136 research outputs found
Second malignancies in breast cancer patients following radiotherapy: a study in Florence, Italy.
ntroduction: Patients diagnosed with breast cancer are often treated with surgery followed by radiation therapy. In this paper, we evaluate the effect that radiotherapy may have had on the subsequent risk of second malignancies, including the possible influences of age at treatment and menopausal status.Methods: In order to evaluate the long-term consequences of radiotherapy, a cohort study was conducted based on clinical records for 5,248 women treated for breast cancer in Florence (Italy), with continuous follow-up from 1965 to 1994. The Cox proportional hazards model for ungrouped survival data was used to estimate the relative risk for second cancer after radiotherapy.Results: This study indicated an increased relative risk of all second cancers combined following radiotherapy (1.22, 95% CI: 0.88 to 1.69). The increased relative risk appeared five or more years after radiotherapy and appeared to be highest amongst women treated after the menopause (1.61, 95% CI: 1.13 to 2.29). Increased relative risks were observed specifically for leukaemia (8.13, 95% CI: 0.96 to 69.1) and other solid cancers (1.84, 95% CI: 1.06 to 3.16), excluding contralateral breast cancer. For contralateral breast cancer, no raised relative risk was observed during the period more than five years after radiotherapy.Conclusions: The study indicated a raised risk of second malignancies associated with radiotherapy for breast cancer, particularly for women treated after the menopause
NITROXIDES AND MALIGNANT HUMAN TISSUES: ELECTRON SPIN RESONANCE IN COLORECTAL NEOPLASTIC AND HEALTHY TISSUES.
Massive Pions, Anomalies and Baryons in Holographic QCD
We consider a holographic model of QCD, obtained by a very simple
modification of the original construction, which describes at the same time the
pion mass, the QCD anomalies and the baryons as topological solitons. We study
in detail its phenomenological implications in both the mesonic and baryonic
sectors and compare with the observations.Comment: 31 pages, 2 figures; v2: Version published in Nucl. Phys.
Prognostic significance of biological markers in node-negative breast cancer patients: a prospective study
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