are obtained via the stable, efficient Runge-Kutta-Fehlberg scheme with shooting quadrature in MATLAB symbolic software. Validation of solutions is achieved with a Variational Iterative Method (VIM) utilizing Langrangian multipliers. The impact of key emerging dimensionless parameters i.e. obliqueness parameter, radiation-conduction Rosseland number (Rd), thermal slip parameter (ALPHA), viscosity parameter (m), nanoparticles volume fraction (PHI) on non-dimensional normal and tangential velocity components, temperature, wall shear stress, local heat flux and streamline distributions is visualized graphically. Shear stress and temperature are boosted with increasing radiative effect whereas local heat flux is reduced. Increasing wall thermal slip parameter depletes temperatures

Electromagnetic Contributions to the Schiff Moment

The Schiff moment, \smij, is a parity and time reversal violating fermion-fermion coupling. The nucleus-electron Schiff moment generically gives the most important contribution to the electric dipole moments of atoms and molecules with zero net intrinsic electronic spin and nuclear spin ${1 \over 2}$. Here, the electromagnetic contribution to the Schiff moment, \emij, is considered. For a nucleon, the leading chirally violating contribution to this interaction is calculable in the chiral limit in terms of the parity and time reversal violating pion-nucleon coupling. For the Schiff moment of heavy nuclei, this chiral contribution is somewhat smaller than the finite size effect discussed previously in the literature.Comment: 7 pages, 1 figure (not included), Tex file, requires phyzzx, preprint SCIPP 93/4

Suppression of auxin stimulated growth of barley coleoptile sections by endosulfan

Endosulfan, a cyclic sulphurous acid ester commonly used as a broad spectrum insecticide, suppressed the elongation of barley coleoptiles. Indoleacetic acid at optimum concentration overcame the inhibition of growth of coleoptiles treated with 10 ppm endosulfan. However, perfusion of the coleoptile sections with endosulfan and subsequent treatment with indoleacetic acid could not stimulate cell elongation to the extent observed in the control

Microcrystalline Cellulose (MCC) from Oil Palm Empty Fruit Bunch (EFB) Fiber via Simultaneous Ultrasonic and Alkali Treatment

In this study, microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (EFB) cellulose which was earlier isolated from oil palm EFB fibre. In order to isolate the cellulose, the chlorination method was carried out. Then, the MCC was prepared by simultaneous ultrasonic and alkali treatment from the isolated α-cellulose. Based on mass balance calculation, the yields for MCC obtained from EFB was 44%. For fiber characterization, it is observed that the chemical composition of the hemicellulose and lignin for all samples decreased while composition for cellulose increased. The structural property of the MCC was studied by X-ray diffraction (XRD) method and the result shows that the MCC produced is a cellulose-I polymorph, with 73% crystallinity

Micro structure and Fractography of Multiwalled Carbon Nanotube Reinforced Unsaturated Polyester Nanocomposites

In this study unsaturated polyester resin (UPR) was reinforced with different concentration of predispersed multiwalled carbon nanotube (MWCNT). The rheology, structural analysis, fracture behavior, morphology, and thermal analysis of nanocomposites were carried out as a function of MWCNT content. Shear thinning behavior exhibited distinguishable dispersion quality of 0.3 wt% MWCNT in UPR matrix. Structural analysis reveals that MWCNT enhanced the nucleation of nanocomposites. The crystallinity of nanocomposites was increased by 71% after incorporation of 0.3 wt% MWCNT. Bending strength (BS) and bending modulus (BM) of nanocomposites were increased as well as 0.3 wt% MWCNT exhibited crack shielding in nanocomposites.The glass transition (Tg) and melting transition (Tm) of nanocomposites was increased by 68C and 108C respectively as compare to neat UPR. Additionally thermal stability of 0.3 wt% MWCNT incorporated nanocomposites was significantly improved as compare to UPR and nanocomposites which contained 0.1 and 0.5 wt% MWCN

Helimagnet-based non-volatile multi-bit memory units

In this Letter, we present a design of a helimagnet-based emerging memory device that is capable of storing multiple bits of information per device. The device consists of a helimagnet layer placed between two ferromagnetic layers, which allows us to lock-in specific spin configurations. The bottom pinned layer has high anisotropy energy or stays exchange biased, which keeps its spin configuration fixed on a specific direction, while the top layer is free to rotate under the influence of in-plane magnetic fields. We begin by finding the relaxed spin structure, which is the result of the competition between the Dzyaloshinskii–Moriya interaction (DMI) and exchange energy and is referred to as the equilibrium state (“0”). The writing of a memory state is simulated by applying an in-plane field that rotates and transforms the spin configurations of the memory device. Our results indicate that stable configurations can be achieved at rotations of an integer multiple of 180° (corresponding to states “−2,” “−1,” “1,” “2,” etc.), where the anisotropy stabilizes the free layer and, thus, the exchange coupled helimagnet. These states are separated by magnetic energy barriers and intermediate, unstable spin configurations tend to revert to their adjacent states. By simply changing the direction of the field, we can achieve multi-bit data storage per unit memory cell. The maximum number of bits is reached when the anisotropy energy barriers cannot withstand the strong DMI energy. Reading can be done by evaluating the different resistance states due to the twisted spin texture

Sensor networks security based on sensitive robots agents. A conceptual model

Multi-agent systems are currently applied to solve complex problems. The security of networks is an eloquent example of a complex and difficult problem. A new model-concept Hybrid Sensitive Robot Metaheuristic for Intrusion Detection is introduced in the current paper. The proposed technique could be used with machine learning based intrusion detection techniques. The new model uses the reaction of virtual sensitive robots to different stigmergic variables in order to keep the tracks of the intruders when securing a sensor network.Comment: 5 page

Remarks on the Upper Bounds on the Higgs Boson Mass from Triviality

We study the effects of the one-loop matching conditions on Higgs boson and top quark masses on the triviality bounds on the Higgs boson mass using $\beta_{\lambda}$ with corrected two-loop coefficients. We obtain quite higher results than previous ones and observe that the triviality bounds are not nearly influenced by varying top quark mass over the range measured at CDF and D0. The effects of typo errors in $\beta_{\lambda}^{(2)}$ and the one-loop matching condition on the top quark mass are negligible. We estimate the size of effects on the triviality bounds from the one-loop matching condition on the Higgs boson mass.Comment: 9 pages, tar'ed gzip'ed uuencoded files, LaTex, 5 PostScript figures. To appear in Physical Review