Is peak exposure to computer use a risk factor for neck and upper-extremity symptoms?

Objective Epidemiologic studies on physical exposure during computer use have mainly focused on average exposure duration. In this study, we aimed to relate periods of high peak exposure during computer use with the occurrence of neck-shoulder (NS) and arm-wrist-hand (AWH) symptoms. Methods A prospective cohort study among 1951 office workers was carried out for two years, with periodical questionnaires and continuous measurements of computer input use. To define peak exposure, a distinction was made between peak days and weeks. Peak days were defined as days with a long duration of computer (ie, ≥4 hours) or mouse use (ie, ≥2.5 hours) or days with high frequency of mouse (ie, ≥20 clicks per minute) or keyboard use (ie, ≥160 keystrokes per minute). Weeks containing ≥3 peak days were considered peak weeks. Independent variables were numbers of peak days and peak weeks during a 3-month measurement period; dependent variables were self-reported NS and AWH symptoms during the following 3-month measurement period. Results Valid data were available for 2116 measurements of 774 office workers. No relation was found between any of the peak exposure parameters and AWH symptoms or with peak exposure in duration and NS symptoms. Most parameters referring to high frequency-related peak exposure were associated with less NS symptoms, but the effect estimates were very small and the confidence intervals close to the null. Conclusion In this study, we found no indication that high peaks in computer use were related to the occurrence of NS or AWH symptoms. This work is licensed under a Creative Commons Attribution 4.0 International License

Modelling the epidemiology of salmonella in the pork supply chain

The interest in reducing the incidence of food-borne diseases, such as salmonellosis caused by pork is increasing. All stages in the pork supply chain can take preventive and reductive measures to decrease the Salmonella prevalence. But it is necessary to have insight in the effect of these measures on the final prevalence of contaminated carcasses. In this way imposing expensive but ineffective measures can be avoided. In order to be able to obtain such evaluations, a stochastic state-transition model is designed. Five stages are included (from piglet to carcass) and two risk-profiles are formulated for each stage: high-risk and low-risk. Scenario studies with the model indicate that all stages may contribute to an increased food safety. The impact of the multiplying stage is limited, because the animals may recover during the finishing stage. Recovery after the finishing stage is not possible, although the transport and lairage can prevent further transmission. At the slaughterhouse the number of contaminated carcasses is highly determined by the prevalence of the supplied animals and the risk profile. Measures in the finishing stage are effective in the reduction of Salmonella in pork, but may be cancelled out if the following stages do not take preventive and reductive measures

Observed differences in upper extremity forces, muscle efforts, postures, velocities, and accelerations across computer activities in a field study of office workers

This study, a part of the PRedicting Occupational biomechanics in OFfice workers (PROOF) study, investigated whether there are differences in field-measured forces, muscle efforts, postures, velocities and accelerations across computer activities. These parameters were measured continuously for 120 office workers performing their own work for two hours each. There were differences in nearly all forces, muscle efforts, postures, velocities and accelerations across keyboard, mouse and idle activities. Keyboard activities showed a 50% increase in the median right trapezius muscle effort when compared to mouse activities. Median shoulder rotation changed from 25 degrees internal rotation during keyboard use to 15 degrees external rotation during mouse use. Only keyboard use was associated with median ulnar deviations greater than 5 degrees. Idle activities led to the greatest variability observed in all muscle efforts and postures measured. In future studies, measurements of computer activities could be used to provide information on the physical exposures experienced during computer use. Practitioner Summary: Computer users may develop musculoskeletal disorders due to their force, muscle effort, posture and wrist velocity and acceleration exposures during computer use. We report that many physical exposures are different across computer activities. This information may be used to estimate physical exposures based on patterns of computer activities over time. © 2012 Copyright Taylor and Francis Group, LLC

Onderzoek naar het voorkomen van DES in vlees

Door de Veterinaire Dienst te 's- Hertogenbosch zijn monsters rundvlees genomen op het Openbaar Slachthuis te Breda. Deze monsters zijn op het RIKILT onderzocht met LC-EC , en in een aantal gevallen met GC-MS

Crystallization of the ordered vortex phase in high temperature superconductors

The Landau-Khalatnikov time-dependent equation is applied to describe the crystallization process of the ordered vortex lattice in high temperature superconductors after a sudden application of a magnetic field. Dynamic coexistence of a stable ordered phase and an unstable disordered phase, with a sharp interface between them, is demonstrated. The transformation to the equilibrium ordered state proceeds by movement of this interface from the sample center toward its edge. The theoretical analysis dictates specific conditions for the creation of a propagating interface, and provides the time scale for this process.Comment: 8 pages and 3 figures; to be published in Phys. Rev. B (Rapid Communications section

The ACE I/D polymorphism does not explain heterogeneity of natural course and response to enzyme replacement therapy in Pompe disease

The majority of children and adults with Pompe disease in the population of European descent carry the leaky splicing GAA variant c.-32-13T>G (IVS1) in combination with a fully deleterious GAA variant on the second allele. The phenotypic spectrum of this patient group is exceptionally broad, with symptom onset ranging from early infancy to late adulthood. In addition, the response to enzyme replacement therapy (ERT) varies between patients. The insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) has been suggested to be a modifier of disease onset and/or response to ERT. Here, we have investigated the effect of the ACE I/D polymorphism in a relatively large cohort of 131 children and adults with Pompe disease, of whom 112 were followed during treatment with ERT for 5 years. We assessed the use of wheelchair and mechanical ventilation, muscle strength assessed via manual muscle testing and hand-held dynamometry (HHD), distance walked on the six-minute walk test (6MWT), forced vital capacity (FVC) in sitting and supine position and daily-life activities assessed by R-PAct. Cross sectional analysis at first visit showed no differences between the genotypes with respect to age at first symptoms, diagnosis, wheelchair use, or ventilator use. Also response to ERT over 5 years assessed by linear mixed model analyses showed no significant differences between ACE groups for any of the outcome measures. The patient cohort contained 24 families with 54 siblings. Differences in ACE genotype could neither explain inter nor intra familial differences. We conclude that the ACE I/D polymorphism does not explain the large variation in disease severity and response to ERT observed among Pompe patients with the same c.-32-13T>G GAA variant

Elementary vortex pinning potential in a chiral p-wave superconductor

The elementary vortex pinning potential is studied in a chiral p-wave superconductor with a pairing d=z(k_x + i k_y) on the basis of the quasiclassical theory of superconductivity. An analytical investigation and numerical results are presented to show that the vortex pinning potential is dependent on whether the vorticity and chirality are parallel or antiparallel. Mutual cancellation of the vorticity and chirality around a vortex is physically crucial to the effect of the pinning center inside the vortex core.Comment: 4 pages, 4 figures include