A compact system for intraoperative specimen imaging based on edge illumination x-ray phase contrast

“This is an author-created, un-copyedited version of an article accepted for publication/published in Physics in Medicine & Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1361-6560/ab4912

Laboratory-based X-ray phase-contrast imaging with misaligned optical elements

We report on a laboratory X-ray phase-contrast imaging technique based on the edge illumination principle that substantially relaxes the existing limitations on system set up and data acquisition, allowing an increase in tolerance of misalignments by at least two orders of magnitude. The robustness of this approach was systematically studied by means of experiments with our prototype. Numerical simulations were also performed in order to assess the dependence of the image quality on the data acquisition scheme. The results show that errors in the positioning of the masks within a 1 degree range for all the angles, and within 1 mm range of translation, do not noticeably affect image quality. We also show that, if the misalignment does not exceed few tens of micrometers, three intensity projections are sufficient to effectively retrieve the three representations of the sample, allowing for optimization of dose or time efficiency even with a non-ideal system

Agente terapeutico per il trattamento dei vasi sanguigni

La presente invenzione ha per oggetto un agente terapeutico per il trattamento dei vasi sanguigni, preferibilmente utilizzato sugli stent coronarici, caratterizzato dal fatto di comprendente composti a nucleo 2,3-difenil-4H-pirido[1,2-a]pirimidin-4-onico

Therapeutic agent for treatment of blood vessels

A therapeutic agent for the treatment of blood vessels, preferably applied to coronary stents, characterised in that it comprises compounds with a 2,3-diphenyl-4H-pyrido[1,2-a]pyrimidine-4-one nucleu

Beam tracking approach for single–shot retrieval of absorption, refraction, and dark–field signals with laboratory x–ray sources

We present the translation of the beam tracking approach for x–ray phase–contrast and dark–field imaging, recently demonstrated using synchrotron radiation, to a laboratory setup. A single absorbing mask is used before the sample, and a local Gaussian interpolation of the beam at the detector is used to extract absorption, refraction, and dark–field signals from a single exposure of the sample. Multiple exposures can be acquired when high resolution is needed, as shown here. A theoretical analysis of the effect of polychromaticity on the retrieved signals, and of the artifacts this might cause when existing retrieval methods are used, is also discussed

Achromatic approach to phase-based multi-modal imaging with conventional X-ray sources

Compatibility with polychromatic radiation is an important requirement for an imaging system using conventional rotating anode X-ray sources. With a commercially available energy-resolving single-photon-counting detector we investigated how broadband radiation affects the performance of a multi-modal edge-illumination phase-contrast imaging system. The effect of X-ray energy on phase retrieval is presented, and the achromaticity of the method is experimentally demonstrated. Comparison with simulated measurements integrating over the energy spectrum shows that there is no significant loss of image quality due to the use of polychromatic radiation. This means that, to a good approximation, the imaging system exploits radiation in the same way at all energies typically used in hard-X-ray imaging

Achromatic approach to phase-based multi-modal imaging with conventional X-ray sources

Compatibility with polychromatic radiation is an important requirement for an imaging system using conventional rotating anode X-ray sources. With a commercially available energy-resolving single-photon-counting detector we investigated how broadband radiation affects the performance of a multi-modal edge-illumination phase-contrast imaging system. The effect of X-ray energy on phase retrieval is presented, and the achromaticity of the method is experimentally demonstrated. Comparison with simulated measurements integrating over the energy spectrum shows that there is no significant loss of image quality due to the use of polychromatic radiation. This means that, to a good approximation, the imaging system exploits radiation in the same way at all energies typically used in hard-X-ray imaging