Fisher z-transformed FC matrix of rat brain.

<p>a) Mean FC matrix (40 subjects) showing pairwise partial correlation coefficients obtained for 36 brain regions. b) Standard deviation matrix of the partial correlation coefficients. For abbreviations of brain regions see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#pone-0106156-g001" target="_blank">Figure 1</a>.</p

Modular organization in 4 different groups.

<p>Group plots with high modular similarity (low variability) in subjects randomly split into four groups (a–d) visualized on schematic mid sagittal sections of the rat brain. Network hubs are depicted by larger circles. The colors used for the sub-networks of the six functional modules, as identified by the modularity partitioning algorithm (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#s2" target="_blank">methods</a>), are analogue to those used in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#pone-0106156-g004" target="_blank">Figure 4c</a>. For abbreviations of brain regions see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#pone-0106156-g001" target="_blank">Figure 1</a>.</p

Modular organization of rat FCN and centrality of brain regions.

<p>a) Mean FC matrix rearranged with functional modules labeled along the major diagonal of the matrix. Six functional modules (sub-networks) of brain regions, as identified by the modularity partitioning algorithm (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#s2" target="_blank">methods</a>), are labeled in different colors. b) In the first row brain regions are shown in descending order of their generalized connection strength. Strong (strength>mean) brain areas are shown in red bars; the horizontal line indicates the mean strength. In the second row brain regions are shown in descending order of their generalized diversity value. Here, red bars show brain regions with strong connections as determined in the first row. Network hubs (i.e., nodes that are both strong and diverse) are indicated by green triangles. c) FCN modules are visualized on a schematic mid sagittal section of the rat brain. Network hubs are depicted by larger circles. For abbreviations of brain regions see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106156#pone-0106156-g001" target="_blank">Figure 1</a>. The colors used for the different modules are the same as those used in Figure 4a.</p

Reproducibility of FC across subjects.

<p>The histograms (in blue) represent the distribution of the partial correlation coefficients (z-transformed) for each of the four randomly partitioned subject groups. Scatter plots indicating high correlation (r>0.85) of the pair-wise FC values between the groups suggest high reproducibility of FC at a group level.</p