The Complement System: A Potential Target for Stroke Therapy

Anti-complement strategies appear to hold great promise for the development of stroke therapeutics. Yet caution should be exercised. It is clear that the complement cascade is a complex and intricate system with widely varied effects, and if any knowledge has been gained from the many failed attempts at translating stroke therapies to the bedside, it is that cavalier application of under-elucidated therapies that leads to wasted resources and the potential for poor patient outcomes

Family firms going international: Integrating corporate identity‐building processes and socioemotional wealth dimensions

This study aims to improve understanding of how identity-building processes shape corporate identity and how dimensions of socioemotional wealth affect internationalization pathways in a family firm. The paper uses an in-depth case study of an Italian family firm internationally recognized as excellent in its industry. We developed an integrative theoretical model, combining socioemotional wealth frameworks and elements of the corporate identity mix. This enabled us to incorporate more theoretical knowledge from the field of international management into the domain of family business research. The latent construct of socioemotional wealth provides an in-depth understanding of the multidimensional nature of corporate identity-building processes and shows the intertwined nature of corporate identity and the "affective endowment" in the development of internationalization strategies

Problematic pigmented lesions: approach to diagnosis

A number of pigmented lesions are difficult to classify and raise the possibility of a melanoma diagnosis. Care should be exercised to exclude non-melanocytic lesions, and benign melanocytic entities, both of which can mimic melanoma histologically. In addition, the possibility of the lesion being a melanoma variant or epidermotropic metastasis should be considered. There will still be some cases that are difficult to resolve. These usually fall into one of three categories: atypical junctional melanocytic lesion versus early melanoma; naevus versus naevoid melanoma; and atypical Spitz, cellular blue, and deep penetrating naevi versus thick melanoma. These will pose problems even for experts. The atypical Spitz lesions are perhaps the most important category because they tend to be from younger individuals, the differential diagnosis is thick melanoma, and there is no single discriminating histological feature. Key Words: difficult diagnosis • pigmented lesions • melanom