A Lattice Boltzmann Method for relativistic rarefied flows in (2+1) dimensions

We propose an extension to recently developed Relativistic Lattice Boltzmann solvers (RLBM), which allows the simulation of flows close to the free streaming limit. Following previous works Ambruş and Blaga (2018), we use product quadrature rules and select weights and nodes by separately discretizing the radial and the angular components. This procedure facilitates the development of quadrature-based RLBM with increased isotropy levels, thus improving the accuracy of the method for the simulation of flows beyond the hydrodynamic regime. In order to quantify the improvement of this discretization procedure over existing methods, we perform numerical tests of shock waves in one and two spatial dimensions in various kinetic regimes across the hydrodynamic and the free-streaming limits

Fast kinetic simulator for relativistic matter

Relativistic kinetic theory is ubiquitous to several fields of modern physics, finding application at large scales in systems in astrophysical contexts, all of the way down to subnuclear scales and into the realm of quark–gluon plasmas. This motivates the quest for powerful and efficient computational methods that are able to accurately study fluid dynamics in the relativistic regime as well as the transition to beyond hydrodynamics—in principle all of the way down to ballistic regimes. We present a family of relativistic lattice kinetic schemes for the efficient simulation of relativistic flows in both strongly (fluid) and weakly (rarefied gas) interacting regimes. The method can deal with both massless and massive particles, thereby encompassing ultra- and mildly relativistic regimes alike. The computational performance of the method for the simulation of relativistic flows across the aforementioned regimes is discussed in detail, along with prospects of future applications

Synthetic approaches to a mononucleotide prodrug of cytarabine.

Synthetic pathways to a mononucleotide prodrug of cytarabine (Ara-C) bearing S-pivaloyl-2-thioethyl (tBuSATE) groups, as biolabile phosphate protections, are reported. Using a common phosphoramidite approach, two different kinds of nucleoside protecting groups have been investigated. During this study, we obsd. an intermol. migration of the Boc protecting group in the course of the tert-butyldimethylsilyl ether cleavage using tetra-Bu ammonium fluorid

Synthesis and antiproliferative activity of 2'-O-allyl-1-beta-D-arabynofuranosyl-uracil, -cytosine and -adenine

Functional modification at position 2' of nucleosides gave potent antiviral and antitumor compound

Synthesis and Biological Evaluation of a Series of Substituted Pyrazolo[3,4-d]-1,2,3-triazoles and Pyrazolo[3,4-d]oxazoles

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New isoxazole derivatives of retinoids: Synthesis and activity on growth and differentiation of tumor cells

The effects of several newly synthesized isoxazole analogues of retinoids on differentiation and proliferation of 'in vitro' cultured tumor cell lines are reported. Some of the tested compounds exhibit significative differentiating action, inducing adipogenic conversion of the Chinese hamster FH06T1-1 cell line in a range of 2-10 times the activity of retinoic acid and retinol

Enzymatic synthesis of 2’-O-acyl-prodrugs of 1-(beta-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (sorivudine, BV-araU) and of 2’-O-acyl-araU, -araC and -araA.

Pig liver esterase (EC 3.1.1.1) catalysed regioselective hydrolysis of 1-(2,3,5-tri-O-acyl-beta-D-arabinofuranosyl)uracil, -cytosine and -adenine to give the corresponding 2'-monoesters effectively and in high yield. This methodology enabled the preparation of 1-(2-O-acyl-beta-D-arabinofuranosyl)-5-[(E)-(2-bromovinyl)]uracil prodrugs which, although slightly less active than the parent 1-(beta-D-arabinofuranosyl)-5-(E)-(2 bromovinyl)uracil (sorivudine; BV-araU), were strongly active in vitro against varicella-zoster virus (ED50 2.4-45 ng/ml). The retarded rates of enzymatic hydrolysis of the 2'-esters imply that they might function as lipophilic prodrugs, leading to increased plasma and cellular concentrations. In view of the marked in vitro activity, they represent an interesting approach to arabinofuranosyl nucleoside prodrugs with improved pharmacokinetics and enzymatic stability

Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-a, Ara-c, 3(2H)-furanone, and aniline mustard moieties

In a dual targeting approach, to explore the ability of tretinoin (all-trans-retinoic acid) to behave as a covalent carrier for cytotoxic entities, conjugates of retinoic acid with a few representative molecules, being important examples of antitumor pharmacophores (i.e., nucleoside analogues and alkylating agents), have been synthesized and tested for their cytostatic and differentiating activity. All compounds were stable to in. vitro hydrolysis in human plasma and more lipophilic than the parent compounds, thus consenting enhanced uptake into the cells. Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides. Compound 3, endowed with a highly lipophilic silyl moiety at the 3' and 5' positions, showed the highest differentiating activity (54% and 44% differentiated HL-60 cells at 0.2 and 0.05 mu g/mL respectively). With regard to the retinoic acid conjugates of alkylating agents, compound 10 was the most cytostatic agent (IC50 < 0.32 mu g/mL) and the most potent differentiating agent (33-34% at 0;32 and 0.08 mu g/mL). These structures may also be regarded as analogs of either retinoic acid or the cytotoxic compound