487 research outputs found
La clase en regresión: racismo lingüístico y malas praxis educativas en la educación estadounidense
Darder’s depiction of “Linguistic Racialization”, described herein, provides the foundation for this discussion, where raciolinguistic pedagogy has perpetuated a diverse and troubling legacy of educational malpractice against underrepresented language minority students who attend underresourced public schools throughout America. Due, in part, to paradoxical educational practices with differential access to unequal educational resources, the vast majority of linguistically disenfranchised students are often overlooked, or worse, subjected to misguided educational practices that fail to reduce academic disparities that are reinforced by poverty, unequal access to fair housing, and a lack of pedagogical dexterity that might have the potential to promote improved educational outcomes. Some policy proposals conclude this discussion, which, if implemented, could potentially overcome the history of unequal academic achievement that has resulted from a combination of De Jure and De Facto educational apartheid.El panorama que traza Darder de la “racialización lingüística”, descrito aquí, ofrece la base de esta discusión, donde la pedagogía raciolingüística ha perpetuado un legado diverso y preocupante de malas praxis educativas hacia estudiantes infrarrepresentados de minorías lingüísticas que asisten a escuelas públicas infradotadas en los Estados Unidos. Debido, en parte, a prácticas educativas paradójicas con un acceso diferencial a recursos educativos desiguales, la gran mayoría de estudiantes privados de derechos lingüísticos son a menudo ignorados, o aún peor, están sujetos a prácticas educativas erróneas que no logran reducir las desigualdades académicas, reforzadas por la pobreza, el acceso desigual a una vivienda digna y la ausencia de destrezas pedagógicas que dispondrían del potencial de promover mejores resultados educativos. Esta discusión concluye con algunas propuestas sobre política educativa que, en caso de implementarse, podrían superar potencialmente la historia de logros académicos desiguales que ha resultado de una combinación de un apartheid educativo de iure y de facto
Enhancing Cache Robustness in Named Data Networks
Information-centric networks (ICNs) are a category of network architectures that focus on content, rather than hosts, to more effectively support the needs of today’s users. One major feature of such networks is in-network storage, which is realized by the presence of content storage routers throughout the network. These content storage routers cache popular content object chunks close to the consumers who request them in order to reduce latency for those end users and to decrease overall network congestion. Because of their prominence, network storage devices such as content storage routers will undoubtedly be major targets for malicious users. Two primary goals of attackers are to increase cache pollution and decrease hit rate by legitimate users. This would effectively reduce or eliminate the advantages of having in-network storage. Therefore, it is crucial to defend against these types of attacks. In this thesis, we study a specific ICN architecture called Named Data Networking (NDN) and simulate several attack scenarios on different network topologies to ascertain the effectiveness of different cache replacement algorithms, such as LRU and LFU (specifically, LFU-DA.) We apply our new per-face popularity with dynamic aging (PFP-DA) scheme to the content storage routers in the network and measure both cache pollution percentages as well as hit rate experienced by legitimate consumers. The current solutions in the literature that relate to reducing the effects of cache pollution largely focus on detection of attacker behavior. Since this behavior is very unpredictable, it is not guaranteed that any detection mechanisms will work well if the attackers employ smart attacks. Furthermore, current solutions do not consider the effects of a particularly aggressive attack against any single or small set of faces (interfaces.) Therefore, we have developed three related algorithms, namely PFP, PFP-DA, and Parameterized PFP-DA. PFP ensures that interests that ingress over any given face do not overwhelm the calculated popularity of a content object chunk. PFP normalizes the ranks on all faces and uses the collective contributions of these faces to determine the overall popularity, which in turn determines what content stays in the cache and what is evicted. PFP-DA adds recency to the original PFP algorithm and ensures that content object chunks do not remain in the cache longer than their true, current popularity dictates. Finally, we explore PFP-β, a parameterized version of PFP-DA, in which a β parameter is provided that causes the popularity calculations to take on Zipf-like characteristics, which in turn reduces the numeric distance between top rated items, and lower rated items, favoring items with multi-face contribution over those with single-face contributions and those with contributions over very few faces. We explore how the PFP-based schemes can reduce impact of contributions over any given face or small number of faces on an NDN content storage router. This in turn, reduces the impact that even some of the most aggressive attackers can have when they overwhelm one or a few faces, by normalizing the contributions across all contributing faces for a given content object chunk. During attack scenarios, we conclude that PFP-DA performs better than both LRU and LFU-DA in terms of resisting the effects of cache pollution and maintaining strong hit rates. We also demonstrate that PFP-DA performs better even when no attacks are being leveraged against the content store. This opens the door for further research both within and outside of ICN-based architectures as a means to enhance security and overall performance.Ph.D.College of Engineering & Computer ScienceUniversity of Michigan-Dearbornhttps://deepblue.lib.umich.edu/bitstream/2027.42/145175/1/John Baugh Final Dissertation.pdfDescription of John Baugh Final Dissertation.pdf : Dissertatio
Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis
Fibrosis is a progressive and potentially fatal process that can occur in numerous organ systems. Characterised by the excessive deposition of extracellular matrix proteins such as collagens and fibronectin, fibrosis affects normal tissue architecture and impedes organ function. Although a considerable amount of research has focused on the mechanisms underlying disease pathogenesis, current therapeutic options do not directly target the pro-fibrotic process. As a result, there is a clear unmet clinical need to develop new agents. Novel findings implicate a role for epigenetic modifications contributing to the progression of fibrosis by alteration of gene expression profiles. This review will focus on DNA methylation; its association with fibroblast differentiation and activation and the consequent buildup of fibrotic scar tissue. The potential use of therapies that modulate this epigenetic pathway for the treatment of fibrosis in several organ systems is also discussed
GALES (Reino Unido). Mapas generales (1795). 1:80000
Comprende desde la bahía Cardigan hasta la costa septentrional del Pais de GalesEscala gráfica de 6 millas estatutarias [= 12 cm]. Coordenadas referidas a un meridiano que no se especifica, probablemente Londres o Greenwich (E 5°15'--E 2°49'/N 53°24'--N 52°19'). Orientado con flechaOrografía por normalesLímites entre los condados diferenciados por coloresDedicatoria y título decorados con un grabado que representa las ruinas de una iglesi
Downscaling Storm Surge Models for Engineering Applications
Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv
Differential regulation of monocyte cytokine release
SIGLEAvailable from British Library Document Supply Centre-DSC:DXN025329 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Cardiomyopathy in Offspring of Pregestational Diabetic Mouse Pregnancy
Purpose. To investigate cardiomyopathy in offspring in a mouse model of pregestational type 1 diabetic pregnancy. Methods. Pregestational diabetes was induced with STZ administration in female C57BL6/J mice that were subsequently mated with healthy C57BL6/J males. Offspring were sacrificed at embryonic day 18.5 and 6-week adolescent and 12-week adult stages. The size and number of cardiomyocyte nuclei and also the extent of collagen deposition within the hearts of diabetic and control offspring were assessed following cardiac tissue staining with either haematoxylin and eosin or Picrosirius red and subsequently quantified using automated digital image analysis. Results. Offspring from diabetic mice at embryonic day 18.5 had a significantly higher number of cardiomyocyte nuclei present compared to controls. These nuclei were also significantly smaller than controls. Collagen deposition was shown to be significantly increased in the hearts of diabetic offspring at the same age. No significant differences were found between the groups at 6 and 12 weeks. Conclusions. Our results from offspring of type 1 diabetic mice show increased myocardial collagen deposition in late gestation and have increased myocardial nuclear counts (hyperplasia) as opposed to increased myocardial nuclear size (hypertrophy) in late gestation. These changes normalize postpartum after removal from the maternal intrauterine environment
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