Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement

Líquido cefalorraquídeo; Consenso; Esclerosis múltipleLíquid cefaloraquidi; Consens; Esclerosi múltipleCerebrospinal fluid; Consensus; Multiple sclerosisCerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. The gold standard to determine intrathecal IgG synthesis is the detection of CSF-restricted oligoclonal bands (OCBs). However, advances in laboratory methods brought up κ-free light chains (FLCs) as a new biomarker, which are produced in excess over intact immunoglobulins and accumulate in CSF in the case of central nervous system-derived inflammation. Overwhelming evidence showed a high diagnostic accuracy of intrathecal κ-FLC synthesis in MS with sensitivity and specificity of approximately 90% similar to OCB. κ-FLCs have advantages as its detection is fast, easy, cost-effective, reliable, rater-independent and returning quantitative results which might also improve the value of predicting MS disease activity. An international panel of experts in MS and CSF diagnostics developed a consensus of all participants. Six recommendations are given for establishing standard CSF evaluation in patients suspected of having MS. The panel recommended to include intrathecal κ-FLC synthesis in the next revision of MS diagnostic criteria as an additional tool to measure intrathecal immunoglobulin synthesis

Azimuthal anisotropy and correlations in p+p, d+Au and Au+Au collisions at 200 GeV

We present the first measurement of directed flow ($v_1$) at RHIC. $v_1$ is found to be consistent with zero at pseudorapidities $\eta$ from -1.2 to 1.2, then rises to the level of a couple of percent over the range $2.4 < |\eta| < 4$. The latter observation is similar to data from NA49 if the SPS rapidities are shifted by the difference in beam rapidity between RHIC and SPS. Back-to-back jets emitted out-of-plane are found to be suppressed more if compared to those emitted in-plane, which is consistent with {\it jet quenching}. Using the scalar product method, we systematically compared azimuthal correlations from p+p, d+Au and Au+Au collisions. Flow and non-flow from these three different collision systems are discussed.Comment: Quark Matter 2004 proceeding, 4 pages, 3 figure

Azimuthal anisotropy: the higher harmonics

We report the first observations of the fourth harmonic (v_4) in the azimuthal distribution of particles at RHIC. The measurement was done taking advantage of the large elliptic flow generated at RHIC. The integrated v_4 is about a factor of 10 smaller than v_2. For the sixth (v_6) and eighth (v_8) harmonics upper limits on the magnitudes are reported.Comment: 4 pages, 6 figures, contribution to the Quark Matter 2004 proceeding

Correlations and Fluctuations in STAR

We report measurements for the balance function, transverse momentum fluctuations, and net charge fluctuations from Au+Au collisions at 20, 130, and 200 GeV as well as p+p and d+Au collisions at 200 GeV using STAR at RHIC. For Au+Au collisions at 200 GeV, we observe a narrowing of the balance function in central collisions. We observe dynamic transverse momentum fluctuations at all incident energies. Observables related to transverse momentum fluctuations and net charge fluctuations are similar for peripheral Au+Au collisions and inclusive p+p collisions while central Au+Au collisions deviate significantly from HIJING predictions.Comment: 4 pages, 3 figures, Contribution to Quark Matter 2004 Proceeding

All-optical switching and strong coupling using tunable whispering-gallery-mode microresonators

We review our recent work on tunable, ultrahigh quality factor whispering-gallery-mode bottle microresonators and highlight their applications in nonlinear optics and in quantum optics experiments. Our resonators combine ultra-high quality factors of up to Q = 3.6 \times 10^8, a small mode volume, and near-lossless fiber coupling, with a simple and customizable mode structure enabling full tunability. We study, theoretically and experimentally, nonlinear all-optical switching via the Kerr effect when the resonator is operated in an add-drop configuration. This allows us to optically route a single-wavelength cw optical signal between two fiber ports with high efficiency. Finally, we report on progress towards strong coupling of single rubidium atoms to an ultra-high Q mode of an actively stabilized bottle microresonator.Comment: 20 pages, 24 figures. Accepted for publication in Applied Physics B. Changes according to referee suggestions: minor corrections to some figures and captions, clarification of some points in the text, added references, added new paragraph with results on atom-resonator interactio

Strange Resonance Production in p+p and Au+Au Collisions at RHIC Energies

Resonance yields and spectra from elementary p+p and Au+Au collisions at $\sqrt{s_{\rm NN}} =$ 200 GeV from the STAR experiment at RHIC are presented and discussed in terms of chemical and thermal freeze-out conditions. Thermal models do not adequately describe the yields of the resonance production in central Au+Au collisions. The approach to include elastic hadronic interactions between chemical freeze-out and thermal freeze-out suggests a time of $\Delta \tau>$5 fm/c.Comment: 4 pages, 7 figures, proceedings of the Quark Matter 2004, in Oakland, California, to be published in Journal of Physics G: Nuclear and Particle Physic

Identified particles at large transverse momenta in STAR in Au+Au collisions @ sqrt(s_NN) = 200 GeV

We report measurements of the ratios of identified hadrons (pi,K,p,Lambda) in Au+Au collisions at sqrt(s_NN) = 200 GeV as a function of both collision centrality and transverse momentum (p_T). Ratios of anti-baryon to baryon yields are independent of p_T within 2<p_T <6 GeV/c indicating that, for such a range, our measurements are inconsistent with theoretical pQCD calculations predicting a decrease due to a stronger contribution from valence quark scattering. For both strange and non-strange species, a strong baryon enhancement relative to meson yields is observed as a function of collision centrality in this intermediate p_T region, leading to p/pi and Lambda/K ratios greater than unity. The nuclear modification factor, R_cp (central relative to peripheral collisions), is used to illustrate the interplay between jet quenching and hadron production. The physics implications of these measurements are discussed with reference to different theoretical models.Comment: 5 pages, 4 figures. Proceedings of Quark Matter 2004 Conference, Jan 2004, Oakland, USA. Submitted to Journal of Physics

High-pTp_{T} electron distributions in d+Au and p+p collisions at RHIC

We present preliminary measurements of electron and positron spectra in d+Au and p+p collisions at $\sqrt{s_{NN}}=200$ GeV for $1.5 < p_{T} < 7.0$ GeV/c. These measurements were carried out using the STAR Time Projection Chamber (TPC) and the Barrel Electromagnetic calorimeter (EMC). Overall hadron rejection factors in the range of $10^{5}$ have been achieved. In this work we describe the measurement technique used to discriminate electrons from hadrons and compare the results for single electron spectra with Pythia based pQCD calculations for electrons from heavy-quark semi-leptonic decays.Comment: Quark Matter 2004 conference proceeding

Measurement of open charm production in dd+Au collisions at sNN\sqrt{s_{NN}}=200 GeV

We present the first comprehensive measurement of $D^{0}, D^{+}, D^{*+}$ and their charge conjugate states at mid-rapidity in $d$+Au collisions at $\sqrt{s_{_{NN}}}$=200 GeV using the STAR TPC. The directly measured open charm multiplicity distribution covers a broad transverse momentum region of 0$<p_{T}<11$ GeV/$c$. The measured $dN/dy$ at mid-rapidity for $D^{0}$ is $0.0265\pm 0.0036 (stat.) \pm 0.0071 (syst.)$ and the measured $D^{*+}/D^{0}$ and $D^{+}/D^{0}$ ratios are approximately equal with a magnitude of $0.40\pm 0.09(stat.) \pm 0.13(syst.)$. The total $c\bar{c}$ cross section per nucleon-nucleon collision extracted from this study is $1.18 \pm 0.21(stat.) \pm 0.39(syst.)$mb. The direct measurement of open charm production is consistent with STAR single electron data. This cross section is higher than expectations from PYTHIA and other pQCD calculations. The measured $p_{T}$ distribution is harder than the pQCD prediction using the Peterson fragmentation function.Comment: Quark Matter 2004 Proceeding

Wind modelling of very massive stars up to 300 solar masses

Some studies have claimed a universal stellar upper-mass limit of 150 Msun. A factor that is often overlooked is that there might be a difference between the current and initial masses of the most massive stars, as a result of mass loss. We present Monte Carlo mass-loss predictions for very massive stars in the range 40-300 Msun, with large luminosities and Eddington factors Gamma. Using our new dynamical approach, we find an upturn in the mass-loss vs. Gamma dependence, at the point where the winds become optically thick. This coincides with the location where wind efficiency numbers surpass the single-scattering limit of Eta = 1, reaching values up to Eta = 2.5. Our modelling suggests a transition from common O-type winds to Wolf-Rayet characteristics at the point where the winds become optically thick. This transitional behaviour is also revealed with respect to the wind acceleration parameter beta, which starts at values below 1 for the optically thin O-stars, and naturally reaches values as high as 1.5-2 for the optically thick Wolf-Rayet models. An additional finding concerns the transition in spectral morphology of the Of and WN characteristic He II line at 4686 Angstrom. When we express our mass-loss predictions as a function of the electron scattering Gamma_e (=L/M) only, we obtain a mass-loss Gamma dependence that is consistent with a previously reported power-law Mdot propto Gamma^5 (Vink 2006) that was based on our semi-empirical modelling approach. When we express Mdot in terms of both Gamma and stellar mass, we find Mdot propto M^0.8 Gamma^4.8 for our high Gamma models. Finally, we confirm that the Gamma-effect on the mass-loss predictions is much stronger than that of an increased helium abundance, calling for a fundamental revision in the way mass loss is incorporated in evolutionary models of the most massive stars.Comment: minor language changes (Astronomy & Astrophysics in press - 11 pages, 10 figures