183 research outputs found
Brain rhythms define distinct interaction networks with differential dependence on anatomy
Cognitive functions are subserved by rhythmic neuronal synchronization across widely distributed brain areas. In 105 area pairs, we investigated functional connectivity (FC) through coherence, power correlation, and Granger causality (GC) in the theta, beta, high-beta, and gamma rhythms. Between rhythms, spatial FC patterns were largely independent. Thus, the rhythms defined distinct interaction networks. Importantly, networks of coherence and GC were not explained by the spatial distributions of the strengths of the rhythms. Those networks, particularly the GC networks, contained clear modules, with typically one dominant rhythm per module. To understand how this distinctiveness and modularity arises on a common anatomical backbone, we correlated, across 91 area pairs, the metrics of functional interaction with those of anatomical projection strength. Anatomy was primarily related to coherence and GC, with the largest effect sizes for GC. The correlation differed markedly between rhythms, being less pronounced for the beta and strongest for the gamma rhythm
Invasive left ventricle pressure-volume analysis: overview and practical clinical implications
Ventricular pressure-volume (PV) analysis is the reference method for the study of cardiac mechanics. Advances in calibration algorithms and measuring techniques brought new perspectives for its application in different research and clinical settings. Simultaneous PV measurement in the heart chambers offers unique insights into mechanical cardiac efficiency. Beat to beat invasive PV monitoring can be instrumental in the understanding and management of heart failure, valvular heart disease, and mechanical cardiac support. This review focuses on intra cardiac left ventricular PV analysis principles, interpretation of signals, and potential clinical applications
Phlebovirus diversity in ticks from livestock in arid ecologies in Kenya
DATA AVAILABILITY : Data will be made available on request.Phleboviruses are emerging pathogens of public health importance. However, their association with ticks is
poorly described, particularly in Africa. Here, adult ticks infesting cattle, goats and sheep were collected in two
dryland pastoralist ecosystems of Kenya (Baringo and Kajiado counties) and were screened for infection with
phleboviruses. Ticks mainly belonged to the species Rhipicephalus appendiculatus, Hyalomma impeltatum, and
Hyalomma rufipes. A fragment of the RNA-dependent RNA polymerase (RdRp) gene was identified in thirty of 671
tick pools, of which twenty-nine were from livestock sampled in Baringo county. Phylogenetic analyses revealed
that twenty-five sequences were falling in three clades within the group of tick-associated phleboviruses. The
sequences of the three clades showed nucleotide distances 8%, 19% and 22%, respectively, to previously known
viruses suggesting that these sequence fragments may belong to three distinct viruses. Viruses of the group of
tick-associated phleboviruses have been found in several countries and continents but so far have not been
associated with disease in humans or animals. In addition, five sequences were found to group with the sandflyassociated
phleboviruses Bogoria virus, Perkerra virus and Ntepes virus recently detected in the same region.
Further studies are needed to investigate the transmission and maintenance cycles of these viruses, as well as to
assess their potential to infect vertebrates.The Deutsche Forschungsgemeinschaft, the German Center for Infection Research (DZIF), Germany, a German Academic Exchange Service (DAAD) through the icipe ARPPIS-DAAD scholarship and a UP postgraduate bursary, a Wellcome Trust International Intermediate Fellowship, the Norad-funded project Combatting Arthropod Pests for better Health, Food and Climate Resilience, Swedish International Development Cooperation Agency (Sida), Swiss Agency for Development and Cooperation (SDC), Australian Centre for International Agricultural Research (ACIAR), Federal Democratic Republic of Ethiopia and the Government of the Republic of Kenya.https://www.elsevier.com/locate/ttbdisam2024Zoology and EntomologySDG-03:Good heatlh and well-bein
Pressure-volume analysis in athyroid patients off and on thyroxine supplementation: a pilot study
Thyroid hormone importantly affects the cardiovascular system. However, evaluation of stroke volume (SV)
Viral diversity and blood-feeding patterns of Afrotropical Culicoides biting midges (Diptera: Ceratopogonidae)
DATA AVAILABILITY STATEMENT : The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found in the article/supplementary material.INTRODUCTION : Culicoides biting midges (Diptera: Ceratopogonidae) are
vectors of arboviral pathogens that primarily affect livestock represented by
Schmallenberg virus (SBV), epizootic hemorrhagic disease virus (EHDV) and
bluetongue virus (BTV). In Kenya, studies examining the bionomic features of
Culicoides including species diversity, blood-feeding habits, and association
with viruses are limited.
METHODS : Adult Culicoides were surveyed using CDC light traps in two semiarid
ecologies, Baringo and Kajiado counties, in Kenya. Blood-fed specimens
were analysed through polymerase chain reaction (PCR) and sequencing
of cytochrome oxidase subunit 1 (cox1) barcoding region. Culicoides pools
were screened for virus infection by generic RT-PCR and next-generation
sequencing (NGS).
RESULTS : Analysis of blood-fed specimens confirmed that midges had fed
on cattle, goats, sheep, zebra, and birds. Cox1 barcoding of the sampled
specimens revealed the presence of known vectors of BTV and epizootic
hemorrhagic disease virus (EHDV) including species in the Imicola group
(Culicoides imicola) and Schultzei group (C. enderleni, C. kingi, and
C. chultzei). Culicoides leucostictus and a cryptic species distantly related
to the Imicola group were also identified. Screening of generated pools
(11,006 individuals assigned to 333 pools) by generic RT-PCR revealed
presence of seven phylogenetically distinct viruses grouping in the genera
Goukovirus, Pacuvirus and Orthobunyavirus. The viruses showed an overall
minimum infection rate (MIR) of 7.0% (66/333, 95% confidence interval (CI)
5.5-8.9). In addition, full coding sequences of two new iflaviruses, tentatively
named Oloisinyai_1 and Oloisinyai_2, were generated by next-generation sequencing (NGS) from individual homogenate of Culicoides pool.
CONCLUSION : The results indicate a high genetic diversity of viruses in Kenyan
biting midges. Further insights into host-vector-virus interactions as well as
investigations on the potential clinical significance of the detected viruses
are warranted.The Deutsche Forschungsgemeinschaft, a German Academic Exchange Service (DAAD) through the icipe ARPPIS-DAAD scholarship, a UP postgraduate bursary, the Norad-funded project Combatting Arthropod Pests for better Health, Food and Climate Resilience and ICIPE core donors: Swiss Agency for Development and Cooperation (SDC), Switzerland; Swedish International Development Cooperation Agency (Sida), Sweden; Australian Centre for International Agricultural Research (ACIAR), Federal Democratic Republic of Ethiopia and the Government of the Republic of Kenya.http://www.frontiersin.org/Microbiologyam2024Zoology and EntomologySDG-03:Good heatlh and well-beingSDG-15:Life on lan
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