The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system

Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 42-kDa mouse Inpp5k protein. Inpp5k transgenic mice present defects in water metabolism characterized by a reduced plasma osmolality at baseline, a delayed urinary water excretion following a water load, and an increased acute response to vasopressin. These defects are associated with the expression of the Inpp5k transgene in renal collecting ducts and with alterations in the arginine vasopressin/aquaporin-2 signalling pathway in this tubular segment. Analysis in a mouse collecting duct mCCD cell line revealed that Inpp5k overexpression leads to increased expression of the arginine vasopressin receptor type 2 and increased cAMP response to arginine vasopressin, providing a basis for increased aquaporin-2 expression and plasma membrane localization with increased osmotically induced water transport. Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting duct

Physiologie générale :Introduction à la biologie humaine

SYL-002050 = Fascicule 1Syllabus strictement réservé aux étudiants suivant le cours de 2e Candidature Médecine - PATO 058info:eu-repo/semantics/published

Physiologie générale: Introduction à la biologie humaine des molécules aux fonctions

SYL-8688 = Fascicule 2MED2, VETE2, BIME2B, DENT2 - PATO058info:eu-repo/semantics/published

Physiologie générale :Introduction à la biologie humaine des molécules aux fonctions

SYL-10002 = Fascicule 1MED2, VETE2, BIME2, DENT2, MEDI-G-204info:eu-repo/semantics/published1

Role of proton pumps in urinary acidification and alkalinization

Thèse d'agrégation de l'enseignement supérieur (Faculté de médecine) -- UCL, 198

Physiologie générale :Introduction à la biologie humaine des molécules aux fonctions

SYL-007519 = Fascicule 1 ;SYL-007546 = Fascicule 2MED2, VETE2, BIME2B, DENT2 - MEDI-G-204info:eu-repo/semantics/published1

Physiologie générale :Introduction à la biologie humaine des molécules aux fonctions

SYL-007565 = Fascicule 1 ;SYL-10004 = Fascicule 2MED2, VETE2, BIME2, DENT2 - MEDI-G-204info:eu-repo/semantics/published1

Physiologie générale :introduction à la biologie humaine

SYL-5407 = Fascicule 1 ;SYL-3659 = Fascicule 2Fascicule 1 :5e édition 1994-1995/1 ;Fascicule 2 :5e édition 1992-1993/1MEDinfo:eu-repo/semantics/published

Physiologie générale :introduction à la biologie humaine

SYL-3658 = Fascicule 1 ;SYL-4899 = Fascicule 24e édition 1992-1993/1info:eu-repo/semantics/published

Physiologie générale :Introduction à la biologie humaine

SYL-002451 = Fascicule 1 ;SYL-002452 = Fascicule 26e édition 1995-1996/1MEDinfo:eu-repo/semantics/published