Morphology and morphometry of mental foramen in dry human mandibles

Background: Mental foramen (MF) is an important landmark to facilitate surgical, local anaesthetic and other invasive procedures. The present study was aimed to provide anatomical information on the position, morphological variations and incidence of mental foramen and accessory mental foramen.Methods: This study was conducted on 41 dry adult human mandibles in the department of anatomy, Government Medical College Srinagar, Jammu and Kashmir. Parameters like incidence, position, shape and presence of accessory mental foramen were studied.Results: Mental foramen was present bilaterally in all 41 mandibles. Accessory mental foramen(AMF) was present in 2 cases (4.87%). The most frequent position of foramen in relation to the teeth was in line with the longitudinal axis of 2nd premolar on both right (63.42%) and left (60.98%) side. Most common shape was round shape.Conclusions: Mental foramen variation often remains unnoticed and undiagnosed. Variations do exist in the position, shape, and size of mental foramen in different population groups. Present study provide the necessary data of  mental foramen location and morphometry which may be useful for the surgeons, anaesthetists, neurosurgeons and dentists to carry out nerve block and surgical procedures

Efficacy of memantine in treating patients with migraine and tension-type headache

Objective: To assess the efficacy of Memantine as a preventive and therapeutic intervention for migraine and tension-type headache. Methods: This clinical trial was conducted over a period of 3 months. A total of 44 subjects, with diagnosed migraine and/or tension-type headache, presenting to a private neurology clinic in Karachi, Pakistan were selected through purposive sampling technique. Patients were treated with incremental doses of Memantine. Adult patients belonging to both genders were included in the study. Data was analyzed using SPSS version 16.0 and associations were made using Chi square test with p-value of less than 0.05 taken as significant. Results: Out of 44 patients, 35 (79.5%) were females and 9 (20.5%) were males which shows a very high occurrence of migraine and tension-type headache in females. Average age was found to be 32.6 ≈ 33 years. Efficacy of the drug was observed to be 81.8% which is significantly high. The baseline MIDAS score when compared with the score at 3-month follow-up by applying Wilcoxon signed rank test showed mean ± S.D (39.52±21.27 vs. 6.72±6.41) where p=0.000 (\u3c0.05) which shows a highly significant result. All 44 patients were known cases of migraine while 25% (11) of them also suffered from tension-type headache. Patients were treated with incremental doses of Memantine and were observed for the efficacy of the drug. Patients maintained their diaries of intensity of pain, distressing influence of the pain and how it hindered their daily routine. Results showed that intensity of pain decreased significantly by the end of the 3rd month of treatment and majority of the patients felt less distressed on their final follow-up visit. By the end of the 3rd month, the level of hindrance in the daily routines of the patients caused by the headache also fell significantly. Conclusion: Memantine has significant beneficial effects in reducing intensity of pain and disability in patients with migraine and tension type headache

Comparative study to evaluate the effect of colloid coloading versus crystalloid coloading for prevention of spinal anaesthesia induced hypotension and effect on fetal Apgar score in patients undergoing elective lower segment caesarean section: a prospective observational study

Background: Spinal anesthesia for LSCS has a high incidence of maternal hypotension which can be severe and disastrous for the fetus and the mother. Coloading in these patients is a physiologically more appropriate method for preventing spinal anesthesia induced hypotension.Methods: 100 ASA I patients for elective LSCS were randomly divided into two equal groups to either receive 1000ml colloid (6% Hetastarch) or 1000ml crystalloids (Ringer lactate) as coload. NIBP, heart rate SPO2 and incidence of nausea and vomiting and use of ephedrine to treat any hypotension was recorded. Fetal outcome was measured using APGAR score at 0, 1 and 5 minutes.Results: The incidence of hypotension was lesser with colloid coload group (41.7%) as compared to the crystalloid coload group (58.3%) but the difference between the two groups was statistically insignificant. Similarly, no statistically significant difference was noted in the incidence of nausea and vomiting and Fetal APGAR score between the two groups.Conclusions: Both Colloid and Crystalloid coloading is effective in decreasing the incidence of spinal anesthesia induced hypotension during LSCS with lesser incidence of hypotension and nausea vomiting with colloid coloading

The Soybean Genome Database (SoyGD): a browser for display of duplicated, polyploid, regions and sequence tagged sites on the integrated physical and genetic maps of Glycine max

Genomes that have been highly conserved following increases in ploidy (by duplication or hybridization) like Glycine max (soybean) present challenges during genome analysis. At the Soybean Genome Database (SoyGD) genome browser has, since 2002, integrated and served the publicly available soybean physical map, bacterial artificial chromosome (BAC) fingerprint database and genetic map associated genomic data. The browser shows both build 3 and build 4 contiguous sets of clones (contigs) of the soybean physical map. Build 4 consisted of 2854 contigs that encompassed 1.05 Gb and 404 high-quality DNA markers that anchored 742 contigs. Many DNA markers anchored sets of 2–8 different contigs. Each contig in the set represented a homologous region of related sequences. GBrowse was adapted to show sets of homologous contigs at all potential anchor points, spread laterally and prevented from overlapping. About 8064 minimum tiling path (MTP2) clones provided 13 473 BAC end sequences (BES) to decorate the physical map. Analyses of BES placed 2111 gene models, 40 marker anchors and 1053 new microsatellite markers on the map. Estimated sequence tag probes from 201 low-copy gene families located 613 paralogs. The genome browser portal showed each data type as a separate track. Tetraploid, octoploid, diploid and homologous regions are shown clearly in relation to an integrated genetic and physical map

To compare the clinical efficacy and side effects of implant (Jadelle) and IUCD (Copper T)

This study aims to compare the performance and side effects of the subdermal implant JADELLE and intrauterine contraceptive device Copper-T as long-acting reversible contraceptive methods. The study design involved a comparative analysis of Jadelle and Copper-T contraceptives, assessing clinical performance and side effects. Sample data from 336 participants was collected using stratified random sampling, with standardized instruments for demographic information, clinical assessment, and contraceptive side effects. Inclusion criteria were reproductive-age multipara women, while exclusion criteria included primary para, preexisting medical disorders, nullipara, and other contraceptive use. Ethical guidelines were followed, ensuring informed consent, privacy, and the right to withdraw. Statistical analysis employed descriptive statistics, chi-square test, independent samples t-test, and Kaplan-Meier survival analysis. SPSS (version 23.0) was used for analysis. The comparison between Group A (Jadelle) and Group B (Copper-T) reveals interesting findings. Group A has a higher mean age, but no significant differences in parity, blood pressure, or weight. Group B has more total and ongoing pregnancies. Group A experiences higher prevalence of side effects, including expulsion, infection, severe menstrual changes, pain or discomfort, and mood swings. Blood parameters show no significant differences. Variations exist in follow-up rates, informed consent, and privacy maintenance.&nbsp

Cu(OH)x: Clay Catalyst Promoted Synthesis of 4,5-dihydro-1,2,4-oxadiazole at Room Temperature

An easy and efficient scheme is described designed for the preparation of 4,5-dihydro-1,2,4-oxadiazole using recyclable Cu(OH)x-Clay heterogeneous catalyst at room temperature. The cyclo-addition reaction is carried out between imine and oxime using an easy protocol where nitrile oxides are produced in-situ from aldoximes and reacted with imines to construct 1,2,4-oxadiazolines in good yield and tremendous purity.   Cu(OH)x-Clay catalyst shows excellent catalytic activity for the formation of 1,2,4-oxadiazole. The technique is practically uncomplicated, inexpensive, and excellent with wide range of functional group tolerance to generate structurally different 1,2,4-oxadiazoles. The prepared catalyst was investigated by XRD and SEM techniques. The final products of synthesized compound were characterized by FTIR, NMR spectroscopy and mass spectrometry. DOI: http://dx.doi.org/10.17807/orbital.v9i5.1062 </p

To compare the clinical efficacy and side effects of implant (JADELLE) and IUCD (COPPER T)

This study aims to compare the performance and side effects of the subdermal implant JADELLE and intrauterine contraceptive device Copper-T as long-acting reversible contraceptive methods. The study design involved a comparative analysis of Jadelle and Copper-T contraceptives, assessing clinical performance and side effects. Sample data from 336 participants was collected using stratified random sampling, with standardized instruments for demographic information, clinical assessment, and contraceptive side effects. Inclusion criteria were reproductive-age multipara women, while exclusion criteria included primary para, preexisting medical disorders, nullipara, and other contraceptive use. Ethical guidelines were followed, ensuring informed consent, privacy, and the right to withdraw. Statistical analysis employed descriptive statistics, chi-square test, independent samples t-test, and Kaplan-Meier survival analysis. SPSS (version 23.0) was used for analysis. The comparison between Group A (Jadelle) and Group B (Copper-T) reveals interesting findings. Group A has a higher mean age, but no significant differences in parity, blood pressure, or weight. Group B has more total and ongoing pregnancies. Group A experiences higher prevalence of side effects, including expulsion, infection, severe menstrual changes, pain or discomfort, and mood swings. Blood parameters show no significant differences. Variations exist in follow-up rates, informed consent, and privacy maintenance.&nbsp

Child-Pugh Score, MELD Score and Glasgow Blatchford Score to Predict the In-Hospital Outcome of Portal Hypertensive Patients Presenting with Upper Gastrointestinal Bleeding: An Experience from Tertiary Healthcare System

The two most familiar scores used for prognostication of liver cirrhosis are the Model for End-stage Liver Disease (MELD) and Child-Turcotte-Pugh (CTP), while the Glasgow-Blatchford (GB) score is used for sorting non-variceal upper gastrointestinal hemorrhage into high- or low-risk categories. This study evaluates the validity of the CTP, MELD, and GB scoring systems in prognosticating the in-hospital outcome of bleeding portal hypertensive patients. In this study, the ROC curve and Younden index determine the efficacy of three scoring systems. The results indicate that CTP was the most efficient score as the predictor of outcome (AUC = 0.9, cut-off value &gt; 7); followed by MELD (AUC = 0.8, cut-off value &gt; 18) and then the GB score (AUC = 0.64, cut-off value &gt; 14) (p &lt; 0.05). In pair-wise comparison, the difference between CTP and MELD was insignificant (p &gt; 0.05). Patients with a CTP score of &gt;7 had notably higher in-hospital mortality (19.8% vs. 0.9%, p &lt; 0.0001). Similarly, mortality with a MELD score &gt; 18 was significant (14.8% vs. 5.9% (p &lt; 0.0001). The GB score was not a good indicator of the outcome. Platelets, albumin, CTP, and MELD scores were the independent contributors to mortality. Thus, as liver cirrhosis prognosticators, CTP and MELD scores can also both be used as predictive scores of the in-hospital outcomes of bleeding patients due to portal hypertension. Compared to the GB score, CTP and MELD scores are fairly efficient predictors in these patients

Evaluation of diuretic activity of Paspalidium flavidum in rats

This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Paspalidium flavidum in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibiteda significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. flavidum contain certain biologically active compounds that might be responsible for the diuretic activity

Comparative study to evaluate the effect of colloid coloading versus crystalloid coloading for prevention of spinal anaesthesia induced hypotension and effect on fetal Apgar score in patients undergoing elective lower segment caesarean section: a prospective observational study

Background: Spinal anesthesia for LSCS has a high incidence of maternal hypotension which can be severe and disastrous for the fetus and the mother. Coloading in these patients is a physiologically more appropriate method for preventing spinal anesthesia induced hypotension.Methods: 100 ASA I patients for elective LSCS were randomly divided into two equal groups to either receive 1000ml colloid (6% Hetastarch) or 1000ml crystalloids (Ringer lactate) as coload. NIBP, heart rate SPO2 and incidence of nausea and vomiting and use of ephedrine to treat any hypotension was recorded. Fetal outcome was measured using APGAR score at 0, 1 and 5 minutes.Results: The incidence of hypotension was lesser with colloid coload group (41.7%) as compared to the crystalloid coload group (58.3%) but the difference between the two groups was statistically insignificant. Similarly, no statistically significant difference was noted in the incidence of nausea and vomiting and Fetal APGAR score between the two groups.Conclusions: Both Colloid and Crystalloid coloading is effective in decreasing the incidence of spinal anesthesia induced hypotension during LSCS with lesser incidence of hypotension and nausea vomiting with colloid coloading