Profile of adverse events in plateletpheresis and plasmapheresis donors in a tertiary care hospital of North India

Background: Apheresis procedures are usually well tolerated. Adverse events (AEs) associated with the use of cell separators can be due to delivery of the anticoagulant, vasovagal, allergy, venous access or machines malfunction. Aim was to study the profile of adverse events of plateletpheresis and plasmapheresis donors. Methods: Plateletpheresis and plasmapheresis procedures enrolled for donors during 2017-2018 were done after taking informed and written consent by using Trima Accel and MCS+cell separator. Donor related AEs were categorised according to severity, site and etiology. Non-donor related (NDR) AEs were kit, technique, or equipment related. Results: 2859 procedures were done, 2836 (99.19%) plateletpheresis and 23 (0.8%) plasmapheresis. All 145 (5.07%) AEs were seen in plateletpheresis. Majority of AEs, 130 (4.54%) were DR. 15 (0.52%) were NDR. Commonest DR AEs was citrate related (CR) 76 (2.6%), followed by vasovagal reaction (VVR) in 31 (1.08%) and vascular injury in 23 (0.8%). Majority of the AEs were mild in 124 (4.33%), only 6 (0.20%) were moderate. 107 (3.74%) AEs were (VI) systemic, while 23 (0.80%) were local. In local AEs, hematomas were more common. First time donors had more AEs, 62/1234 (5.02%) as compared to the repeat donors 68/1625 (4.18%). CR AEs were more in repeat donors, 46 (2.8%) as compared to first time donors, 30 (2.43%). VVRs and VIs were more in first time as compared to the repeat donors. NDR AEs were 15 (0.52%). Conclusions: Donor vigilance, trained technical personnel and specialists’ supervision are vital for donor safety hence affecting apheresis donor pool

Seroprevalence of human immunodeficiency virus, hepatitis B and hepatitis C among blood donors at a tertiary care hospital in North India

Background: The prevalence of transfusion transmitted infections (TTIs), in blood transfusion services are a major problem across blood banks and hospitals in the world. In, India, the effort to provide safe transfusion to patients is a heightened problem for various reasons. In this study, seroprevalence of Transfusion transmitted infections such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) was investigated in a pool of blood donors.Methods: The data collection was carried out for a period of two years from, January 2017 to December 2018, and total sample size of donors was 38,142. We studied the frequency, gender wise distribution, donor (first time vs repeat) wise distribution and yearly trend of seroprevalence of TTIs in blood units donated at our hospital.Results: A total of 37,457 (98.2%) males and 685 (1.79%) females donated blood during the study period. The results suggest that among the blood donors, the prevalence of HCV was highest (0.77%) followed by HBV (0.46%) and HIV (0.13%). Seropositivity was found to be more in first-time donors (0.83%) as compared to repeat-donors (0.52%). Seropositivity was found to be more among males (1.35%) than females (0.01%). The discussion suggests underlying reasons for the results along-with future direction of research.Conclusions: The need of the hour is to encourage repeat voluntary blood donors in order to maintain safe supply of blood and its components to donors. Efforts should be made to include females in the blood donor pool by increasing awareness and through dedicated efforts to improve female health and nutrition

Plateletpheresis adverse events in relation to donor and plateletpheresis session profile

Introduction: Increasing demand of platelet transfusions for patients has led to a trend in the increased use of automated blood collections. These share many of the same reactions and injuries seen with pooled platelets obtained from whole blood donation but also have unique complications. Aims And Objectives: To study the adverse events (AEs) of plateletpheresis procedure and their relationship with donor and plateletpheresis procedure session profiles. Materials And Methods: This is a retrospective observational study conducted from January 2016 to December 2016. A two-hundred and thirteen (213) plateletpheresis procedures were performed after taking informed and written consent from the donor. All the donors were male and selected according to the guidelines laid down by Director General of Health Services. The AEs were classified into donor related, kit/equipment related and technique related. Results: A total of 13 AEs were noted; of which, 8 (61.53 %) events were associated with donors, 3 (23.07 %) were owed to fault in kit/equipment and 2 (15.384 %) were due to technical aberrations. Donor related AEs included vascular injuries [n = 3 (1.40%)], vasovagal reactions [n = 2 (0.938%)] and perioral tingling sensation [n = 3 (1.40%)]. Technique related AEs [n = 2 (0.938%)] and kit/equipment related AEs [n = 3 (1.40%)] were due to faulty technique and defective kits respectively. Conclusion: Apheresis donations performed on cell separators are safe. Meticulous donor vigilance, superior technical personnel training and experienced transfusion medicine specialist's supervision will make donor's experience more pleasant