24 research outputs found
Intracultivar selection for seed quality of soybeans in an ultra-low-density selection model (Honeycomb Selection Designs)
Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil
Intensity of bitterness of processed yerba mate leaves originated in two contrasted light environments
Composto de resíduos da fabricação de papel e celulose na produção de mudas de eucalipto
Educação científica na perspectiva de letramento como prática social: funções, princípios e desafios
Desenvolvimento de dominãncia apical e ramificações no crescimento vegetativo de plantulas de Ilex paraguariensis (St. Hil.) Aquifoliacea.
EVINCI. Resumo
O efeito do nitrogênio no crescimento vegetativo em Ilex paraguariensis (St. Hill.) Aquifoliaceae.
EVINCI. Resumo
Acetylcholinesterase inhibitory activity, anti-inflammatory, and neuroprotective potential of Hippeastrum psittacinum (Ker Gawl.) herb (Amaryllidaceae)
Hippeastrum psittacinum, Amaryllidaceae, is used in traditional medicine as a purgative, aphrodisiac, and anticough remedy. The ethanol extract (EE) and alkaloid-rich fractions (ARF) from H. psittacinum bulbs were evaluated for their acetylcholinesterase (AChE) inhibition. The EE cytotoxic and anti-inflammatory effects in RAW 264.7 cells, and the neuroprotective and genotoxic activities in SH-SY5Y cells, were also estimated. Fifteen alkaloids were identified in the EE by gas chromatography–mass spectrometry. ARFs were less active for AChE inhibition than EE. The viability of both cell lines was higher than 70% with EE concentrations below 25 μg/mL. The EE decreased nitrite release in RAW cells stimulated with lipopolysaccharide, showing values of 83, 67, and 53% at 6.25, 12.5, and 25 μg/mL, respectively. Furthermore, the EE partially protected SH-SY5Y cells from hydrogen peroxide-mediated deleterious effects by approximately 50% at the same concentrations. The micronucleus assays showed that the extract caused chromosomal missegregation at concentrations above 12.5 μg/mL. The in silico analyses showed that some alkaloids presented properties of permeation of the blood-brain barrier and the intestine. Our findings present new evidence of the potential of H. psittacinum potential as an AChE inhibitor, as well as an anti-inflammatory and neuroprotective agent