Rhodium-Catalyzed Endo -Selective Epoxide-Opening Cascades: Formal Synthesis of (−)-Brevisin

[Rh(CO)₂Cl]₂ is as an effective catalyst for endo-selective cyclizations and cascades of epoxy-(E)-enoate alcohols, thus enabling the synthesis of oxepanes and oxepane-containing polyethers from di- and trisubstituted epoxides. Syntheses of the ABC and EF ring systems of (−)-brevisin via all endo-diepoxide-opening cascades using this method constitute a formal total synthesis and demonstrate the utility of this methodology in the context of the synthesis of marine ladder polyether natural products.National Institute of General Medical Sciences (U.S.) (GM72566)National Institute of General Medical Sciences (U.S.) (F32GM095014

Stereoelectronic Model To Explain Highly Stereoselective Reactions of Seven-Membered-Ring Oxocarbenium-Ion Intermediates

Nucleophilic attack on seven-membered-ring oxocarbenium ions is generally highly stereoselective. The preferred mode of nucleophilic attack forms the product in a conformation that minimizes transannular interactions, thus leading to different stereoselectivity as compared to that of reactions involving six-membered-ring oxocarbenium ions

Criminal Victimization and Comorbid Substance Use and Psychiatric Disorders in the United States: Results from the NESARC

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78033/1/45.pd

Correlates of cruelty to animals in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions

OBJECTIVE: To examine the sociodemographic, behavioral, and psychiatric correlates of cruelty to animals in the US. MATERIALS AND METHODS: Data were derived from a nationally representative sample of adults residing in the US Structured psychiatric interviews (N=43,093) were completed by trained lay interviewers between 2001 and 2002. Personality, substance use, mood, and anxiety disorders and cruelty to animals were assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (DSM-IV) version. RESULTS: The lifetime prevalence of animal cruelty in US adults was 1.8%. Men, African-Americans, Native-Americans/Asians, native-born Americans, persons with lower levels of income and education and adults living the western region of the US reported comparatively high levels of cruelty to animals, whereas Hispanics reported comparatively low levels of such behavior. Cruelty to animals was significantly associated with all assessed antisocial behaviors. Adjusted analyses revealed strong associations between lifetime alcohol use disorders, conduct disorder, antisocial, obsessive-compulsive, and histrionic personality disorders, pathological gambling, family history of antisocial behavior, and cruelty to animals. CONCLUSIONS: Cruelty to animals is associated with elevated rates observed in young, poor, men with family histories of antisocial behavior and personal histories of conduct disorder in childhood, and antisocial, obsessive-compulsive and histrionic personality disorders, and pathological gambling in adulthood. Given these associations, and the widespread ownership of pets and animals, effective screening of children, adolescents and adults for animal cruelty and appropriate mental health interventions should be deployed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78171/1/sdarticle-1.pd

Psychiatric Correlates of Bullying in the United States: Findings from a National Sample

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78043/1/65.pd

Prevalence and correlates of fire-setting in the United States: results from the National Epidemiological Survey on Alcohol and Related Conditions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78028/1/40.pd

Sociodemographic, behavioral, and substance use correlates of reckless driving in the United States: Findings from a national Sample

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78094/1/70.pd

Prevalence and Correlates of Fire-Setting in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions

Fire-setting is a serious and costly form of antisocial behavior. Our objective in this study was to examine the prevalence and correlates of intentional fire-setting behavior in the U. S. Data were derived from a nationally representative sample of U.S. residents 18 years and older. Structured psychiatric interviews (N = 43,093) were completed by trained lay interviewers between 2001-2002. Fire-setting and DSM-IV mood, anxiety, substance use and personality disorders were assessed with the Alcohol Use Disorder and Associated Disabilities Interview Schedule (DSM-IV) version. The prevalence of lifetime fire-setting in the U.S. population was 1.0%. Respondents who were men, Caucasian, 18 to 35, born in the U.S., and living in the western region of the U.S. had significantly higher rates of fire-setting than their counterparts. Fire-setting was significantly associated a wide range of antisocial behaviors. Multivariate logistic regression analyses identified strong associations between lifetime alcohol and marijuana use disorders, conduct disorder, antisocial and obsessive-compulsive personality disorders, and family history of antisocial behavior. Intentional illicit fire-setting behavior is associated with a broad array of antisocial behaviors and psychiatric comorbidities. Given the substantial personal and social costs related to arson, prevention and treatment interventions targeting fire-setters potentially could save lives and property

Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/1/cpt1747.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/2/cpt1747-sup-0001-FigS1.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154656/3/cpt1747_am.pd

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

SummaryWe report a comprehensive molecular characterization of pheochromocytomas and paragangliomas (PCCs/PGLs), a rare tumor type. Multi-platform integration revealed that PCCs/PGLs are driven by diverse alterations affecting multiple genes and pathways. Pathogenic germline mutations occurred in eight PCC/PGL susceptibility genes. We identified CSDE1 as a somatically mutated driver gene, complementing four known drivers (HRAS, RET, EPAS1, and NF1). We also discovered fusion genes in PCCs/PGLs, involving MAML3, BRAF, NGFR, and NF1. Integrated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype, a pseudohypoxia subtype, a Wnt-altered subtype, driven by MAML3 and CSDE1, and a cortical admixture subtype. Correlates of metastatic PCCs/PGLs included the MAML3 fusion gene. This integrated molecular characterization provides a comprehensive foundation for developing PCC/PGL precision medicine