Accuracy of wives' proxy reports of husbands' fertility preferences in sub-Saharan Africa

Background: Demographic researchers have recognized the importance of male partners in reproductive behavior and decision-making. Yet much of the existing literature still relies on female respondents reporting on behalf of their spouses. Objective: The objective of this study is to estimate the accuracy of wives' reports of husbands' fertility preferences in 32 countries in sub-Saharan Africa. Methods: We used couple-level data from Demographic and Health Surveys to evaluate the accuracy of wives' reports of their husbands' fertility preferences in 32 countries in sub-Saharan Africa. We created a measure of accuracy based on each partner's response to a set of fertility preference questions. We examined the overall percentages of wives who were accurate, inaccurate, or uncertain across countries. Results: Despite the fact that most couples were concordant in wanting more children, we found variation in the percentages of wives who were accurate in their proxy reports, ranging from 26Š in Chad to 58Š in Rwanda. By contrast, percentages of wives who were inaccurate were similar; approximately one-third of wives across all countries gave proxy responses that were at odds with their husbands' responses. Large percentages of wives were uncertain of their husbands' fertility preferences, reaching 50Š in Comoros. Conclusions: These findings indicate low levels of spousal discussion of fertility preferences. We encourage survey organizations to invest in collecting data from males directly. Contribution: By demonstrating that majorities of wives across countries either inaccurately perceive or are uncertain of their husband's fertility preferences, the current study justifies collecting data from male partners directly

Terminal Care and The Value of Life Near Its End

Medical care at the end of life, estimated to contribute up to a quarter of US health care spending, often encounters skepticism from payers and policy makers who question its high cost and often minimal health benefits. However, though many observers have claimed that such spending is often irrational and wasteful, little explicit analysis exists on the incentives that determine end of life health care spending. This paper attempts to provide the first rational and systematic analysis of the incentives behind end of life care. The main argument we make is that existing theoretical and empirical analysis of the value of life do not apply, and often under-values, the value of life near its end and terminal care. We argue that several factors drive up the value of life near its end including the low opportunity cost of medical spending near ones death, the value of hope including living into new innovations, and the potential positive effect of on the value of life from being frail. We calibrate the ex-post value of hope associated with treatments for HIV patients to be as much as four times as high as standard per-capita estimates of treatment effects and as many as two and a half times as high as aggregate values across all cohorts.

Design and validation of a German version of the GSRS-IBS - an analysis of its psychometric quality and factorial structure

Background: Currently, a suitable questionnaire in German language is not available to monitor the progression and evaluate the severity of irritable bowel syndrome (IBS). Therefore, this study aimed to translate the Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome (GSRS-IBS) into German and to evaluate its psychometric qualities and factorial structure. Methods: This study is based on a total sample of 372 participants [62.6% female, mean age = 41 years (SD = 17 years)]. 17.5% of the participants had a diagnosis of IBS, 19.9% were receiving treatment for chronic inflammatory bowel disease, 12.1% of the participants were recruited from a psychosomatic clinic, and 50.5% belonged to a control group. All participants completed the German version of GSRS-IBS (called Reizdarm-Fragebogen, RDF), as well as the Gießen Subjective Complaints List (GBB-24) and the Hospital Anxiety and Depression Scale - German version (HADS-D). Results: The internal consistency of the RDF total scale was at least satisfactory in all subsamples (Cronbach’s Alpha between .77 and .92), and for all subscales (Cronbach’s Alpha between .79 and .91). The item difficulties (between .25 and .73) and the item-total correlations (between .48 and .83) were equally satisfactory. Principal axis analysis revealed a four-factorial structure of the RDF items, which mainly resembled the structure of the English original. Convergent validity was established based on substantial and significant correlations with the stomach-complaint scale of the GBB-24 (r = .71; p < .01) and the anxiety (r = .42; p < .01) and depression scales (r = .43; p < .01) of the HADS-D. Conclusion: The German version of the GSRS-IBS RDF proves to be an effective, reliable, and valid questionnaire for the assessment of symptom severity in IBS, which can be used in clinical practice as well as in clinical studies

NFkB Disrupts Tissue Polarity in 3D by Preventing Integration of Microenvironmental Signals

The microenvironment of cells controls their phenotype, and thereby the architecture of the emerging multicellular structure or tissue. We have reported more than a dozen microenvironmental factors whose signaling must be integrated in order to effect an organized, functional tissue morphology. However, the factors that prevent integration of signaling pathways that merge form and function are still largely unknown. We have identified nuclear factor kappa B (NFkB) as a transcriptional regulator that disrupts important microenvironmental cues necessary for tissue organization. We compared the gene expression of organized and disorganized epithelial cells of the HMT-3522 breast cancer progression series: the non-malignant S1 cells that form polarized spheres (\u27acini\u27), the malignant T4-2 cells that form large tumor-like clusters, and the \u27phenotypically reverted\u27 T4-2 cells that polarize as a result of correction of the microenvironmental signaling. We identified 180 genes that display an increased expression in disorganized compared to polarized structures. Network, GSEA and transcription factor binding site analyses suggested that NFkB is a common activator for the 180 genes. NFkB was found to be activated in disorganized breast cancer cells, and inhibition of microenvironmental signaling via EGFR, beta1 integrin, MMPs, or their downstream signals suppressed its activation. The postulated role of NFkB was experimentally verified: Blocking the NFkB pathway with a specific chemical inhibitor or shRNA induced polarization and inhibited invasion of breast cancer cells in 3D cultures. These results may explain why NFkB holds promise as a target for therapeutic intervention: Its inhibition can reverse the oncogenic signaling involved in breast cancer progression and integrate the essential microenvironmental control of tissue architecture

Rapid analysis of magnesium in infant formula powder using laser-induced breakdown spectroscopy

Laser-induced breakdown spectroscopy (LIBS) was investigated to determine magnesium (Mg) content in infant formula powder. To predict Mg content in the range established by the Codex Alimentarius, a partial least squares regression (PLSR) model was developed using a calibration data set (n = 30) based on full cross-validation and validated using an independent validation data set (n = 21). The prediction model performance was evaluated using the regression coefficients of determination (Rcv2 = 0.94 and Rp2 = 0.85) with the root mean square errors on cross-validation and prediction (RMSECV = 60 mg kg−1 and RMSEP = 80 mg kg−1). The limit of detection (150 mg kg−1) was also calculated. In addition, LIBS successfully predicted the Mg content distributed within a pellet. This study demonstrated that LIBS is suitable as a rapid reagent-free method for the quantification of Mg in powdered infant formula and can provide spatial information with acceptable accuracy

A Community in Bloom: An affordable housing needs assessment of West Bloomington

Purpose of Report This report was written in response to a request from Habitat for Humanity of McLean County. The report expands upon and updates an affordable homeownership needs assessment for the Bloomington-Normal community – with an emphasis on West Bloomington – that was created in 2004. Because the housing market and economic conditions of the area have changed drastically in the last 6 years, an updated report is necessary. Data Sources and Methodology This report uses a combination of primary and, mainly, secondary data sources. Interviews were conducted with representatives of, among others, Bloomington Housing Authority, the Economic Development Council (EDC) of Bloomington-Normal Area, Mid Central Community Action, Prairie State Legal Services, and the West Bloomington Revitalization Project. A variety of data were gathered from secondary sources, such as the U.S. Department of Housing and Urban Development (HUD), the U.S. Census, the City of Bloomington, the U.S. Bureau of Labor Statistics, Mid Central Community Action, the National Association of Realtors, and the National Low Income Housing Coalition (NLIHC)

Why are the K dwarfs in the Pleiades so Blue?

The K dwarfs in the Pleiades fall nearly one half magnitude below a main sequence isochrone when plotted in a color-magnitude diagram utilizing V magnitude as the luminosity index and B-V as the color index. This peculiarity has been known for forty years but has gone unexplained and mostly ignored. When compared to Praesepe members, the Pleiades K dwarfs again are subluminous (or blue) in a color-magnitude diagram using B-V as the color index. However, using V-I as the color index, stars in the two clusters are coincident to M_V ~ 10; using V-K as the color index, Pleiades late K and M stars fall above the main sequence locus defined by Praesepe members. We believe that the anomalous spectral energy distributions for the Pleiades K dwarfs, as compared to older clusters, are a consequence of rapid stellar rotation and may be primarily due to spottedness. If so, the required areal filling factor for the cool component has to be very large (=> 50%). Weak-lined T Tauri stars have similar color anomalies, and we suspect this is a common feature of all very young K dwarfs (sp. type > K3). The peculiar spectral energy distribution needs to be considered in deriving accurate pre-main sequence isochrone-fitting ages for clusters like the Pleiades since the age derived will depend on the temperature index used.Comment: 41 pages, 15 figures, AASTeX5.0. Accepted 05 May 2003; Scheduled for publication in the Astronomical Journal (August 2003

Food for contagion : synthesis and future directions for studying host-parasite responses to resource shifts in anthropogenic environments

Human-provided resource subsidies for wildlife are diverse, common and have profound consequences for wildlife-pathogen interactions, as demonstrated by papers in this themed issue spanning empirical, theoretical and management perspectives from a range of study systems. Contributions cut across scales of organization, from the within-host dynamics of immune function, to population-level impacts on parasite transmission, to landscape-and regional-scale patterns of infection. In this concluding paper, we identify common threads and key findings from author contributions, including the consequences of resource subsidies for (i) host immunity; (ii) animal aggregation and contact rates; (iii) host movement and landscape-level infection patterns; and (iv) interspecific contacts and cross-species transmission. Exciting avenues for future work include studies that integrate mechanistic modelling and empirical approaches to better explore cross-scale processes, and experimental manipulations of food resources to quantify host and pathogen responses. Work is also needed to examine evolutionary responses to provisioning, and ask how diet-altered changes to the host microbiome influence infection processes. Given the massive public health and conservation implications of anthropogenic resource shifts, we end by underscoring the need for practical recommendations to manage supplemental feeding practices, limit human-wildlife conflicts over shared food resources and reduce cross-species transmission risks, including to humans. This article is part of the theme issue 'Anthropogenic resource subsidies and host-parasite dynamics in wildlife'.Peer reviewe