A Case of Angiolymphoid Hyperplasia with Eosinophilia Aggravated During Pregnancy

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon and benign vascular disorder characterized by angiomatous, pink-red papulonodular lesions mainly located on the scalp, neck, and periauricular region. Although the exact cause of ALHE is unknown, several etiologic factors including insect bites or parasites, trauma, hyperestrogen states, and immunologic factors have been implicated in the pathogenesis of the disease. Only a few cases of pregnancy related ALHE so far have been reported in the literature. In this article, we report a case of ALHE with postauricular location aggravated during the first trimester of pregnancy

A Recurrent Mutation in the ARS (Component B) Gene Encoding SLURP-1 in Turkish Families with Mal de Meleda: Evidence of a Founder Effect

6 páginas, 2 figuras.Mal de Meleda is a rare form of palmoplantar keratoderma, and recently mutations in the ARS (component) B gene have been identified in families with this disease. We identified a recurrent nonsense mutation, R96X, in four families of Turkish descent. In this report, we demonstrate that these families share a common ancestral haplotype at the mal de Meleda locus, suggesting a founder effect.This work was supported in part by the Dermatology Foundation (J.T.C.), the Waterbor Burn and Cancer Foundation (J.T.C.), the Irving Center for Clinical Research at Columbia University (J.T.C.), and USPHS NIH RO1AR44924 (A.M.C.).Peer reviewe