Regulation of arteriogenesis: Mechanistic studies and options for therapeutic intervention

The studies included in this thesis demonstrated a preclinical murine model to study neovascularization in vivo and subsequently a number of potential targets to stimulate therapeutic neovascularization. This thesis contributes to a better insight into mechanisms underlying post-ischemic neovascularization and offers new therapeutic perspective to current treatment strategies for patients with critical limb ischemia. Whether stagnated blood flow recovery after an occlusive event is due to restricted pre-existing collateral bed or due to decreased collateral remodeling, we are now closer to a tailor made treatment available for each patient with peripheral arterial disease.LUMC / Geneeskunde Repositoriu

Toll-like Receptor 4 Inhibitor TAK-242 Treatment Does Not Influence Perfusion Recovery in Tissue Ischemia

Vascular Surger

Induction of hind limb ischemia in mice: comparison of different models for therapeutic arteriogenesis

Vascular Biology and Interventio

A comparison of the Doppler-derived maximal systolic acceleration versus the ankle-brachial pressure index or detecting and quantifying peripheral arterial occlusive disease in diabetic patients

Aim The aim of this study was to assess the diagnostic accuracy of the Doppler derived maximal systolic acceleration (ACC(max)) as a novel technique for evaluating peripheral arterial occlusive disease (PAOD) in patients with diabetes mellitus, who are known for a falsely elevated ankle-brachial index (ABI). Methods. In this retrospective analysis ACC(max) was measured at ankle level in a series of 163 consecutive patients referred to the vascular laboratory for initial assessment of PAOD. Patients were classified according to the presence or absence of diabetes. In the non-diabetic patients PAOD was defined as ABI 10 m/s(2) was found to be highly predictive for the exclusion of PAOD (negative predictive value 95%). In addition, the ACC(max) cut-off value of <6.5 m/s(2) was highly predictive for the detection of PAOD (positive predictive value 99%). A strong quadratic association was found between ACC(max) and ABI in the non-diabetic group (R-2=0.85). In the diabetic patients R-2 values were 0.81 and 0.79 after ABI and TBI measurement respectively. Conclusion. DUS-derived ACC(max) an accurate marker that could offer significant benefits for the diagnosis of PAOD, especially in diabetic patients.Vascular Surger

Inhibition of 14q32 microRNAs drastically improves blood flow recovery after ischemia

Vascular Surger

Variations in Surgical Procedures for Hind Limb Ischaemia Mouse Models Result in differences in Collateral Formation

Endocrinolog

A limited role for regulatory T cells in post-ischemic neovascularization

Vascular Surger

CCR7-CCL19/CCL21 Axis is Essential for Effective Arteriogenesis in a Murine Model of Hindlimb Ischemia

Vascular Surger