Canonical Heroes Redefined for Postmodern Readership

The \u27hero\u27 has figured as an important archetypal construction throughout literary history that has evolved over centuries. Instead of tracing the evolution of the hero chronologically, this essay will present a postmodern reading of the hero in John Milton’s Paradise Lost and Homer’s Iliad by rereading those texts through James Joyce’s Ulysses. Through this retrospective reading, heroic construction comes to mean something different than it does to classicists or Romanticists. In his construction of Leopold Bloom as the everyman, modern hero, Joyce is unconcerned with physical strength, youth, honor, virtue, lineage, or glory. Rather, Joyce constructs Bloom as a hero with psychological and emotional depth, intellectual strength, and an identity in the domestic sphere; Bloom is constructed as Other from dominant culture and as a self-defined individual. This list of qualities, which implies that the hero is a man who functions in multiple, simultaneous roles, provides the definition of \u27hero\u27 that will be utilized throughout this paper

Critical Thinking Dispositions: The Need for a Balanced Curriculum in Collegiate Critical Thinking Courses

The aim of this synthesis is to argue that students cannot become effective thinkers simply by being taught the analytical skills of critical reading, writing, and thinking. Without learning the necessary dispositions of critical thinking students will not develop into well-rounded, effective thinkers. The study is focused on an already existing course at Mass Bay Community College. The present curriculum is based on the fundamental skills of determining the soundness and validity of an argument. Assisting and encouraging the obtainment of critical thinking dispositions will inspire students to become more aware of the role their listening and communicating skills and behaviors have on their ability to think effectively. As Kirby and Goodpaster assert, We have become what we have thought about and who we will become is limited by how and what we think (5). Dispositions are inclinations and habits of mind that benefit productive thinking (Tishman, Perkins, and Jay 1995, 37). Being open-minded, deferring judgment, listening to multiple perspectives, and having intellectual humility and intellectual curiosity are a few thinking dispositions that are presented in the discussion as well as in the proposed curriculum. Ennis, Paul, Tishman et al, all support the incorporation of thinking dispositions into critical thinking course curriculums. The curriculum presented in this synthesis is designed to engage students in thoughtful exploratory activities to help foster and cultivate dispositions required for effective thinking. The lesson plans are created with the intention of reinforcing students\u27 tendencies to transfer knowledge, utilize metacognitive strategies, and practice applying thinking dispositions in various scenarios and exercises. The curriculum utilizes critical thinking dispositions and incorporates the enhancement of listening, communicating, and behavioral skills. Each lesson includes a description of dispositions to be explored; an activity to encourage the fostering of those dispositions; goals and objectives; and attention to mental management and transfer of skills. The objective of incorporating nineteen dispositions into a pre-existing critical thinking curriculum is to help freshman college students become reasonable, reflective, and focused thinkers and decision-makers

Halogen Bonding Interactions of Haloaromatic Endocrine Disruptors and the Potential for Inhibition of Iodothyronine Deiodinases

Halogen bonding (XB) is a potential mechanism for the inhibition of the thyroid-activating/deactivating iodothyronine deiodinase family of selenoproteins through interactions with halogenated endocrine disrupting compounds (EDCs). Trends in XB interactions were examined using density functional theory for a series of polyhalogenated dibenzo-1,4-dioxins, biphenyls, and other EDCs with methylselenolate, a simple model of the Dio active site selenocysteine. The strengths of the interactions depend upon the halogen (Br\u3eCl), the degree of substitution, and the position of the acceptor. In terms of donor-acceptor energies, interactions at the meta position are often the strongest, suggesting a link to the topology of THs, especially for outer-ring deiodination of thyroxine, which occurs at a meta iodine, and produces the active TH. However, relationships between XB interaction strengths and potential for Dio inhibition should be made in the context of the binding to the active sites, the topology of which are not fully characterized

Theoretical Studies of 2,3 -Sigmatropic Rearrangements of Allylic Selenoxides and Selenimides

Density-functional theory is used to model the endo and exo transition states for [2,3]-sigmatropic rearrangement of allylic aryl-selenoxides and -selenimides. The endo transition state is generally preferred for selenoxides if there is no substitution at the 2 position of the allyl group. Based upon the relative energies of the endo and exo transition states, enantioselectivity of rearrangements is expected to be greatest for molecules with substitutions at the 1- or (E)-3- position of the allyl group. Ortho substitution of a nitro group on the ancillary selenoxide phenyl ring reduces the activation barriers, increases the difference between the endo and exo activation barriers and shifts the equilibrium toward products

The Effect of Metalation on Antimicrobial Piscidins Imbedded in Normal and Oxidized Lipid Bilayers

Metalation of the N-terminal Amino Terminal Cu(II)- and Ni(II)-binding (ATCUN) motif may enhance the antimicrobial properties of piscidins. Molecular dynamics simulations of free and nickelated piscidins 1 and 3 (P1 and P3) were performed in 3 : 1 POPC/POPG and 2.6 : 1 : 0.4 POPC/POPG/aldo-PC bilayers (POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine: POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol; aldo-PC, 1-palmitoyl-2-(9′-oxo-nonanoyl)-sn-glycero-3-phosphocholine) bilayer models. Nickel(II) binding decreases the conformation dynamics of the ATCUN motif and lowers the charge of the N-terminus to allow it to embed deeper in the bilayer without significantly changing the overall depth due to interactions of the charged half-helix of the peptide with the headgroups. Phe1⋯Ni2+ cation–π and Phe2–Phe1 CH–π interactions contribute to a small fraction of structures within the nickelated P1 simulations and may partially protect a bound metal from metal-centered chemical activity. The substitution of Phe2 for Ile2 in P3 sterically blocks conformations with cation–π interactions offering less protection to the metal. This difference between metalated P1 and P3 may indicate a mechanism by which peptide sequence can influence antimicrobial properties. Any loss of bilayer integrity due to chain reversal of the oxidized phospholipid chains of aldo-PC may be enhanced in the presence of metalated piscidins

A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity

Iodothyronine deiodinases (Dios) are involved in the regioselective removal of iodine from thyroid hormones (THs). Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site has been proposed to contribute to the mechanism for iodine removal. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known disruptors of various pathways of the endocrine system. Experimental evidence shows PBDEs and their hydroxylated metabolites (OH-BDEs) can inhibit Dio, while data regarding PCB inhibition are limited. These xenobiotics could inhibit Dio activity by competitively binding to the active site Sec through XB to prevent deiodination. XB interactions calculated using density functional theory (DFT) of THs, PBDEs, and PCBs to a methyl selenolate (MeSe-) arrange XB strengths in the order THs \u3e PBDEs \u3e PCBs in agreement with known XB trends. THs have the lowest energy C–X*-type unoccupied orbitals and overlap with the Se lp donor leads to high donor-acceptor energies and the greatest activation of the C–X bond. The higher energy C–Br* and C–Cl* orbitals similarly result in weaker donor-acceptor complexes and less activation of the C–X bond. Comparison of the I...Se interactions for the TH group suggest that a threshold XB strength may be required for dehalogenation. Only highly brominated PBDEs have binding energies in the same range as THs, suggesting that these compounds may inhibit Dio and undergo debromination. While these small models provide insight on the I...Se XB interaction itself, interactions with other active site residues are governed by regioselective preferences observed in Dios

Effect of Methoxy Substituents on the Activation Barriers of the Glutathione Peroxidase-Like Mechanism of an Aromatic Cyclic Seleninate

Density functional theory (DFT) models including explicit water molecules have been used to model the redox scavenging mechanism of aromatic cyclic seleninates. Experimental studies have shown that methoxy substitutions affect the rate of scavenging of reactive oxygen species differently depending upon the position. Activities are enhanced in the para position, unaffected in the meta, and decreased in the ortho. DFT calculations show that the activation barrier for the oxidation of the selenenyl sulfide, a proposed key intermediate, is higher for the ortho methoxy derivative than for other positions, consistent with the low experimental conversion rate

Sailfish (Istiophorus platypterus) Habitat Utilization in the Southern Gulf of Mexico and Florida Straits with Implications on Vulnerability to Shallow-Set Pelagic Longline Gear

A total of 19 pop-up satellite archival tags (PSATs) were deployed on sailfish in the southern Gulf of Mexico between 2005 and 2007 aboard a commercial pelagic longline vessel (n = 18) and a recreational rod-and-reel vessel (n = 1). All PSATs were programmed to collect pressure (depth), temperature, and light-level data for 10 days at approximately 90-second intervals. These point-level data were not summarized prior to transmission, allowing the reconstruction of vertical movement patterns. Three tags suggested mortality events and were excluded from subsequent analyses. We present the preliminary data analyses from the remaining 16 PSATs. Sailfish are primarily associated with the upper surface waters at 20 m or less depth. However, sailfish also exhibited numerous repeated short-duration vertical movements below the local thermocline to depths of 50-150 m. The depth utilization from these tagged fish coincide with the actively fished depths of shallow-set pelagic longline gear, yet appear to be shallower than the depths of settled deep-set gear used to target bigeye tuna