Utilisation de la toxine botulique dans le traitement des paralysies faciales (enquête auprès des patients)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Atalante research facility implementation of a rule of fractions for the management of reflecting materials in mass-limited units

International audienceATALANTE,located in Marcoule,is one of the main Nuclear Facilities of the French CEA.In terms of criticality risk prevention, the facility is divided into work units mostly managed through a mass control mode.The limit authorized is 350 g of fissile materialwith 239Pu-H2O as reference fissile medium. This mass limit was determined considering a reflectionby 20 cm of water.Under these conditions, some neutronic reflectors, which are more efficient than watercan be authorized only in limited quantities. In ATALANTEthe reflecting materials identified as requiring a specific management are lead, uranium (235U/Utotal = 1%), graphite, heavy water and beryllium.Initiallya maximum permissible mass was determined for each of these materials taken separately. However, this method requires that when different reflectors are present simultaneouslythe sum of the masses of all these reflectors must be less than the limit specified for the most penalizing of them.This rule has proved to impose too many re-strictions on the operator.A new rule has therefore been implemented:the rule of fractions.To demonstrate that this rule is acceptable, criticality calculations have been performed. The geometric configurations studied are a sphere of 350 g of 239Pu moderated by water and re-flected by various masses of 2 to 6 reflectors (successions of concentric shells) followed by 20 cm of water.It has been concluded that compliance with the new rule makes it possible to ensurecriticality safety in the case of the simultaneous presence of different reflectors

Effect of intra-articular Botulinum toxin injections on temporo-mandibular joint pain

International audienceTemporo-mandibular joint dysfunction can be painful and disabling. In some cases, it is refractory to classical treatment. Intra-articular Botulinum toxin injections have been shown to have an anti-inflammatory and analgesic effect. The aim of this study was to evaluate the effectiveness of such injections on severe, refractory temporo-mandibular joint pain. This was a retrospective study. Patients were included if they still had joint pain≥5 on a Visual Analogue Scale following completion of all other treatments. A complete treatment protocol (including physiotherapy, tongue splints, intra muscular injections of Botulinum toxin and injections of hyaluronic acid, excluding surgery) having being done before the injection of 30 Botox* units (Botulinum toxin A), the treatment being considered clinically successful if the Visual Analogue Scale decreases by at least 2 points. Seventy-seven patients were included. Sixty-six percent of patients have a significant reduction in pain at 1 month which lasted at least until 3 months. Mouth opening and quality of life also improved. Moreover, no complications were reported. Further randomized, controlled studies are needed to confirm the results, however this study suggests intra-articular injection of Botulinum toxin is a safe and effective treatment for severe, refractory temporo-mandibular joint pain, avoiding surgery