Managing innovation uncertainties : a user-oriented knowledge typology

New product development processes are subject to uncertainties. These uncertainties can and should be managed to prevent innovations from failing. Uncertainties or knowledge deficits are addressed by deploying the right approaches, or learning activities to stimulate relevant inflows of knowledge. A typology of user-oriented knowledge types is key to overcome the reluctance of organizations towards multi-actor involvement and user-oriented learning activities. Here, we present a user-oriented knowledge typology departing from the end-user, embedded in a two-states framework (current state opposing future state). We discuss three iterations of the framework, including an expert review and real-world application as part of a workshop with intermediary organizations. When implemented, the framework enabled participants to identify and select learning activities enriching their innovation project. We want to underline our vision to transcend the gut-feeling and experience-driven allocation of learning activities, but instead strive towards optimal activity-selection based on the knowledge deficit at hand

The role of urban living labs in a smart city

In a rapidly changing socio-technical environment cities are increasingly seen as main drivers for change. Against this backdrop, this paper studies the emerging Urban Living Lab and Smart City concepts from a project based perspective, by assessing a series of five Smart City initiatives within one local city ecosystem. A conceptual and analytical framework is used to analyse the architecture, nature and outcomes of the Smart City Ghent and the role of Urban Living Labs. The results of our analysis highlight the potential for social value creation and urban transition. However, current Smart City initiatives face the challenge of evolving from demonstrators towards real sustainable value. Furthermore, Smart Cities often have a technological deterministic, project-based approach, which forecloses a sustainable, permanent and growing future for the project outcomes. ‘City-governed’ Urban Living Labs have an interesting potential to overcome some of the identified challenges

Urban socio-technical innovations with and by citizens

This article investigates bottom-up socio-technical innovations with and by citizen developers in an Urban living Lab, which is considered a platform for grassroots service creation in a city. In specific, the Living Lab framework is discussed as an instrumental platform within a Smart City, facilitating the governance of bottom-up innovation ‘by’ and ‘with’ citizens. The analysis is based on an in-depth case-study analysis on the use of Open Data and the ‘hackathon’ format within the Ghent Living Lab (Ghent, Belgium). The analytical framework focusses on the innovation ecosystem, urban transitions, user innovation, civic engagement, public and economic value creation and sustainability issues. Our findings explore the nature of the interactions and the outcomes of the projects. While hackathon events within an Urban Living Lab have already proven some of their potential, several opportunities remain. Especially the lack of involvement of private partners and a rather low focus on potential business models for the projects forecloses long-term sustainability and economic value creation. Central governance, focus on follow-up processes and a rigid innovation development framework are needed to overcome these challenges

Hannover study on long-stay hospitalization – part I: prediction of long-stay hospitalisation in cases of chronic mental illness

BACKGROUND: The problem of long-stay hospitalization is still a pressing issue. In this study we examined the possibility of detecting and characterising the group at risk of long-stay hospitalization in advance. METHODS: This study examines the data of patients in the urban catchment area of the Medical University of Hannover, capital of Lower Saxony, Germany, during a period of 10 years. RESULTS AND CONCLUSION: The introduced "psychosocial risk-score", calculated at the first institutional contact, was able to predict the risk of long-term hospitalization. Characteristics of social disintegration, especially with regard to employment status, are of particular importance

Assessment of the attraction flow in a fish passage

An attraction flow can be used to increase the effectivity of a fish passage. In 2004 a fish passage with a perpendicular attraction flow was built at Oudenaarde (Belgium) on the Upper Scheldt river. The design of the passage was based on scale model tests. In order to evaluate the hydraulic effectivity of the attraction flow, field measurements and new scale model tests are done. Velocities in the attraction flow and the fish passage entrance are assessed quantitatively and data of the scale model tests (1/15) are compared with the field measurements. The measured reach of the attraction flow seems to differ from results of the original scale model tests due to design modifications of the fish passage entrance. Results of the new scale model tests compare well with the data from the field measurements. Based on the results, a re-examination of the basic design rules for the attraction flow and fish pass entrances seems imperativ

Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1

Polycomb group proteins, as part of the Polycomb repressive complexes, are essential in gene repression through chromatin compaction by canonical PRC1, mono-ubiquitylation of histone H2A by non-canonical PRC1 and tri-methylation of histone H3K27 by PRC2. Despite prevalent models emphasizing tight functional coupling between PRC1 and PRC2, it remains unclear whether this paradigm indeed reflects the evolution and functioning of these complexes. Here, we conduct a comprehensive analysis of the presence or absence of cPRC1, nPRC1 and PRC2 across the entire eukaryotic tree of life, and find that both complexes were present in the Last Eukaryotic Common Ancestor (LECA). Strikingly, ~42% of organisms contain only PRC1 or PRC2, showing that their evolution since LECA is largely uncoupled. The identification of ncPRC1-defining subunits in unicellular relatives of animals and fungi suggests ncPRC1 originated before cPRC1, and we propose a scenario for the evolution of cPRC1 from ncPRC1. Together, our results suggest that crosstalk between these complexes is a secondary development in evolution.</p

Uncoupled evolution of the Polycomb system and deep origin of non-canonical PRC1

Polycomb group proteins, as part of the Polycomb repressive complexes, are essential in gene repression through chromatin compaction by canonical PRC1, mono-ubiquitylation of histone H2A by non-canonical PRC1 and tri-methylation of histone H3K27 by PRC2. Despite prevalent models emphasizing tight functional coupling between PRC1 and PRC2, it remains unclear whether this paradigm indeed reflects the evolution and functioning of these complexes. Here, we conduct a comprehensive analysis of the presence or absence of cPRC1, nPRC1 and PRC2 across the entire eukaryotic tree of life, and find that both complexes were present in the Last Eukaryotic Common Ancestor (LECA). Strikingly, ~42% of organisms contain only PRC1 or PRC2, showing that their evolution since LECA is largely uncoupled. The identification of ncPRC1-defining subunits in unicellular relatives of animals and fungi suggests ncPRC1 originated before cPRC1, and we propose a scenario for the evolution of cPRC1 from ncPRC1. Together, our results suggest that crosstalk between these complexes is a secondary development in evolution

A precious metal alloy for construction of MR imaging-compatible balloon-expandable vascular stents

The authors developed ABI alloy, which mechanically resembles stainless steel 316. The main elements of ABI alloy are palladium and silver. Magnetic resonance (MR) images and radiographs of ABI alloy and stainless steel 316 stent models and of nitinol, tantalum, and Elgiloy stents were compared. ABI alloy showed the least MR imaging artifacts and was more radiopaque than stainless steel 316. ABI alloy has the potential to replace stainless steel 316 for construction of balloon-expandable MR imaging-compatible stents