Comparative evaluation of the drug metabolising activity of rat, dog and humanc hepatocytes using two model substrates and loxtidine

SIGLEAvailable from British Library Document Supply Centre- DSC:DX97186 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Dissecting a 30 kpc galactic outflow at z ∼ 1.7

We present the spatially resolved measurements of a cool galactic outflow in the gravitationally lensed galaxy RCS0327 at z ≈ 1.703 using VLT/MUSE IFU observations. We probe the cool outflowing gas, traced by blueshifted Mg II and Fe II absorption lines, in 15 distinct regions of the same galaxy in its image-plane. Different physical regions, 5 – 7 kpc apart within the galaxy, drive the outflows at different velocities (Vout ∼ −161 to −240 km s−1), and mass outflow rates (Ṁout ∼ 183 – 527 M yr−1). The outflow velocities from different regions of the same galaxy vary by 80 km s−1, which is comparable to the variation seen in a large sample of star-burst galaxies in the local universe. Using multiply lensed images of RCS0327, we probe the same star-forming region at different spatial scales (0.5–25 kpc2), we find that outflow velocities vary between ∼ −120 and −242 km s−1, and the mass outflow rates vary between ∼37 and 254 M yr−1. The outflow momentum flux in this galaxy is ≥ 100% of the momentum flux provided by star formation in individual regions, and outflow energy flux is ≈ 10% of the total energy flux provided by star formation. These estimates suggest that the outflow in RCS0327 is energy driven. This work shows the importance of small scale variations of outflow properties due to the variations of local stellar properties of the host galaxy in the context of galaxy evolution. © The Author(s) 2023.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

SMOC1 is a glucose-responsive hepatokine and therapeutic target for glycemic control

Intertissue communication is a fundamental feature of metabolic regulation, and the liver is central to this process. We have identified sparc-related modular calcium-binding protein 1 (SMOC1) as a glucose-responsive hepatokine and regulator of glucose homeostasis. Acute intraperitoneal administration of SMOC1 improved glycemic control and insulin sensitivity in mice without changes in insulin secretion. SMOC1 exerted its favorable glycemic effects by inhibiting adenosine 3',5'-cyclic monophosphate (cAMP)-cAMP-dependent protein kinase (PKA)-cAMP response element-binding protein (CREB) signaling in the liver, leading to decreased gluconeogenic gene expression and suppression of hepatic glucose output. Overexpression of SMOC1 in the liver or once-weekly intraperitoneal injections of a stabilized SMOC1-FC fusion protein induced durable improvements in glucose tolerance and insulin sensitivity in db/db mice, without adverse effects on adiposity, liver histopathology, or inflammation. Furthermore, circulating SMOC1 correlated with hepatic and systemic insulin sensitivity and was decreased in obese, insulin-resistant humans. Together, these findings identify SMOC1 as a potential pharmacological target for the management of glycemic control in type 2 diabetes.Magdalene K. Montgomery, Jacqueline Bayliss, Camille Devereux, Ayenachew Bezawork-Geleta ... Scott L. Townley, Luke A. Selth ... et al

Spatial Variation in Strong Line Ratios and Physical Conditions in Two Strongly Lensed Galaxies at z ∼ 1.4

Upcoming space-based integral field spectrographs will enable spatially resolved spectroscopy of distant galaxies, including at the scale of individual star-forming regions (i.e., down to just tens of parsecs) in galaxies that have been strongly gravitationally lensed. In the meantime, there is only a very small set of lensed galaxies where such spatial detail is possible at wavelengths containing important rest-optical emission lines, even with the Hubble Space Telescope's Wide Field Camera 3 infrared channel grisms. Here, we examine two of these sources, SDSS J1723+3411 and SDSS J2340+2947, using HST WFC3/IR grism data and supporting spatially unresolved spectroscopy from several ground-based instruments to explore the size of spatial variations in observed strong emission-line ratios like O32 and R23, which are sensitive to ionization parameter and metallicity, and the Balmer decrement, which is an indicator of reddening. We find significant spatial variation in the reddening and in the reddening-corrected O32 and R23 values that correspond to spreads of a few tenths of a dex in ionization parameter and metallicity. We also find clear evidence of a negative radial gradient in star formation in SDSS J2340+2947 and tentative evidence of one in SDSS J1723+3411, though its star formation is quite asymmetric. Finally, we find that reddening can vary enough spatially to make spatially resolved reddening corrections necessary in order to characterize gradients in line ratios and the physical conditions inferred from them, necessitating the use of space-based integral field units for future work on larger, more statistically robust samples. © 2021. The American Astronomical Society. All rights reserved..Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Late Iron Age longhouse chronology. A study aimed at constructing a formal house chronology for the Late Iron Age, based on selected localities in central and eastern Jutland

This paper presents a formalised chronological study of the longhouses of the Late Iron Age. This is based on the correspondence analysis of data relating to house ground plans recorded at a number of Iron Age settlements in central and eastern Jutland, which, as a region, has the most comprehensive relevant data set, including many constructional details. The chronology constitutes a formalisation of the house-chronological considerations undertaken to date in reference to settlements in Jutland and results in a seriable sequence, the chronological significance of which is supported by stratigraphic observations. The study demonstrates that, in general, the investigated settlements follow the same chronological development and can therefore be correlated. Moreover, it shows that the placing of each individual house in the chronology is subject to some uncertainty, due to the relatively small number and long duration of the chronological features