Single Nucleotide Polymorphisms (SNPs) in fibronectin binding protein B (<i>fnbB)</i> in <i>fnbB-</i>containing isolates.

<p>*When false discovery rate control is applied, this raw p-value no longer maintains statistical significance (p = 1.00).</p><p>No SNP was associated with the prosthetic joint infected (PJI) or uninfected (PJU) isolates in the derivation cohort, external validation cohort, or late <i>S</i>. <i>aureus</i> bacteremia (SAB) group. Late SAB was defined as SAB occurring >1 year after placement or manipulation of prostheses.</p

Comparison of the biofilm-forming capacity of <i>S</i>. <i>aureus</i> isolates from prosthetic joint infection (PJI) and uninfected prosthetic joint (PJU) groups.

<p>Values were calculated as percentage capacity to form biofilms relative to <i>S</i>. <i>aureus</i> control strain UAMS-1. Box ends represent the 25^th and 75^th percentiles, and whisker ends represent the minimum and maximum. There was no difference in biofilm-forming capacity between isolates in the PJI and PJU groups.</p

Demographic and clinical characteristics of patients in the derivation cohort with <i>S</i>. <i>aureus</i> bacteremia and infected or uninfected prostheses.

<p>*Late infection is defined as bloodstream infection occurring >1 year after the prostheses was implanted or surgically manipulated.</p><p>Demographic and clinical characteristics of patients in the derivation cohort with <i>S</i>. <i>aureus</i> bacteremia and infected or uninfected prostheses.</p

Single Nucleotide Polymorphisms (SNPs) in fibronectin binding protein A (<i>fnbA)</i> in the derivation cohort, external validation cohort, and late <i>S</i>. <i>aureus</i> bacteremia (SAB) group.

<p>*When false discovery rate control is applied, this raw p-value no longer maintains statistical significance (p = 0.22).</p><p>In the derivation cohort, no SNPs occurred with greater frequency in the prosthetic joint infection group (PJI) relative to the uninfected prosthetic joint group (PJU). In the external validation cohort, one SNP (S839N) was significantly associated with the PJU group, though when the two cohorts were combined the S839N association did not reach statistical significance (p = 0.22). Late SAB was defined as bacteremia occurring >1 year after placement or manipulation of prostheses, and here contains data from both the derivation and external validation cohorts. In the late SAB group, no SNPs occurred with greater frequency in PJI or PJU.</p

Comparison of the fibronectin binding capacity of <i>S</i>. <i>aureus</i> isolates from prosthetic joint infection (PJI) and uninfected prosthetic joint (PJU) groups.

<p>Values were calculated as percentage capacity to bind fibronectin relative to <i>S</i>. <i>aureus</i> control strain 8325–4. Box ends represent the 25^th and 75^th percentiles, and whisker ends represent the minimum and maximum. There was no difference in fibronectin binding capacity between isolates in the PJI and PJU groups.</p

Single Nucleotide Polymorphisms (SNPs) in the binding regions (Repeats 1–11) of fibronectin binding protein B (FnBPB) in the derivation cohort (A) and the external validation cohort (B).

<p>Red boxes indicate SNPs that were only present in isolates from the prosthetic joint infection group (PJI), blue boxes indicate SNPs that were only present in the uninfected (PJU) group, and purple boxes indicate SNPs that were present in both PJI and PJU isolates.</p