Collective Flow Measurements from the PHENIX Experiment

Recent collective flow measurements including higher moment event anisotropy from the PHENIX experiment are presented, and the particle type, beam energy dependence and the relation with jet modification are discussed. The measured higher order event anisotropy with event plane defined at forward rapidities and the long range correlation with large $\eta$ gaps are both consistent with initial geometrical fluctuation of the participating nuclei. In 200 GeV Au+Au collisions, higher order event anisotropy, especially simultaneous description of v$_2$ and v$_3$, is found to give an additional constraining power on initial geometrical condition and viscosity in the hydrodynamic calculations. v$_2$, v$_3$ and v$_4$ are almost unchanged down to the lower colliding energy at 39 GeV in Au+Au. The measured two particle correlation with subtraction of the measured v$_n$ parameters shows a significant effect on the shape and yield in the associate particle $\Delta\phi$ distribution with respect to the azimuthal direction of trigger particles. However some medium responses from jet suppression or jet modification seems to be observed. Direct photon v$_2$ has been measured in 200 GeV Au+Au collisions. The measured v$_2$ is found to be small at high p$_{\rm T}$ as expected from non-suppressed direct photon R$_{\rm AA}$ $\simeq$ 1, which can be understood as being dominated by prompt photons from initial hard scattering. On the other hand, at lower p$_{\rm T}$ $<$ 4 GeV/c it is found to be significantly larger than zero, which is comparable to other hadron v$_2$, where thermal photons are observed.Comment: 8 pages, 10 figures, Quark Matter 2011 proceeding

Theory of x-ray absorption by laser-dressed atoms

An ab initio theory is devised for the x-ray photoabsorption cross section of atoms in the field of a moderately intense optical laser (800nm, 10^13 W/cm^2). The laser dresses the core-excited atomic states, which introduces a dependence of the cross section on the angle between the polarization vectors of the two linearly polarized radiation sources. We use the Hartree-Fock-Slater approximation to describe the atomic many-particle problem in conjunction with a nonrelativistic quantum-electrodynamic approach to treat the photon-electron interaction. The continuum wave functions of ejected electrons are treated with a complex absorbing potential that is derived from smooth exterior complex scaling. The solution to the two-color (x-ray plus laser) problem is discussed in terms of a direct diagonalization of the complex symmetric matrix representation of the Hamiltonian. Alternative treatments with time-independent and time-dependent non-Hermitian perturbation theories are presented that exploit the weak interaction strength between x rays and atoms. We apply the theory to study the photoabsorption cross section of krypton atoms near the K edge. A pronounced modification of the cross section is found in the presence of the optical laser.Comment: 13 pages, 3 figures, 1 table, RevTeX4, corrected typoe

Properties of metastable alkaline-earth-metal atoms calculated using an accurate effective core potential

The first three electronically excited states in the alkaline-earth-metal atoms magnesium, calcium, and strontium comprise the (nsnp) triplet P^o_J (J=0,1,2) fine-structure manifold. All three states are metastable and are of interest for optical atomic clocks as well as for cold-collision physics. An efficient technique--based on a physically motivated potential that models the presence of the ionic core--is employed to solve the Schroedinger equation for the two-electron valence shell. In this way, radiative lifetimes, laser-induced clock shifts, and long-range interaction parameters are calculated for metastable Mg, Ca, and Sr.Comment: 13 pages, 9 table

Quenching and Tomography from RHIC to LHC

We compare fully perturbative and fully nonperturbative pictures of high-pT energy loss calculations to the first results from LHC. While over-suppressed compared to published ALICE data, parameter-free pQCD predictions based on the WHDG energy loss model constrained to RHIC data simultaneously describe well the preliminary CMS hadron suppression, ATLAS charged hadron v2, and ALICE D meson suppression; we also provide for future reference WHDG predictions for B meson RAA. However, energy loss calculations based on AdS/CFT also qualitatively describe well the RHIC pion and non-photonic electron suppression and LHC charged hadron suppression. We propose the double ratio of charm to bottom quark RAA will qualitatively distinguish between these two energy loss pictures.Comment: 4 pages, 3 figures. Proceedings for Quark Matter 201

Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment

BACKGROUND: Adoptive immunotherapy with cytotoxic T lymphocytes (CTL) represents an alternative approach to treating solid tumors. Ideally, this would confer long-term protection against tumor. We previously demonstrated that in vitro-generated tumor-specific CTL from the ovalbumin (OVA)-specific OT-I T cell receptor transgenic mouse persisted long after adoptive transfer as memory T cells. When recipient mice were challenged with the OVA-expressing E.G7 thymoma, tumor growth was delayed and sometimes prevented. The reasons for therapeutic failures were not clear. METHODS: OT-I CTL were adoptively transferred to C57BL/6 mice 21 – 28 days prior to tumor challenge. At this time, the donor cells had the phenotypical and functional characteristics of memory CD8+ T cells. Recipients which developed tumor despite adoptive immunotherapy were analyzed to evaluate the reason(s) for therapeutic failure. RESULTS: Dose-response studies demonstrated that the degree of tumor protection was directly proportional to the number of OT-I CTL adoptively transferred. At a low dose of OT-I CTL, therapeutic failure was attributed to insufficient numbers of OT-I T cells that persisted in vivo, rather than mechanisms that actively suppressed or anergized the OT-I T cells. In recipients of high numbers of OT-I CTL, the E.G7 tumor that developed was shown to be resistant to fresh OT-I CTL when examined ex vivo. Furthermore, these same tumor cells no longer secreted a detectable level of OVA. In this case, resistance to immunotherapy was secondary to selection of clones of E.G7 that expressed a lower level of tumor antigen. CONCLUSIONS: Memory engraftment with tumor-specific CTL provides long-term protection against tumor. However, there are several limitations to this immunotherapeutic strategy, especially when targeting a single antigen. This study illustrates the importance of administering large numbers of effectors to engraft sufficiently efficacious immunologic memory. It also demonstrates the importance of targeting several antigens when developing vaccine strategies for cancer

UV-Spectrophotometric Determination of Telmisartan and Hydrochlorothiazide in Combined Tablet Dosage Form Using Simultaneous Equation Method

A UV spectrophotometric method was developed for the estimation of Telmisartan and Hydrochlorothiazide in Combined Tablet Dosage Form Using Simultaneous Equation Method. The drug obeyed the Beers law and shows good correlation near to r 2 = 0.999 for Telmisartan and for Hydrochlorothiazide r 2 =0.999.Absorption maxima of Telmisartan 296.8 nm and Hydrochlorothiazide 271.2 nm. Beers law was obeyed in concentration rang of 5-30 g/ml for Telmisartan and 2-12 g/ml for Hydrochlorothiazide. The method has been validated for linearity, accuracy and precision. The recovery was 99.28 % for Telmisartan and 99.26% for Hydrochlorothiazide. The developed method was found to be accurate, simple, precise, economical, and selective for simultaneous estimation of Telmisartan and Hydrochlorothiazide in tablet formulations

Analysis of Inelasticity Effect Due to Damage on Stress Distributions in Composite Laminates

A damage mechanics model characterizing damage behavior of composite materials proposed earlier by the authors is employed to analyze the damage effects on stress field near the free edge in symmetrically laminated graphite/epoxy composites of finite dimensions under umaxial tension. A quasi-three-dimensional finite element analy sis is developed for the present investigation. The results from the damaged and undam aged stress distributions of [0/90°]s, [90/0°]s, and [±45°] s laminates are compared and examined. The processes of initiation and development of damage zone in these composite laminates are also discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68869/2/10.1177_073168449301200805.pd