Regional development and banking activities

This article is a continuation of studies devoted to the interaction of the region and its banking system. The research object in this article is the banking system of the Rostov region, the Southern Federal District, and its impact on the acceleration of socioeconomic development of both the regions. The subject of the study is interaction of banks with the real sector of the economy and the population of the region. The authors analyzed the scientific sources exploring the interaction of the banking and real sectors of the economy and methodological approaches to the analysis of banking activities’s effects on the region and its socio-economic indicators. Based on econometric modeling, quantitative and qualitative regularities of the indicators are revealed. As a result, authors concluded that the growth in the total volume of profits received by existing credit institutions contributes to the growth of such important socio-economic indicators like Gross Regional Product, internal costs of research and development, labor productivity, fixed asset investments, per capita income, growth of deposits attracted by credit institutions, as well as the growth in the amount of debt on loans extended by credit institutions to legal entities and individuals.peer-reviewe

Pharmacological preconditioning by incretinomimetics exenatide and vildagliptin: decrement of liver ischemia-reperfusion injury

Study of hepatoprotective activity of exenatide and vildagliptin on the liver ischemia/reperfusion model, taking into account biochemical and morphological parameter

Characteristics of blood pressure level in children with different body weight

BACKGROUND: Essential arterial hypertension (AH) develops more often in children with accompanying risk factors — obesity, overweight, positive heredity and genetic predisposition.AIM: Study of peculiarities of arterial hypertension clinical course in adolescents with normal body weight, overweight and obesity.MATERIALS AND METHODS: The study was conducted on children with arterial hypertension who received treatment in two hospitals in Voronezh in 2016–2020. A retrospective analysis of the children’s case histories was carried out taking into account the anamnesis, clinical laboratory and instrumental examination data and the pharmacotherapy. Some children underwent polymerase chain reaction genetic testing to determine pathological alleles of genes regulating blood pressure (BP).RESULTS: 96 patients aged 9 to 17 took part in the study. The group with normal body weight included 38 children (39.6%), median age 16.4 (aged 10.7; 17.9), with overweight — 33 people (34.4%), median age 15.2 (aged 12.0; 17.9), with obesity — 25 children (26.0%), median age 14.5 (aged 9.2; 17.9). Obese children developed arterial hypertension at earlier age (p = 0.023). According to blood pressure daily monitoring (BPDM), pathological values of systolic blood pressure (SBP) during the day (above the 95th percentile) among children with normal body weight were observed in 17 patients (44.7%), with excess body weight — in 14 people (42.4%), with obesity — in 16 people (64%), p = 0.031. Accurate difference values between the groups were obtained in terms of time index (TI) of SBP at night (p = 0.006). Time index of diastolic BP during the day > 50% was observed only in the obese children group — 4 people (16%) (p = 0.042). Pathological alleles of the angiotensinogen gene (AGT: 704 T>C), aldosterone synthase gene (CYP11B2: -344 C>T) and endothelial nitrogen synthase type 3 (NOS3: -786 T> C) were identified most frequently during genetic testing in some patients.CONCLUSION: Children with obesity developed earlier arterial hypertension compared to the same-age children with normal body weight and more often had unfavorable type of arterial hypertension according to BPDM. These results can be used to choose individual therapy and to develop special attention as regards certain target organs damage

Репарация легочной ткани при впервые выявленном туберкулезе легких как генетически детерминированный процесс

The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy.Цель исследования: оценить влияние полиморфизма rs6707530 гена FN1 и полиморфизма rs1150754 гена TNXB на динамику заживления деструкции легочной ткани у больных с впервые выявленным туберкулезом легких.Материалы и методы. В исследование включено 82 пациента старше 18 лет с впервые выявленным туберкулезом легких в фазе распада. На 2, 4 и 6-м мес. исследования проводилась оценка рентгенологических данных. Пациенты были разделены на 2 группы в зависимости от эффективности интенсивной фазы химиотерапии.Результаты. В группе пациентов с эффективным курсом химиотерапии чаще встречались носители аллеля G (p < 0,001) и генотипа T/G (p = 0,01) в локусе rs6707530 гена FN1. При этом генотип T/T (p = 0,002) и аллель Т (p < 0,001) доминировали среди пациентов с сохранением деструкции легочной ткани после интенсивной фазы химиотерапии

Investigation of drop geometry at free-falling process depending on volume of dozing

Present work performs experimental investigation of the changes in the geometric shape of the drop in terms of its free-falling, depending on the conditions of drop formation on dispenser. It was found that volume and velocity of drop formation on dispenser are the factors affecting the geometric shape of the drop in terms of its free-falling

Reparation of lung tissue in newly detected pulmonary tuberculosis as genetically determined process

The objective of the study is to assess the effect of rs6707530 polymorphism of the FN1 gene and rs1150754 polymorphism of the TNXB gene on the healing of lung tissue destruction in patients with newly detected pulmonary tuberculosis.Subjects and methods. 82 patients older 18 years with newly diagnosed pulmonary tuberculosis with destruction were enrolled in the study. X-ray data were assessed on the 2nd, 4th and 6th months of the study. Patients were divided into 2 groups depending on the efficacy of chemotherapy intensive phase.Results. In the group of patients with an effective course of chemotherapy, the frequency of carriers of G allele (p < 0.001) and T/G genotype (p = 0.01) in rs6707530 locus of the FN1 gene was higher. While T/T genotype (p = 0.002) and T allele (p < 0.001) prevailed among the patients with persisting destruction of lung tissue after the intensive phase of chemotherapy

The influence of non-selective arginase inhibitors on some reparative regeneration indexes of experimentally resected liver

The impact of L-norvaline, a non-selective arginase inhibitor, on the state of the resected liver of Wistar strain white male rat, was evaluated. The resection of the liver was made on the second day of the experiment to the extent of 70%. L-norvaline (“WIRUD JmgH”, Hamburg) was intragastrically administered, at a daily dose of 18mg/kg for the first seven days of the experiment, every 48 hour