Scaling the Stiffness, Strength, and Toughness of Ceramic‐Coated Nanotube Foams into the Structural Regime

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108652/1/adfm201400851-sup-0001-S1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/108652/2/adfm201400851.pd

Design, synthesis, and antitumor efficacy of novel 5-deazaflavin derivatives backed by kinase screening docking and ADME studies

open access articleNovel 5-deazaflavins were designed as potential anticancer candidates. Compounds 4j, 4k, 5b, 5i, and 9f demonstrated high cytotoxicity against MCF-7 cell line with IC50 of 0.5–190nM. Compounds 8c and 9g showed preferential activity against Hela cells (IC50: 1.69 and 1.52 μM respectively). However, compound 5d showed notable potency against MCF-7 and Hela cell lines of 0.1 nM and 1.26 μM respectively. Kinase profiling for 4e showed the highest inhibition against a 20 kinase panel. Additionally, ADME prediction studies exhibited that compounds 4j, 5d, 5f, and 9f have drug-likeness criteria to be considered promising antitumor agents deserving of further investigation. SAR study showed that substitutions with 2-benzylidene hydra zino have a better fitting into PTK with enhanced antiproliferative potency. Noteworthy, the incorporation of hydrazino or ethanolamine moieties at position 2 along with small alkyl or phenyl at N-10, respectively revealed an extraordinary potency against MCF-7 cells with IC50 values in the nanomolar range

Adaptability of Sift Potato Genotypes in Different Agro-Ecologies of Uganda

The effect of genotype by environment interaction (G x E) on fresh tuber yield of nine Standard International Field Trials (SIFT) potato (Solanum tuberosum L.) genotypes and Kisoro, a local variety, was studied in Uganda using additive main effects and multiplicative interaction (AMMI) model 3. Results indicated that the proportion of the environmental variation was much larger than the proportion due to genotypes and the proportion due to G x E interaction was also larger than the genotype main effects. Genotypes (G), environments (E) and the G x E interactions accounted for 8.43, 57.13 and 34.44% of the treatment sums of squares, respectively. AMMI and the biplot identified genotypes 384866.5, 381381.13, 389746.2, Kisoro and 386209.10 as adapted to four environments. Test genotypes 389746.2, Robijn and 381381.13 were the most stable and had higher yields (> 19 t ha-1) than all genotypes except Torridon, which was also very unstable and specifically adapted to one environment (Kalengyere 2B). Kalengyere 1B and Wanale 2A were identified as similar environments

Resistance to late blight and yield of population B3 potato selection in Uganda

No Abstract. African Crop Science Journal Vol. 13(2) 2005: 95-10

Adaptability of sift potato genotypes in different agro-ecologies of Uganda

No Abstract. African Crop Science Journal Vol. 13(2) 2005: 107-11

Resistance to Late Blight and Yield of Population B3 Potato Selections in Uganda

Population B3 is the most advanced source of horizontal resistance available at the International Potato Centre (CIP). In this population, testing and selection for horizontal resistance to late blight, unlike those previously applied to population A clones, were simplified significantly (P<0.05) due to the absence of known R-genes. This study, conducted in southwestern and eastern Uganda, evaluated 20 selected potato genotypes in Population B3 for late blight resistance and tuber yield. Late blight severities on many of the Population B3 genotypes were lower than on most local cultivars, including the resistant cultivar, Rutuku. Population B3 genotypes performed better when sprayed with fungicide, Mancozeb, but the reduction in late blight severities due to spraying varied with genotype and location. Although spraying did not significantly (P>0.05) increase yields, almost all genotypes gave higher yields with than without spraying, with significant (P<0.05) differences among genotypes. Population B3 entries 389746.2, 383382.44, 393371.58, 392637.10, 391002.6, 393349.63, 393617.18, 391011.17, 391580.30, 393385.39, 393339.242, 393077.54, 393280.64 and 392657.8 performed well and could be considered for on-farm trials