Increased carotid IMT in overweight and obese women affected by Hashimoto's thyroiditis: an adiposity and autoimmune linkage?

<p>Abstract</p> <p>Background</p> <p>Hashimoto's thyroiditis is the most important cause of hypothyroidism. It is a systemic disease that can even affect the cardiovascular system, by accelerating the atherosclerotic process. Aim of this study was to examine whether autoimmune thyroiditis has an effect on the intima-media thickness of the common carotid artery (IMT-CCT), independently of the thyroid function and well-known cardiovascular risk factors. Hashimoto's thyroiditis is a systemic disease. The aim is to examine whether autoimmune thyroiditis and adiposity can effect carotid IMT independently of thyroid hormones and cardiovascular risk factors.</p> <p>Methods</p> <p>A total of 104 obese women (BMI ≥ 25.0 kg/m^-2), with FT3 and FT4 serum levels in the normal range and TSH levels < 4.5 μU/ml, were investigated. None of these patients was taking any kind of drug influencing thyroid function. Measurements were made of the IMT-CCT, BMI, waist circumference, blood pressure levels, as well as fasting TSH, FT3, FT4, anti-thyroid antibodies, insulin, fasting glycemia, triglycerides, total and HDL-cholesterol serum concentrations.</p> <p>Results</p> <p>Of the 104 women, 30 (28.8%) were affected by autoimmune thyroiditis. Significantly higher values of IMT-CCT (p < 0.05), TSH (p < 0.05), and triglycerides (p < 0.05) were obtained, and significantly lower values of FT4 (p < 0.05), in patients with Hashimoto's thyroiditis as compared to those with a normal thyroid function. When examining the whole group together, at multiple regression analysis Hashimoto's thyroiditis maintained a positive association with the IMT (p < 0.001), independently of age, hypertension, BMI, and the fasting serum levels of TSH, FT3, FT4, insulin, fasting glycemia, triglycerides, total and HDL-cholesterol levels.</p> <p>Conclusions</p> <p>The present study shows that Hashimoto's thyroiditis is associated to an increased IMT only in overweight and obese, independently of the thyroid function, BMI and cardiovascular risk factors. These results suggest that Hashimoto's thyroiditis is a marker of evolution of the atherosclerosis if combined to adiposity.</p

Etude anatomo-clinique et expérimentale des inflammations chroniques et des scléroses du corps thyroïde

Doctorat en sciences médicalesinfo:eu-repo/semantics/nonPublishe

APPORTS RECENTS DE L'IMMUNOLOGIE A LA PATHOLOGIE THYROIDIENNE

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

SOME EFFECTS OF B.Z. 55 ON THE CARBOHYDRATE METABOLISM OF DIABETIC PATIENTS

SCOPUS: le.jinfo:eu-repo/semantics/publishe

PARALYTIC ILEUS IN SEVERE HYPOTHYROIDISM

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

DIABETE ET MALADIES AUTOIMMUNITAIRES

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

AUTO IMMUNITE ET DIABETE

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Pathology of spontaneous myxedema in the aged

Autopsy findings are reported in 29 cases of myxedema observed in aged patients. In 7 cases the hypothyroidism was due to a primary destructive lesion of the pituitary gland. In 22 cases the hypothyroidism was related to an atrophic cirrhosis of the thyroid, the preclinical stages of which have been investigated.SCOPUS: cp.jinfo:eu-repo/semantics/publishe

Hypothyroidism and coronary heart disease

In contrast to general opinion, hypothyroidism is not an infrequent disease: it affects 1.5% of the Western populations and 1/3 of the cases remain undiagnosed. Latent hypothyroidism, easily detected by the assay of circulating thyroid antibodies and graded by the estimation of serum TSH, is present in a further 3 to 5 per cent of the general population. Whereas overt hypothyroidism is a definite cause of vascular damage, the role of subclinical hypothyroidism as a risk factor of CHD remains debatable Several independent studies suggest that the importance of this role may depend on the presence or absence of other risk factors. Practically latent hypothyroidism should be looked for in all cases of unexplained hyperlipidaemia and in all women over the age of 50. In all cases with biological signs of grade III AAT, careful exploration of the cardiovascular state should be considered before substitutive therapy is started.SCOPUS: ar.jinfo:eu-repo/semantics/publishe