4 research outputs found

    Quels sont les impacts des lieux de vie à structure et approche innovante sur la qualité de vie des personnes atteintes de démence ?: revue de littérature

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    Cette revue de littérature a pour but de comparer les impacts sur la qualité de vie des personnes avec démence, entre des lieux de vie traditionnels et des lieux d'accueil innovants. En effet, la maladie d'Alzheimer et les démences apparentées sont actuellement un problème de santé publique majeur et mondial particulièrement dans la prise en charge de ces personnes en institution. Par ailleurs, l'augmentation de la population vieillissante est en corrélation directe avec l'augmentation du nombre de malades. Ainsi donc, la prise en charge de ces personnes devient un défi prioritaire et d'envergure

    Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment.

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    Childhood cancer survivors (CCS) are more likely than siblings to report low sperm count and to use assisted reproductive technologies. Yet, it is still unclear if the sperm produced many years after remission of cancer display DNA and chromatin damage linked to male infertility and poor embryo development. As well, the importance of the age at diagnosis in relation to puberty is poorly understood. In this pilot study, we compared reproductive parameters and sperm damage from adult survivors of childhood leukemia and lymphoma, sub-divided into those diagnosed before or after puberty, to men with no history of cancer. Our data indicate that CCS, independently of the age of diagnosis, have a high risk of low sperm count and when sperm are present, chances of DNA and chromatin abnormalities appear similar to those seen in the general population. Exposure to alkylating agents is correlated with low sperm count whereas exposure to anthracyclines, and doxorubicin in particular, could have long-term consequences on sperm integrity. This study highlights the need for further research on fertility among male CCS and the importance of informing families about the potential long-term impact of chemotherapy on male fertility regardless of age at diagnosis
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